What is the GHS hazard classification for Diacetone alcohol?
Diacetone alcohol (CAS 123-42-2) is classified under EU CLP Annex VI as Eye Irrit. 2 with signal word Warning. Hazard statements: H319. Source: EU CLP Annex VI (ECHA).
Warning
GHS07
NOAEL Data
REACH Registered
Cosmetic Ingredient
Diacetone alcohol
Also known as: 4-Hydroxy-4-methyl-2-pentanone, 4-01-00-04023, BRN 1740440, Caswell No. 280, Diacetone (+13 more)
CAS 123-42-2
Diacetone alcohol (CAS 123-42-2) is a chemical substance with GHS signal word Warning; key hazard signal: H319. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
24 fields
Name
Diacetone alcohol
CAS Number
123-42-2
DTXSID
DTXSID6024917
Molecular Formula
C6H12O2
InChI Key
SWXVUIWOUIDPGS-UHFFFAOYSA-N
Monoisotopic Mass
116.08373
Synonyms
4-Hydroxy-4-methyl-2-pentanone4-01-00-04023BRN 1740440Caswell No. 280DiacetoneDiacetonyl alcoholEINECS 204-626-7EPA Pesticide Chemical Code 0339014-Hydroxy-4-methyl pentan-2-one4-Hydroxy-4-methylpentanone-2Pyranton4-Hydroxy-4-methyl-pentan-2-on
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Eye Irrit. 2 | H319 | GHS07 | Warning |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. Exposure far above the OEL could cause lowering of consciousness. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
5 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 50 ppm (240 mg/m³) | 50 | 240 | N |
| NIOSH | TWA | 50 ppm (240 mg/m³) | 50 | 240 | N |
| ACGIH | TWA | 50 ppm [1979] | 50 | - | N |
| CAL/OSHA | TWA | 50 ppm (240 mg/m³) | 50 | 240 | N |
| NIOSH | IDLH | 1800 ppm | 1800 | - | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
16 records
SolventDeodorizerFragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| artificial_saliva; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| artificial_saliva; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - shoes; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - shoes; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe | European Commission | Fl@vis |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =32.6 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| Q7WP157PTD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Q7WP157PTD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Q7WP157PTD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Q7WP157PTD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =2520 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =3002 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =4000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =85517 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 4-hydroxy-4-methylpentan-2-one | 204-626-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3182048
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Diacetone alcohol?
Diacetone alcohol has 10 NOAEL studies in the database. The lowest reported value is 32.6 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
What regulatory lists include Diacetone alcohol?
Diacetone alcohol appears on 7 regulatory/inventory lists including artificial_saliva; detected; emissions; Europe; Toys and children's products, artificial_saliva; detected; emissions; Europe; Other direct contact consumer goods, Cleaning products and household care - shoes; Europe, and 4 more. Source: EPA CPDat.
What are the occupational exposure limits for Diacetone alcohol?
Occupational exposure limits for Diacetone alcohol are set by OSHA, NIOSH, ACGIH. 5 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Diacetone alcohol used in cosmetics?
Yes, Diacetone alcohol is also indexed as a cosmetic ingredient under the name Diacetone Alcohol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Diacetone alcohol come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Diacetone alcohol used outside industrial chemicals?
Diacetone alcohol also appears in cosmetics, pharmaceutical, cannabis databases.