What is the NOAEL for 2,5-Dimethylpyrazine?
2,5-Dimethylpyrazine has 5 NOAEL studies in the database. The lowest reported value is V99Y0MUY1Q UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
2,5-Dimethylpyrazine
Also known as: 2,5-Dimethyl-1,4-diazine, 2,5-Dimethylparadiazine, 2,5-Dimethylpiazine, EINECS 204-618-3, FEMA No. 3272 (+6 more)
CAS 123-32-0
2,5-Dimethylpyrazine (CAS 123-32-0) is a chemical substance. Key regulatory status: 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
2,5-Dimethylpyrazine
CAS Number
123-32-0
DTXSID
DTXSID6047652
Molecular Formula
C6H8N2
InChI Key
LCZUOKDVTBMCMX-UHFFFAOYSA-N
Monoisotopic Mass
108.068748
Synonyms
2,5-Dimethyl-1,4-diazine2,5-Dimethylparadiazine2,5-DimethylpiazineEINECS 204-618-3FEMA No. 3272UNII-V99Y0MUY1Q2, 5-Dimethylpyrazine2,5-Dimethyl pyrazine2,5-Dimethyl-PyrazineFEMA 3272PYRAZINE,2,5-DIMETHYL
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| V99Y0MUY1Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| V99Y0MUY1Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| V99Y0MUY1Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| V99Y0MUY1Q | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1020 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
Showing 5 of 5 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL94709
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2,5-Dimethylpyrazine?
2,5-Dimethylpyrazine appears on 5 regulatory/inventory lists including Australia; Food and drug - smoking-related products, IFRA Transparency, Europe, and 2 more. Source: EPA CPDat.
Is 2,5-Dimethylpyrazine used in cosmetics?
Yes, 2,5-Dimethylpyrazine is also indexed as a cosmetic ingredient under the name 2,5-DIMETHYLPYRAZINE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,5-Dimethylpyrazine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 2,5-Dimethylpyrazine used outside industrial chemicals?
2,5-Dimethylpyrazine also appears in cosmetics, pharmaceutical, food safety, cannabis databases.