What is the NOAEL for 4-Methoxybenzaldehyde?
4-Methoxybenzaldehyde has 15 NOAEL studies in the database. The lowest reported value is 5.88 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
4-Methoxybenzaldehyde
Also known as: 4-Anisaldehyde, p-Anisaldehyde, Caswell No. 051E, EINECS 204-602-6, FEMA No. 2670 (+2 more)
CAS 123-11-5
4-Methoxybenzaldehyde (CAS 123-11-5) is a chemical substance. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Anisaldehyde (p-Methoxybenzaldehyde) →
SOURCE
noael studies public
NOAEL studies
15
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
4-Methoxybenzaldehyde
CAS Number
123-11-5
DTXSID
DTXSID2026997
Molecular Formula
C8H8O2
InChI Key
ZRSNZINYAWTAHE-UHFFFAOYSA-N
Monoisotopic Mass
136.052429
Synonyms
4-Anisaldehydep-AnisaldehydeCaswell No. 051EEINECS 204-602-6FEMA No. 2670Formylanisole, p-UNII-9PA5V6656V
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
PreservativeFragranceDeodorizerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| Europe; nondetect; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 15 of 15 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =5.88 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 9PA5V6656V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9PA5V6656V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9PA5V6656V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9PA5V6656V | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 6480 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =1510 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =500 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_EPA_TSCA_8e |
| =50 | mg/kg bw/day | LOEL | injection | Mouse | ToxValDB_ECOTOX |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =20 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =20 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 15 of 15 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Anisaldehyde | 204-602-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ANISALDEHYDE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
3
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 4-Methoxybenzaldehyde?
4-Methoxybenzaldehyde appears on 7 regulatory/inventory lists including Europe, inert_ingredient; non_food_use; Pesticides, detected; Europe; Personal care - sexual wellness, and 4 more. Source: EPA CPDat.
Is 4-Methoxybenzaldehyde used in cosmetics?
Yes, 4-Methoxybenzaldehyde is also indexed as a cosmetic ingredient under the name Anisaldehyde (p-Methoxybenzaldehyde). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4-Methoxybenzaldehyde come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 4-Methoxybenzaldehyde used outside industrial chemicals?
4-Methoxybenzaldehyde also appears in cosmetics, pharmaceutical, cannabis databases.