What is the NOAEL for 4-Ethylphenol?
4-Ethylphenol has 11 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.
NOAEL Data
REACH Registered
Cosmetic Ingredient
4-Ethylphenol
Also known as: 4-06-00-03020, BRN 1363317, EINECS 204-598-6, FEMA No. 3156, 1-Hydroxy-4-ethylbenzene (+5 more)
CAS 123-07-9
4-Ethylphenol (CAS 123-07-9) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
4-Ethylphenol is classified GHS Danger (H314, H318) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
6
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
4-Ethylphenol
CAS Number
123-07-9
DTXSID
DTXSID4021977
Molecular Formula
C8H10O
InChI Key
HXDOZKJGKXYMEW-UHFFFAOYSA-N
Monoisotopic Mass
122.073165
Synonyms
4-06-00-03020BRN 1363317EINECS 204-598-6FEMA No. 31561-Hydroxy-4-ethylbenzene4-HydroxyethylbenzeneHydroxyphenylethane, p-4-Hydroxyphenylethanepara-EthylphenolUNII-AGG7E6G0ZC
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
8 records
FragranceFlavouring and nutrientProcessing aids not otherwise specifiedSurface modifier
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 54.0425139317328 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 428000 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 44.6362455584907 | uM | ACC | - | - | NTP_ICE_endocrine |
| =8.167 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| AGG7E6G0ZC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| AGG7E6G0ZC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| AGG7E6G0ZC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.00352 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 300 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 342 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 4-ethylphenol | 204-598-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL108475
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 4-Ethylphenol?
4-Ethylphenol appears on 5 regulatory/inventory lists including detected; MN Chemical Screening; surface_water, Europe, IFRA Transparency, and 2 more. Source: EPA CPDat.
Is 4-Ethylphenol used in cosmetics?
Yes, 4-Ethylphenol is also indexed as a cosmetic ingredient under the name 4-Ethylphenol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4-Ethylphenol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 4-Ethylphenol have different safety status in cosmetics vs industrial chemicals?
4-Ethylphenol is classified GHS Danger (H314, H318) in the chemicals database but is allowed in EU cosmetics.
Is 4-Ethylphenol used outside industrial chemicals?
4-Ethylphenol also appears in cosmetics, pharmaceutical, cannabis databases.