What is the GHS hazard classification for Galaxolide?
Galaxolide (CAS 1222-05-5) is classified under EU CLP Annex VI as Aquatic Acute 1; Aquatic Chronic 1 with signal word Warning. Hazard statements: H400; H410. Source: EU CLP Annex VI (ECHA).
Warning
GHS09
NOAEL Data
REACH Registered
Cosmetic Ingredient
Galaxolide
Also known as: 1,3,4,6,7,8-hexahidro-4,6,6,7,8,8-hexametilindeno[5,6-c]pirano, 1,3,4,6,7,8-HEXAHYDRO-4,6,6,7,8,8- HEXAMETHYL CYCLOPENTA-γ-2-BENZOPYRAN, 1,3,4,6,7,8-HEXAHYDRO-4,6,6,7,8,8-HEXAMETHYL CYCLOPENTA-[g]-2-BENZOPYRAN, 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclo-penta[g]-2-benzo pyrane, 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran (+11 more)
CAS 1222-05-5
Galaxolide (CAS 1222-05-5) is a chemical substance with GHS signal word Warning; key hazard signal: H400; H410. Key regulatory status: REACH registered, 19 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, EPA TRI.
SOURCE
noael studies public
NOAEL studies
32
SOURCE
chemical inventory jurisdictions
Regulatory lists
19
SOURCE
eu clp annex vi
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
22 fields
Name
Galaxolide
CAS Number
1222-05-5
DTXSID
DTXSID8027373
Molecular Formula
C18H26O
InChI Key
ONKNPOPIGWHAQC-UHFFFAOYSA-N
Monoisotopic Mass
258.198365
Synonyms
1,3,4,6,7,8-hexahidro-4,6,6,7,8,8-hexametilindeno[5,6-c]pirano1,3,4,6,7,8-HEXAHYDRO-4,6,6,7,8,8- HEXAMETHYL CYCLOPENTA-γ-2-BENZOPYRAN1,3,4,6,7,8-HEXAHYDRO-4,6,6,7,8,8-HEXAMETHYL CYCLOPENTA-[g]-2-BENZOPYRAN1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclo-penta[g]-2-benzo pyrane1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylindeno[5,6-c]pyran1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylindeno[5,6-c]pyrane1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylindeno[5,6-c]pyranneCYCLOPENTA[G]-2-BENZOPYRAN,1,3,4,6,7,8-HEXAHYDRO- 4,6,6,7,8,8-HEXAMETHYL-EINECS 214-946-9Galoxolide1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta-gamma-2-benzopyran
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Aquatic Acute 1; Aquatic Chronic 1 | H400; H410 | GHS09 | Warning |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Fragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
19 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Chemicals Agency | European Chemicals Agency (ECHA) |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Other direct contact consumer goods | Environmental Health Perspectives | Published Articles |
| detected; MN Chemical Screening; surface_water | USGS | State of Minnesota |
| detected; MN Chemical Screening; surface_water | National Parks Service | State of Minnesota |
| detected; MN Chemical Screening; surface_water | NPS & EPA | State of Minnesota |
| detected; wastewater | USGS | United States Geological Survey (USGS) |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| Cleaning products and household care - air freshener; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; MN Chemical Screening; wastewater | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | USGS | State of Minnesota |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; ground_water; MN Chemical Screening | Minnesota Pollution Control Agency | State of Minnesota |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 32 of 32 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 50 | mg/kg | - | - | - | UnifiedCodex:SCCNFP:beta.noael_studies |
| =13.5 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 14170060AT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 14170060AT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 14170060AT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 14170060AT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 9720 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >4640 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =34 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =38 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =150 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_EPA_TSCA_8e |
| =300 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =300 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_HPVIS |
| =500 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_EPA_TSCA_8e |
| =20 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =30 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =50 | mg/kg | NOAEL | dermal | human | SCCNFP_vision_codex |
| =50 | mg/kg | NOAEL | dermal | human | SCCNFP_vision_codex |
| =50 | mg/kg | NOAEL | dermal | human | SCCNFP_vision_codex |
| =50 | mg/kg | NOAEL | dermal | human | SCCNFP_vision_codex |
| >=100 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| <121 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =150 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =300 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| >=1650 | ppm | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| =50 | mg/kg | dermal absorption | dermal | human | UnifiedCodex:SCCNFP:beta.noael_studies |
| =50 | mg/kg | dermal absorption | dermal | human | UnifiedCodex:SCCNFP:beta.noael_studies |
| =50 | mg/kg | dermal absorption | dermal | human | UnifiedCodex:SCCNFP:beta.noael_studies |
Showing 32 of 32 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylindeno[5,6-c]pyran | 214-946-9 | ECHA overview → |
EPA Toxic Release Inventory (TRI)
TRI hazard and reporting flags for the matched chemical.
SOURCE
EPA Toxics Release Inventory (TRI) chemical list
1 records
| Chemical | Category | Flags |
|---|---|---|
| 1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran (HHCB) | - | - |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
Labeling required above 10 ppm leave-on / 100 ppm rinse-off
Category
fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1883305
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What is the NOAEL for Galaxolide?
Galaxolide has 32 NOAEL studies in the database. The lowest reported value is 13.5 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
What regulatory lists include Galaxolide?
Galaxolide appears on 10 regulatory/inventory lists including IFRA Transparency, Europe, inert_ingredient; non_food_use; Pesticides, and 7 more. Source: EPA CPDat.
Is Galaxolide used in cosmetics?
Yes, Galaxolide is also indexed as a cosmetic ingredient under the name Galaxolide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Galaxolide come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Galaxolide used outside industrial chemicals?
Galaxolide also appears in cosmetics, pharmaceutical databases.