What is the NOAEL for 4-(4-Hydroxy-3-methoxyphenyl)-2-butanone?
4-(4-Hydroxy-3-methoxyphenyl)-2-butanone has 11 NOAEL studies in the database. The lowest reported value is 4MMW850892 UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
4-(4-Hydroxy-3-methoxyphenyl)-2-butanone
Also known as: Zingerone, 4-08-00-01866, BRN 2051099, EINECS 204-548-3, FEMA No. 3124 (+15 more)
CAS 122-48-5
4-(4-Hydroxy-3-methoxyphenyl)-2-butanone (CAS 122-48-5) is a chemical substance. Key regulatory status: 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
6
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
4-(4-Hydroxy-3-methoxyphenyl)-2-butanone
CAS Number
122-48-5
DTXSID
DTXSID8047420
Molecular Formula
C11H14O3
InChI Key
OJYLAHXKWMRDGS-UHFFFAOYSA-N
Monoisotopic Mass
194.094294
Synonyms
Zingerone4-08-00-01866BRN 2051099EINECS 204-548-3FEMA No. 31243-Methoxy-4-hydroxy-benzylacetoneNSC 15335(O)-ParadolVanillyl acetoneUNII-4MMW850892(0)-Paradol(4-Hydroxy-3-methoxyphenyl)ethyl methyl ketone
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
8 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| consumer_product | P&G | Proctor & Gamble |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe | European Commission | Fl@vis |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 4MMW850892 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4MMW850892 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4MMW850892 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4MMW850892 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 5400 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =2580 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =128 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =128 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =128 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 11 of 11 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ZINGERONE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 4-(4-Hydroxy-3-methoxyphenyl)-2-butanone?
4-(4-Hydroxy-3-methoxyphenyl)-2-butanone appears on 6 regulatory/inventory lists including consumer_product, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 3 more. Source: EPA CPDat.
Is 4-(4-Hydroxy-3-methoxyphenyl)-2-butanone used in cosmetics?
Yes, 4-(4-Hydroxy-3-methoxyphenyl)-2-butanone is also indexed as a cosmetic ingredient under the name ZINGERONE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4-(4-Hydroxy-3-methoxyphenyl)-2-butanone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 4-(4-Hydroxy-3-methoxyphenyl)-2-butanone used outside industrial chemicals?
4-(4-Hydroxy-3-methoxyphenyl)-2-butanone also appears in cosmetics, pharmaceutical, food safety, cannabis databases.