What is the GHS hazard classification for Triisopropanolamine?
Triisopropanolamine (CAS 122-20-3) is classified under EU CLP Annex VI as Eye Irrit. 2 with signal word Warning. Hazard statements: H319. Source: EU CLP Annex VI (ECHA).
Warning
GHS07
NOAEL Data
REACH Registered
Cosmetic Ingredient
Triisopropanolamine
Also known as: Tris(2-hydroxypropyl)amine, Tri-iso-propanolamine, 4-04-00-01680, BRN 1071570, Caswell No. 891 (+4 more)
CAS 122-20-3
Triisopropanolamine (CAS 122-20-3) is a chemical substance with GHS signal word Warning; key hazard signal: H319. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
Triisopropanolamine
CAS Number
122-20-3
DTXSID
DTXSID5021415
Molecular Formula
C9H21NO3
InChI Key
SLINHMUFWFWBMU-UHFFFAOYSA-N
Monoisotopic Mass
191.152144
Synonyms
Tris(2-hydroxypropyl)amineTri-iso-propanolamine4-04-00-01680BRN 1071570Caswell No. 891EINECS 204-528-4EPA Pesticide Chemical Code 0042093,3',3"-Nitrilotri(2-propanol)UNII-W9EN9DLM98
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Eye Irrit. 2 | H319 | GHS07 | Warning |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | Causes serious eye irritation Causes skin irritation May cause respiratory irritation |
| Short-term Effects | The substance is severely irritating to the eyes. The substance is irritating to the skin and respiratory tract. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
pH regulating agentCorrosion inhibitorEmulsifier
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =86 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| W9EN9DLM98 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| W9EN9DLM98 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| W9EN9DLM98 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| W9EN9DLM98 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1000 | mg/kg bw/day | LEL | oral | Rabbit | ToxValDB_EPA_TSCA_8e |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 288 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| =400 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HPVIS |
| >=1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HPVIS |
| >1216 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HPVIS |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1,1',1''-nitrilotripropan-2-ol | 204-528-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.5%
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1877948
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What is the NOAEL for Triisopropanolamine?
Triisopropanolamine has 11 NOAEL studies in the database. The lowest reported value is 86 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
What regulatory lists include Triisopropanolamine?
Triisopropanolamine appears on 5 regulatory/inventory lists including Europe; plastic_additive, inert_ingredient; non_food_use; Pesticides, CEDI, and 2 more. Source: EPA CPDat.
Is Triisopropanolamine used in cosmetics?
Yes, Triisopropanolamine is also indexed as a cosmetic ingredient under the name Triisopropanolamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Triisopropanolamine come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Triisopropanolamine used outside industrial chemicals?
Triisopropanolamine also appears in cosmetics, pharmaceutical databases.