What is the NOAEL for Attapulgite?
Attapulgite has 15 NOAEL studies in the database. The lowest reported value is cancer listing type. Source: California Proposition 65.
NOAEL Data
IARC Group 2B
Prop 65
Cosmetic Ingredient
Attapulgite
Also known as: Activated attapulgite, Attapulgite, activated, Attapulgus clay, Clay, attapulgite, Palygorscite (+7 more)
CAS 12174-11-7
Attapulgite (CAS 12174-11-7) is a chemical substance; key hazard signal: IARC Group 2B. Key regulatory status: California Proposition 65, 11 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, CA Prop 65, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
15
SOURCE
chemical inventory jurisdictions
Regulatory lists
11
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
Attapulgite
CAS Number
12174-11-7
DTXSID
DTXSID6050469
Synonyms
Activated attapulgiteAttapulgite, activatedAttapulgus clayClay, attapulgitePalygorscitePharmasorb-colloidalPalygorskitActapulgiteRheabanUNII-U6V729APAMToxi-sorb calf bolusToxi-sorb bolus
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
2 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 2B | Possibly carcinogenic | 1996 | 68 |
| Group 3 | Not classifiable | 1996 | 68 |
California Proposition 65
California OEHHA listing status and toxicity category.
SOURCE
California OEHHA Proposition 65 List
1 records
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Long-term Effects | Repeated or prolonged inhalation of fibres may cause effects on the lungs. This may result in fibrosis. This substance is possibly carcinogenic to humans. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
38 records
AbrasiveAbsorbentViscosity modifierOpaciferFillerThickening agentFlow promoterProcessing aids not otherwise specified
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
11 records
| List | Keyword | Source |
|---|---|---|
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 15 of 15 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| U6V729APAM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U6V729APAM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U6V729APAM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U6V729APAM | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2 | unitless | IARC group | - | - | NTP_ICE_cancer |
Showing 15 of 15 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
mineral
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
attapulgite
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Frequently Asked Questions
What regulatory lists include Attapulgite?
Attapulgite appears on 8 regulatory/inventory lists including Canada; Personal care; Substances in PCP - Canada (4/2014), active_ingredient; Pesticides, inert_ingredient; Pesticides, and 5 more. Source: EPA CPDat.
Is Attapulgite a carcinogen according to IARC?
Attapulgite is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 1996). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Attapulgite on the California Proposition 65 list?
Yes, Attapulgite is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Is Attapulgite used in cosmetics?
Yes, Attapulgite is also indexed as a cosmetic ingredient under the name Attapulgite. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Attapulgite come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, California Proposition 65, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Attapulgite used outside industrial chemicals?
Attapulgite also appears in cosmetics, pharmaceutical, food safety databases.