Also known as: (NH4)Cl, Ammonium chloride ((NH4)Cl), A649-3, Amoklor, Darvan 20 (+15 more)
CAS 12125-02-9
Ammonium chloride (CAS 12125-02-9) is a chemical substance with GHS signal word Warning; key hazard signal: H302; H319. Key regulatory status: REACH registered, 18 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 *; Eye Irrit. 2 | H302; H319 | GHS07 | Warning |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of dust or fume and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| NIOSH | TWA | 10 mg/m³ | - | 10 | N |
| NIOSH | STEL | 20 mg/m³ | - | 20 | N |
| ACGIH | TWA | 10 mg/m³ [1970] | - | 10 | N |
| ACGIH | STEL | 20 mg/m³ [1970] | - | 20 | N |
| CAL/OSHA | TWA | 10 mg/m³ | - | 10 | N |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| fracking; water | NY Department of Conservation | CPCat |
| fracking | FracFocus | FracFocus |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =33.5 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =43.97 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 01Q9PC255D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 01Q9PC255D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 01Q9PC255D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 01Q9PC255D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =10000 | mg/kg bw/day | LEL | oral | Sheep | ToxValDB_EFSA |
| =15000 | mg/kg bw/day | LEL | oral | Sheep | ToxValDB_EFSA |
| 200 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| 253 | mg/kg bw/day | NOAEL | oral | cattle | COSMOS_DB |
| 500 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS_DB |
| 700 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 750 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1000 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS_DB |
| 1050 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 2000 | mg/kg bw/day | NOAEL | oral | cat | COSMOS_DB |
| =684 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 18 of 18 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Ammonium chloride | 235-186-4 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS food additive, ADI, and GRAS records where available.
E510 — ADI: NOT LIMITED mg/kg bw
View full food safety profile →Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Ammonium chloride (CAS 12125-02-9) is classified under EU CLP Annex VI as Acute Tox. 4 *; Eye Irrit. 2 with signal word Warning. Hazard statements: H302; H319. Source: EU CLP Annex VI (ECHA).
Ammonium chloride has 18 NOAEL studies in the database. The lowest reported value is 33.5 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
Ammonium chloride appears on 9 regulatory/inventory lists including inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, active_ingredient; Pesticides, and 6 more. Source: EPA CPDat.
Occupational exposure limits for Ammonium chloride are set by NIOSH, ACGIH, CAL/OSHA. 5 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Ammonium chloride is also indexed as a cosmetic ingredient under the name Ammonium Chloride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Ammonium chloride also appears in cosmetics, pharmaceutical, food safety, cannabis databases.