Also known as: Ethanamine, N,N-diethyl-, EINECS 204-469-4, UNII-VOU728O6AY, (C2H5)3N, N,N,N-triethylamine (+3 more)
CAS 121-44-8
Triethylamine (CAS 121-44-8) is a chemical substance with GHS signal word Danger; key hazard signal: H225; H331; H311; H301; H314; H318. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA, EPA TRI.
Triethylamine is classified GHS Danger (H225, H331, H311, H301, H314, H318) in the chemicals database but is allowed in EU cosmetics.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 2; Acute Tox. 3; Acute Tox. 3; Acute Tox. 3; Skin Corr. 1A; Eye Dam. 1 | H225; H331; H311; H301; H314; H318 | GHS02; GHS06; GHS05 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema. See Notes. The effects may be delayed. Medical observation is indicated. The substance may cause effects on the central nervous system. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation, through the skin and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 25 ppm (100 mg/m³) | 25 | 100 | N |
| ACGIH | TWA | 0.5 ppm [2014] | 0.5 | - | Y |
| ACGIH | STEL | 1 ppm [2014] | 1 | - | Y |
| CAL/OSHA | CEILING | 1 ppm (4.1 mg/m³) | 1 | 4.1 | Y |
| NIOSH | IDLH | 200 ppm | 200 | - | - |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Arts and crafts/Office supplies - fabric treatment and dye; detected | Danish Environmental Protection Agency | Danish EPA |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Arts and crafts/Office supplies - fabric treatment and dye; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =8.4 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| VOU728O6AY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| VOU728O6AY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| VOU728O6AY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| VOU728O6AY | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 10.9 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 14.441 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 14.4601 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =460 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =730 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1030 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =3 | mg/m3 | LEL | inhalation | Mouse | ToxValDB_ECHA_IUCLID |
| =50 | mg/m3 | LEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =103.47 | mg/m3 | LEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =210 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =500 | mg/m3 | LEL | inhalation | Mouse | ToxValDB_ECHA_IUCLID |
| =1000 | mg/m3 | LEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =1034.7 | mg/m3 | LEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =4223 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =49665.5 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| =198.662 | mg/m3 | LOAEC | inhalation | Rabbit | ToxValDB_ECHA_IUCLID |
| =210 | mg/m3 | LOAEC | inhalation | Rabbit | ToxValDB_ECHA_IUCLID |
| =6.20819 | mg/m3 | LOAEL | inhalation | Human | ToxValDB_EU_SCOEL |
| =103.3 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =1020 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =0.1 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =2.89716 | mg/m3 | NOAEL | inhalation | Human | ToxValDB_EU_SCOEL |
| =10 | mg/m3 | NOAEL | inhalation | Human | ToxValDB_Cal_OEHHA_REL_derivations |
| =103.47 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_Cal_OEHHA_REL_derivations |
| =1022.2 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_IRIS |
| =1033 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =182.5 | mg/m3 | NOAEL (ADJ) | inhalation | Rat | ToxValDB_IRIS |
| =19.5 | mg/m3 | NOAEL (HEC) | inhalation | Rat | ToxValDB_IRIS |
| =19.5 | mg/m^3 | NOAEL (HEC) | inhalation | - | EPA_IRIS_iris_rfc_systems.csv |
| =0.007 | mg/m3 | RfC | inhalation | Human | ToxValDB_IRIS |
| =0.007 | mg/m^3 | RfC | inhalation | - | EPA_IRIS_iris_rfc_systems.csv |
Showing 36 of 36 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Triethylamine | 204-469-4 | ECHA overview → |
TRI hazard and reporting flags for the matched chemical.
| Chemical | Category | Flags |
|---|---|---|
| Triethylamine | - | - |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Triethylamine (CAS 121-44-8) is classified under EU CLP Annex VI as Flam. Liq. 2; Acute Tox. 3; Acute Tox. 3; Acute Tox. 3; Skin Corr. 1A; Eye Dam. 1 with signal word Danger. Hazard statements: H225; H331; H311; H301; H314; H318. Source: EU CLP Annex VI (ECHA).
Triethylamine has 36 NOAEL studies in the database. The lowest reported value is 8.4 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
Triethylamine appears on 7 regulatory/inventory lists including Arts and crafts/Office supplies - fabric treatment and dye; detected, drinking_water; Europe; manufacturing; plastic_additive, Canada; consumer_product; Substances in Products - Canada (4/2014), and 4 more. Source: EPA CPDat.
Occupational exposure limits for Triethylamine are set by OSHA, ACGIH, CAL/OSHA. 5 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Triethylamine is also indexed as a cosmetic ingredient under the name Triethylamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Triethylamine is classified GHS Danger (H225, H331, H311, H301, H314, H318) in the chemicals database but is allowed in EU cosmetics.
Triethylamine also appears in cosmetics, pharmaceutical, cannabis databases.