What is the NOAEL for Vanillic acid?
Vanillic acid has 4 NOAEL studies in the database. The lowest reported value is GM8Q3JM2Y8 UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Vanillic acid
Also known as: BRN 2208364, EINECS 204-466-8, VA (VAN), UNII-GM8Q3JM2Y8, 3-Methoxy-4-hydroxybenzoate (+11 more)
CAS 121-34-6
Vanillic acid (CAS 121-34-6) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
4
SOURCE
Chemical inventory jurisdictions
Regulatory lists
4
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
22 fields
Name
Vanillic acid
CAS Number
121-34-6
DTXSID
DTXSID6059522
Molecular Formula
C8H8O4
InChI Key
WKOLLVMJNQIZCI-UHFFFAOYSA-N
Monoisotopic Mass
168.042259
Synonyms
BRN 2208364EINECS 204-466-8VA (VAN)UNII-GM8Q3JM2Y83-Methoxy-4-hydroxybenzoate4-Hydroxy-3-methoxy-Benzoate4-Hydroxy-m-Anisate4-Hydroxy-m-Anisic acid4-hydroxy-3-methoxy-benzoic acidBenzoic acid, 4-hydroxy-3-methoxy-Protocatechuic acid 3-methyl esterProtocatechuic acid, 3-methyl ester
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
4 records
Flavouring and nutrientFragranceNo specific technical function
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| GM8Q3JM2Y8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GM8Q3JM2Y8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GM8Q3JM2Y8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GM8Q3JM2Y8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Vanillic acid | 204-466-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
VANILLIC ACID
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
5
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Vanillic acid?
Vanillic acid appears on 4 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is Vanillic acid used in cosmetics?
Yes, Vanillic acid is also indexed as a cosmetic ingredient under the name Vanillic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Vanillic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Vanillic acid used outside industrial chemicals?
Vanillic acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.