What is the NOAEL for 4-Hydroxy-3-methoxybenzaldehyde?
4-Hydroxy-3-methoxybenzaldehyde has 62 NOAEL studies in the database. The lowest reported value is -6.6 % via Dermal. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
4-Hydroxy-3-methoxybenzaldehyde
Also known as: Vanillin, 4-08-00-01763, BRN 0472792, EINECS 204-465-2, FEMA No. 3107 (+15 more)
CAS 121-33-5
4-Hydroxy-3-methoxybenzaldehyde (CAS 121-33-5) is a chemical substance. Key regulatory status: REACH registered, 29 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
62
SOURCE
chemical inventory jurisdictions
Regulatory lists
29
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
4-Hydroxy-3-methoxybenzaldehyde
CAS Number
121-33-5
DTXSID
DTXSID0021969
Molecular Formula
C8H8O3
InChI Key
MWOOGOJBHIARFG-UHFFFAOYSA-N
Monoisotopic Mass
152.047344
Synonyms
Vanillin4-08-00-01763BRN 0472792EINECS 204-465-2FEMA No. 3107Methylprotocatechuic aldehydeProtocatechualdehyde, methyl-Protocatechualdehyde 3-methyl etherUNII-CHI530446X3-Methoxy-4-hydroxybenzaldehyde (vanillin)4-Hydroxy-3-methoxy-Benzaldehyde-5-chlorovanillin4-Hydroxy-3-methoxybenzaldehyde (ACD/Name 4.0)
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | May be harmful if swallowed Harmful to aquatic life |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceDeodorizerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
29 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| consumer_product | P&G | Proctor & Gamble |
| Canada; pharmaceutical | DrugBank | DrugBank |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| inert_ingredient; Pesticides | EPA | CPCat |
| artificial_saliva; detected; emissions; Europe; Furniture and Furnishings | Danish Environmental Protection Agency | Danish EPA |
| artificial_saliva; detected; emissions; Europe; Other indirect contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - air freshener; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| Cons electronics mech appliances and machinery; detected; Europe | Danish EPA | Danish EPA |
| Cons electronics mech appliances and machinery; detected; Europe | Danish EPA | Danish EPA |
| Cons electronics mech appliances and machinery; detected; Europe | Danish EPA | Danish EPA |
| detected; Toys and children's products | Springer Berlin Heidelberg | Published Articles |
| detected; Toys and children's products | Springer | Published Articles |
| detected; Toys and children's products | Scientific Reports | Published Articles |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| consumer_product | P&G | Proctor & Gamble |
| artificial_saliva; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| artificial_sweat; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 62 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| <=10 | mg/kg | ADI | oral | Human | ToxValDB_WHO_JECFA_ADI |
| =10 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =10 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| 49.9 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 104.999 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 301.17 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| >200 | ug/mL | CV70 | Dermal | - | NTP_ICE_skin_sensitization |
| 394.7 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 569 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 650 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 670 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 673 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 791.5 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 1364.7 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 234 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| -1.3 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 3.2 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| -6.6 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 19.8 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 1.6 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 9.25 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 83 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| >2000 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| CHI530446X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| CHI530446X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| CHI530446X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| CHI530446X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.322 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| >1650 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| >2000 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 1.4 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.478 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 2.29 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1241 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 3240 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =1580 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =2800 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =3300 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =3830 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =3925 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| <3978 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| >=78 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 100 | mg/kg bw/day | NOAEL | oral | dog | COSMOS_DB |
| =250 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =400 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =400 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =400 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
Showing 50 of 62 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Vanillin | 204-465-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
Labelling threshold: 10 ppm (leave-on) / 100 ppm (rinse-off) per EU Regulation 2023/1545. No concentration restriction in cosmetics.
Category
fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
VANILLIN
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
8
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: 0-10 mg/kg bw (1967) mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 4-Hydroxy-3-methoxybenzaldehyde?
4-Hydroxy-3-methoxybenzaldehyde appears on 19 regulatory/inventory lists including inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, consumer_product, and 16 more. Source: EPA CPDat.
Is 4-Hydroxy-3-methoxybenzaldehyde used in cosmetics?
Yes, 4-Hydroxy-3-methoxybenzaldehyde is also indexed as a cosmetic ingredient under the name Vanillin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4-Hydroxy-3-methoxybenzaldehyde come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 4-Hydroxy-3-methoxybenzaldehyde used outside industrial chemicals?
4-Hydroxy-3-methoxybenzaldehyde also appears in cosmetics, pharmaceutical, food safety, cannabis databases.