Also known as: Benzoic acid, phenylmethyl ester, 4-09-00-00307, Benzyl alcohol benzoic ester, BRN 2049280, Caswell No. 082 (+12 more)
CAS 120-51-4
Benzyl benzoate (CAS 120-51-4) is a chemical substance with GHS signal word Warning; key hazard signal: H302; H411. Key regulatory status: REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 *; Aquatic Chronic 2 | H302; H411 | GHS07; GHS09 | Warning |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. |
| Long-term Effects | Repeated or prolonged contact with skin may cause dermatitis. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - nails - nail polish | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Cleaning products and household care - air freshener; detected; Europe; Vehicle - car interior - auto air freshener | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - body hygiene - hand soap | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - body hygiene - body wash | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - hair styling and care - shampoo | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; detected; Europe; Personal care - body hygiene - body wash; Personal care - body hygiene - hand soap; Personal care - fragrance; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| children; detected; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - make-up and related | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - make-up and related | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - general household cleaning; Cleaning products and household care - laundry and fabric treatment - fabric softener; detected; Europe; Other direct contact consumer goods; Vehicle - car surface treatment - body cleaner | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| >200 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| >1485.736 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 297 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 297.2 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| =14.1 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 0.2 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 3 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 1.6 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 72.49 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 17 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 142.5 | uM | EC3 | Dermal | - | NTP_ICE_skin_sensitization |
| N863NB338G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N863NB338G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N863NB338G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N863NB338G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 767.19 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 5.75 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 19440 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =1700 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1900 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =2080 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =800 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =781 | mg/kg bw/day | NOAEL | dermal | Rat | ToxValDB_ECHA_IUCLID |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| 89.4 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 93.27 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 101.3 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 109.8 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 110.03 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 110.4 | % | Viability (18 hours) | Dermal | - | NTP_ICE_skin_irritation |
| 74.5 | % | Viability (42 hours) | Dermal | - | NTP_ICE_skin_irritation |
Showing 34 of 34 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Benzyl benzoate | 204-402-9 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Benzyl benzoate (CAS 120-51-4) is classified under EU CLP Annex VI as Acute Tox. 4 *; Aquatic Chronic 2 with signal word Warning. Hazard statements: H302; H411. Source: EU CLP Annex VI (ECHA).
Benzyl benzoate has 34 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.
Benzyl benzoate appears on 33 regulatory/inventory lists including Europe, detected; Europe; Personal care - nails - nail polish, active_ingredient; Pesticides, and 30 more. Source: EPA CPDat.
Yes, Benzyl benzoate is also indexed as a cosmetic ingredient under the name Benzyl Benzoate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Benzyl benzoate also appears in cosmetics, pharmaceutical, cannabis databases.