Danger GHS08GHS07GHS05GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

Clorophene

Also known as: ochlorophenol, 2-Benzyl-4-chlorophenol, Phenol, 4-chloro-2-(phenylmethyl)-, o-Cresol, 4-chloro-α-phenyl-, 4-06-00-04636 (+15 more)

CAS 120-32-1

Clorophene (CAS 120-32-1) is a chemical substance with GHS signal word Danger; key hazard signal: H351; H361f; H332; H373 (kidney); H315; H318; H317; H400; H410. Key regulatory status: REACH registered, 40 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Chlorophene →

SOURCE noael studies public
NOAEL studies
75
SOURCE chemical inventory jurisdictions
Regulatory lists
40
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields
Name
Clorophene
CAS Number
120-32-1
DTXSID
DTXSID5020154
Molecular Formula
C13H11ClO
InChI Key
NCKMMSIFQUPKCK-UHFFFAOYSA-N
Monoisotopic Mass
218.049843
Synonyms
ochlorophenol2-Benzyl-4-chlorophenolPhenol, 4-chloro-2-(phenylmethyl)-o-Cresol, 4-chloro-α-phenyl-4-06-00-04636Benzylchlorophenolo-Benzyl-p-chlorophenolBRN 1959194Caswell No. 0834-Chloro-alpha-phenyl-o-cresol4-Chloro-alpha-phenyl-ortho-cresolEINECS 204-385-8

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Carc. 2; Repr. 2; Acute Tox. 4; STOT RE 2; Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1H351; H361f; H332; H373 (kidney); H315; H318; H317; H400; H410GHS08; GHS07; GHS05; GHS09Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 7 records
BiocidePreservative

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 40 records
ListKeywordSource
inert_ingredient; non_food_use; PesticidesEPACPCat
active_ingredient; Europe; PesticidesEuropean CommissionCPCat
pharmaceuticalUS International Trade CommissionCPCat
banned; Europe; Personal careEuropean CommissionCosIng
banned; Europe; Personal careEuropean CommissionCosIng
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesCalifornia Department of Pesticide RegulationState of California
CEDIFDAUnited States Food and Drug Administration (FDA)
Indirect additives food contact (10/2018)FDAUnited States Food and Drug Administration (FDA)
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 75 studies
ValueUnitEndpointRouteSpeciesSource
13.891013324137uMAC50--NTP_ICE_endocrine
19.60639693uMAC50--NTP_ICE_endocrine
8.99756895548529uMACC--NTP_ICE_endocrine
18.20114586uMACC--NTP_ICE_endocrine
4.53uL/min/10^6 cellsClint-HumanNTP_ICE_adme_parameters
=3UnitlessEPA classificationoralRat (Male/Female)NTP_ICE_acute_oral
4unitlessEPA classificationDermalRatNTP_ICE_acute_dermal
7560BB0BO3UNIIFDA UNII substance identifier--openFDA substances
7560BB0BO3UNIIFDA UNII substance identifier--openFDA substances
7560BB0BO3UNIIFDA UNII substance identifier--openFDA substances
7560BB0BO3UNIIFDA UNII substance identifier--openFDA substances
0.00000325fractionFu-HumanNTP_ICE_adme_parameters
1unitlessGHS ClassificationOcularRabbitNTP_ICE_eye_irritation
=4UnitlessGHS classificationoralRat (Male/Female)NTP_ICE_acute_oral
5unitlessGHS classificationDermalRatNTP_ICE_acute_dermal
=5UnitlessGHS classificationoralRat (Male)NTP_ICE_acute_oral
=1700mg/kg bwLD50oralRatNTP_ICE_acute_oral
>5000mg/kgLD50DermalRatNTP_ICE_acute_dermal
>5000mg/kg bwLD50oralRat (Male)NTP_ICE_acute_oral
=5mg/kg bw/dayLELdermalRabbitToxValDB_ToxRefDB
=5mg/kg bw/dayLELdermalrabbit (new zealand white; New Zealand White)ToxRefDB_ToxRefDB_v3_pod.csv
=30mg/kg bw/dayLELoralrat (fischer; Fischer 344)ToxRefDB_ToxRefDB_v3_pod.csv
=60mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=60mg/kg bw/dayLELoralrat (fischer; Fischer 344)ToxRefDB_ToxRefDB_v3_pod.csv
=62.5mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=62.5mg/kg bw/dayLELoralrat (fischer; Fischer 344)ToxRefDB_ToxRefDB_v3_pod.csv
=75mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=75mg/kg bw/dayLELoralrat (wistar; Wistar)ToxRefDB_ToxRefDB_v3_pod.csv
=100mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=100mg/kg bw/dayLELoralrat (sprague dawley; Sprague Dawley (CD))ToxRefDB_ToxRefDB_v3_pod.csv
=120mg/kg bw/dayLELoralMouseToxValDB_ToxRefDB
=120mg/kg bw/dayLELoralmouse (b6c3f1; B6C3F1)ToxRefDB_ToxRefDB_v3_pod.csv
=125mg/kg bw/dayLELoralMouseToxValDB_ToxRefDB
=125mg/kg bw/dayLELoralmouse (b6c3f1; B6C3F1)ToxRefDB_ToxRefDB_v3_pod.csv
=375mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=375mg/kg bw/dayLELoralrat (wistar; Wistar)ToxRefDB_ToxRefDB_v3_pod.csv
=500mg/kg bw/dayLELoralMouseToxValDB_ToxRefDB
=500mg/kg bw/dayLELoralmouse (b6c3f1; B6C3F1)ToxRefDB_ToxRefDB_v3_pod.csv
>900mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
>900mg/kg bw/dayLELoralrat (sprague dawley; Sprague Dawley (CD))ToxRefDB_ToxRefDB_v3_pod.csv
=240mg/kg bw/dayLOAELoralRatToxValDB_ToxRefDB
=240mg/kg bw/dayLOAELoralrat (fischer; Fischer 344)ToxRefDB_ToxRefDB_v3_pod.csv
=480mg/kg bw/dayLOAELoralRatToxValDB_ToxRefDB
=480mg/kg bw/dayLOAELoralrat (fischer; Fischer 344)ToxRefDB_ToxRefDB_v3_pod.csv
=1000mg/kg bw/dayLOAELoralRatToxValDB_ToxRefDB
=1000mg/kg bw/dayLOAELoralrat (fischer; Fischer 344)ToxRefDB_ToxRefDB_v3_pod.csv
75mg/kg bw/dayLOELOralRatNTP_ICE_dart
375mg/kg bw/dayLOELOralRatNTP_ICE_dart
-unitlessModel Score--NTP_ICE_endocrine
0.018unitlessModel Score--NTP_ICE_endocrine

Showing 50 of 75 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredClorofene204-385-8ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
0.2%
Category
Preservative
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CLOROPHENE
ChEMBL Phase
2
Adverse Events
0
Bioactivity
3
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for Clorophene?

Clorophene (CAS 120-32-1) is classified under EU CLP Annex VI as Carc. 2; Repr. 2; Acute Tox. 4; STOT RE 2; Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H351; H361f; H332; H373 (kidney); H315; H318; H317; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Clorophene?

Clorophene has 75 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.

What regulatory lists include Clorophene?

Clorophene appears on 7 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, active_ingredient; Europe; Pesticides, pharmaceutical, and 4 more. Source: EPA CPDat.

Is Clorophene used in cosmetics?

Yes, Clorophene is also indexed as a cosmetic ingredient under the name Chlorophene. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Clorophene come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Clorophene have different safety status in cosmetics vs industrial chemicals?

Clorophene is classified GHS Danger (H351, H361f, H332, H373, H315, H318, H317, H400) in the chemicals database but is allowed in EU cosmetics at max 0.2%.

Is Clorophene used outside industrial chemicals?

Clorophene also appears in cosmetics, pharmaceutical databases.