NOAEL Data REACH Registered Cosmetic Ingredient

1-Benzyloxy-2-methoxy-4-(1-propenyl)benzene

Also known as: Benzyl alcohol, ether with isoeugenol, Benzyl isoeugenol, Benzyl isoeugenol ether, Benzyl 2-methoxy-4-propenylphenyl ether, 1-Benzyloxy-2-methoxy-4-propenylbenzene (+9 more)

CAS 120-11-6

1-Benzyloxy-2-methoxy-4-(1-propenyl)benzene (CAS 120-11-6) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Benzyl Isoeugenol →

Cross-Vertical Regulatory Divergence

1-Benzyloxy-2-methoxy-4-(1-propenyl)benzene is prohibited in EU cosmetics but has active industrial GHS classifications.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 20 fields

Name

1-Benzyloxy-2-methoxy-4-(1-propenyl)benzene

CAS Number

120-11-6

DTXSID

DTXSID0051605

Molecular Formula

C17H18O2

InChI Key

YKSSSKBJDZDZTD-CLTKARDFSA-N

Monoisotopic Mass

254.13068

Synonyms

Benzyl alcohol, ether with isoeugenolBenzyl isoeugenolBenzyl isoeugenol etherBenzyl 2-methoxy-4-propenylphenyl ether1-Benzyloxy-2-methoxy-4-propenylbenzeneEINECS 204-370-6FEMA No. 3698Isoeugenol, benzyl etherIsoeugenyl benzyl ether2-Methoxy-1-(phenylmethoxy)-4-(1-propenyl)benzene2-Methoxy-4-propenylphenyl benzyl etherNSC 46157

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 5 records

FragranceFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 4 records

List	Keyword	Source
Europe	European Commission	Fl@vis
IFRA Transparency	IFRA	IFRA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
consumer_product	P&G	Proctor & Gamble

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 13 of 13 studies

Value	Unit	Endpoint	Route	Species	Source
78Q46SZU33	UNII	FDA UNII substance identifier	-	-	openFDA substances
78Q46SZU33	UNII	FDA UNII substance identifier	-	-	openFDA substances
78Q46SZU33	UNII	FDA UNII substance identifier	-	-	openFDA substances
78Q46SZU33	UNII	FDA UNII substance identifier	-	-	openFDA substances
EAQ1VI50KH	UNII	FDA UNII substance identifier	-	-	openFDA substances
EAQ1VI50KH	UNII	FDA UNII substance identifier	-	-	openFDA substances
EAQ1VI50KH	UNII	FDA UNII substance identifier	-	-	openFDA substances
EAQ1VI50KH	UNII	FDA UNII substance identifier	-	-	openFDA substances
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
3240	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
=4900	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
120	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
3	unitless	Relative reliability score	Dermal	Human	NTP_ICE_skin_sensitization

Showing 13 of 13 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Benzyl 2-methoxy-4-prop-1-enylphenyl ether	204-370-6	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for 1-Benzyloxy-2-methoxy-4-(1-propenyl)benzene?

1-Benzyloxy-2-methoxy-4-(1-propenyl)benzene has 13 NOAEL studies in the database. The lowest reported value is 78Q46SZU33 UNII. Source: openFDA substances.

What regulatory lists include 1-Benzyloxy-2-methoxy-4-(1-propenyl)benzene?

1-Benzyloxy-2-methoxy-4-(1-propenyl)benzene appears on 4 regulatory/inventory lists including Europe, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.

Is 1-Benzyloxy-2-methoxy-4-(1-propenyl)benzene used in cosmetics?

Yes, 1-Benzyloxy-2-methoxy-4-(1-propenyl)benzene is also indexed as a cosmetic ingredient under the name Benzyl Isoeugenol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1-Benzyloxy-2-methoxy-4-(1-propenyl)benzene come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 1-Benzyloxy-2-methoxy-4-(1-propenyl)benzene have different safety status in cosmetics vs industrial chemicals?

1-Benzyloxy-2-methoxy-4-(1-propenyl)benzene is prohibited in EU cosmetics but has active industrial GHS classifications.

Is 1-Benzyloxy-2-methoxy-4-(1-propenyl)benzene used outside industrial chemicals?

1-Benzyloxy-2-methoxy-4-(1-propenyl)benzene also appears in cosmetics, food safety, cannabis databases.