Danger GHS08 NOAEL Data REACH Registered Cosmetic Ingredient

2,2'-Methylenebis(4-methyl-6-tert-butylphenol)

Also known as: 2,2'-Methanediylbis(6-tert-butyl-4-methylphenol), 4-06-00-06801, Alterungsschutzmittel BKF, Antioxidant NG-2246, AO 1 (+15 more)

CAS 119-47-1

2,2'-Methylenebis(4-methyl-6-tert-butylphenol) (CAS 119-47-1) is a chemical substance with GHS signal word Danger; key hazard signal: H360F. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Methylene Di-t-Butylcresol →

Cross-Vertical Regulatory Divergence

2,2'-Methylenebis(4-methyl-6-tert-butylphenol) is classified GHS Danger (H360F) in the chemicals database but is restricted in EU cosmetics at max 0.5%.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

2,2'-Methylenebis(4-methyl-6-tert-butylphenol)

CAS Number

119-47-1

DTXSID

DTXSID4020870

Molecular Formula

C23H32O2

InChI Key

KGRVJHAUYBGFFP-UHFFFAOYSA-N

Monoisotopic Mass

340.24023

Synonyms

2,2'-Methanediylbis(6-tert-butyl-4-methylphenol)4-06-00-06801Alterungsschutzmittel BKFAntioxidant NG-2246AO 1Bisaklofen BPBRN 2062676p-Cresol, 2,2'-methylenebis(6-tert-butyl-Di(2-hydroxy-5-methyl-3-tert-butylphenyl)methaneEINECS 204-327-1Methane, 2,2'-bis(6-tert-butyl-p-cresyl)-Methylene bis methyl butyl phenol

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Repr. 1B	H360F	GHS08	Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 29 records

AntioxidantFragranceHeat stabilizer

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 6 records

List	Keyword	Source
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
drinking_water; Europe; manufacturing; plastic_additive	Belgaqua	CPCat
Europe; plastic_additive	European Chemicals Agency	European Chemicals Agency (ECHA)
Europe	European Chemicals Agency	European Chemicals Agency (ECHA)
IFRA Transparency	IFRA	IFRA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 42 of 42 studies

Value	Unit	Endpoint	Route	Species	Source
17.358300750473	uM	AC50	-	-	NTP_ICE_endocrine
37.1817167700206	uM	AC50	-	-	NTP_ICE_endocrine
15.5923196284655	uM	ACC	-	-	NTP_ICE_endocrine
25.0286813999498	uM	ACC	-	-	NTP_ICE_endocrine
22.4	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
=1.25	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
KVM0X4X57B	UNII	FDA UNII substance identifier	-	-	openFDA substances
KVM0X4X57B	UNII	FDA UNII substance identifier	-	-	openFDA substances
KVM0X4X57B	UNII	FDA UNII substance identifier	-	-	openFDA substances
KVM0X4X57B	UNII	FDA UNII substance identifier	-	-	openFDA substances
2.14e-8	fraction	Fu	-	Human	NTP_ICE_adme_parameters
=6.6	mg/kg bw/day	LOAEL	oral	Dog	ToxValDB_ECHA_IUCLID
>=40	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=42.3	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=50	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=54.2	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
<=60	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=75.65	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=88	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=113.16	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=200	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=345.4	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
>=371	mg/kg bw/day	LOAEL	oral	Mouse	ToxValDB_ECHA_IUCLID
<=447	mg/kg bw/day	LOAEL	oral	Mouse	ToxValDB_ECHA_IUCLID
=618	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
-	unitless	Model Score	-	-	NTP_ICE_endocrine
0.00113	unitless	Model Score	-	-	NTP_ICE_endocrine
0.234	unitless	Model Score	-	-	NTP_ICE_endocrine
=4	mg/kg bw/day	NOAEL	oral	Dog	ToxValDB_ECHA_IUCLID
=12.5	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=12.7	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=15.1	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=24.91	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=31.3	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=50	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=54.2	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=104	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=104	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=113.16	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=800	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
<0.12	%	NOEL	oral	Rat	ToxValDB_HESS
=1.92	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_HESS

Showing 42 of 42 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol	204-327-1	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

0.5%

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL460648

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for 2,2'-Methylenebis(4-methyl-6-tert-butylphenol)?

2,2'-Methylenebis(4-methyl-6-tert-butylphenol) (CAS 119-47-1) is classified under EU CLP Annex VI as Repr. 1B with signal word Danger. Hazard statements: H360F. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 2,2'-Methylenebis(4-methyl-6-tert-butylphenol)?

2,2'-Methylenebis(4-methyl-6-tert-butylphenol) has 42 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.

What regulatory lists include 2,2'-Methylenebis(4-methyl-6-tert-butylphenol)?

2,2'-Methylenebis(4-methyl-6-tert-butylphenol) appears on 6 regulatory/inventory lists including Indirect additives food contact (10/2018), inert_ingredient; non_food_use; Pesticides, drinking_water; Europe; manufacturing; plastic_additive, and 3 more. Source: EPA CPDat.

Is 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) used in cosmetics?

Yes, 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) is also indexed as a cosmetic ingredient under the name Methylene Di-t-Butylcresol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) have different safety status in cosmetics vs industrial chemicals?

2,2'-Methylenebis(4-methyl-6-tert-butylphenol) is classified GHS Danger (H360F) in the chemicals database but is restricted in EU cosmetics at max 0.5%.

Is 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) used outside industrial chemicals?

2,2'-Methylenebis(4-methyl-6-tert-butylphenol) also appears in cosmetics, pharmaceutical databases.