What is the NOAEL for N,N-Dimethyl-methanamine-N-oxide?
N,N-Dimethyl-methanamine-N-oxide has 7 NOAEL studies in the database. The lowest reported value is 0.6 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
N,N-Dimethyl-methanamine-N-oxide
Also known as: Trimethylamine Oxide, Trimethylamine, N-oxide, EINECS 214-675-6, UNII-FLD0K1SJ1A, Trimethylammonium oxide (+12 more)
CAS 1184-78-7
N,N-Dimethyl-methanamine-N-oxide (CAS 1184-78-7) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
7
SOURCE
Chemical inventory jurisdictions
Regulatory lists
3
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
23 fields
Name
N,N-Dimethyl-methanamine-N-oxide
CAS Number
1184-78-7
DTXSID
DTXSID8049678
Molecular Formula
C3H9NO
InChI Key
UYPYRKYUKCHHIB-UHFFFAOYSA-N
Monoisotopic Mass
75.068414
Synonyms
Trimethylamine OxideTrimethylamine, N-oxideEINECS 214-675-6UNII-FLD0K1SJ1ATrimethylammonium oxide(CH3)3NOMe3N(+)O(-)Me3N(O)N(CH3)3ON,N-dimethylmethanamine oxideTMA-oxideTMAO
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Flavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| fracking; water | NY Department of Conservation | CPCat |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.6 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| FLD0K1SJ1A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FLD0K1SJ1A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FLD0K1SJ1A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FLD0K1SJ1A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =150 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =300 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Trimethylamine, N-oxide | 214-675-6 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Humectant
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include N,N-Dimethyl-methanamine-N-oxide?
N,N-Dimethyl-methanamine-N-oxide appears on 3 regulatory/inventory lists including fracking; water, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is N,N-Dimethyl-methanamine-N-oxide used in cosmetics?
Yes, N,N-Dimethyl-methanamine-N-oxide is also indexed as a cosmetic ingredient under the name Trimethylamine Oxide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for N,N-Dimethyl-methanamine-N-oxide come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is N,N-Dimethyl-methanamine-N-oxide used outside industrial chemicals?
N,N-Dimethyl-methanamine-N-oxide also appears in cosmetics, cannabis databases.