What is the GHS hazard classification for Di(2-ethylhexyl) phthalate?
Di(2-ethylhexyl) phthalate (CAS 117-81-7) is classified under EU CLP Annex VI as Repr. 1B with signal word Danger. Hazard statements: H360FD. Source: EU CLP Annex VI (ECHA).
Danger
GHS08
NOAEL Data
IARC Group 2B
SVHC
Prop 65
REACH Registered
Cosmetic Ingredient
Di(2-ethylhexyl) phthalate
Also known as: 1,2-Benzenedicarboxylic acid, bis(2-ethylhexyl) ester, DEHP, Bis-(2-ethylhexyl)-phthalate, di(alpha-Ethylhexyl) phthalate, 2-Ethylhexyl phthalate (+15 more)
CAS 117-81-7
Di(2-ethylhexyl) phthalate (CAS 117-81-7) is a chemical substance with GHS signal word Danger; key hazard signal: H360FD. Key regulatory status: SVHC Candidate List, California Proposition 65, REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ECHA SVHC, CA Prop 65, ILO ICSC, OSHA, EPA TRI.
View cosmetic safety profile for Diethylhexyl Phthalate (DEHP) →
Cross-Vertical Regulatory Divergence
Di(2-ethylhexyl) phthalate is prohibited in EU cosmetics but has active industrial GHS classifications (H360FD).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
100
SOURCE
chemical inventory jurisdictions
Regulatory lists
60
SOURCE
eu clp annex vi
GHS signal
Danger
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Di(2-ethylhexyl) phthalate
CAS Number
117-81-7
DTXSID
DTXSID5020607
Molecular Formula
C24H38O4
InChI Key
BJQHLKABXJIVAM-UHFFFAOYSA-N
Monoisotopic Mass
390.27701
Synonyms
1,2-Benzenedicarboxylic acid, bis(2-ethylhexyl) esterDEHPBis-(2-ethylhexyl)-phthalatedi(alpha-Ethylhexyl) phthalate2-Ethylhexyl phthalateDi-(2-ethylhexyl) phthalateDioctylphthalateBRN 1890696Caswell No. 392KCompound 889Di(2-ethylhexyl) orthophthalateDi(2-ethylhexyl)orthophthalate
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 2B | Possibly carcinogenic | 2011 | Sup 7, 77, 101 |
Substance of Very High Concern (SVHC)
Candidate List status and reason under the ECHA REACH SVHC program.
SOURCE
ECHA (EU)
1 records
| Substance | Reason | Included |
|---|---|---|
| Bis (2-ethylhexyl)phthalate (DEHP) | Toxic for reproduction (Article 57c); Endocrine disrupting properties (Article 57(f) - environment); Endocrine disrupting properties (Article 57(f) - human health) | 28-Oct-2008 |
California Proposition 65
California OEHHA listing status and toxicity category.
SOURCE
California OEHHA Proposition 65 List
8 records
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
| - | developmental, male | No | Yes | - |
| - | developmental, male | No | Yes | - |
| - | developmental, male | No | Yes | - |
| - | developmental, male | No | Yes | - |
| - | developmental, male | No | Yes | - |
| - | developmental, male | No | Yes | - |
| - | developmental, male | No | Yes | - |
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Repr. 1B | H360FD | GHS08 | Danger |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes and respiratory tract. |
| Long-term Effects | The substance may have effects on the testes. Animal tests show that this substance possibly causes toxicity to human reproduction or development. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation, through the skin and by ingestion. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
6 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 5 mg/m³ | - | 5 | N |
| NIOSH | TWA | 5 mg/m³ | - | 5 | N |
| NIOSH | STEL | 10 mg/m³ | - | 10 | N |
| ACGIH | TWA | 5 mg/m³ [1996] | - | 5 | N |
| CAL/OSHA | TWA | 5 mg/m³ | - | 5 | N |
| NIOSH | IDLH | 5000 mg/m³ | - | 5000 | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
51 records
SolventPlasticizerDeodorizerFragranceDegradant/impurityCatalyst
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
60 records
| List | Keyword | Source |
|---|---|---|
| banned; Europe; Personal care | European Commission | CosIng |
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| detected; emissions; Europe; Other indirect contact consumer goods; water | Danish Environmental Protection Agency | Danish EPA |
| detected; Toys and children's products | American Public Health Association | Published Articles |
| Arts and crafts/Office supplies - children's art and toys - modeling clay; detected | Springer | Published Articles |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| fracking; water | NY Department of Conservation | CPCat |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| detected; Other direct contact consumer goods; Toys and children's products | Reproductive Toxicology | Published Articles |
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
| detected; Europe; Other direct contact consumer goods; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| children | Vermont Department of Health | State of Vermont |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| children | Oregon Health Authority | State of Oregon |
| children; WA Children's Safe Product Act (4/2020) | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Personal care - child specific; Personal care - specialized bath products - bubble bath; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| children; detected; Personal care - make-up and related; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| children; detected; Personal care - body hygiene - body wash; Personal care - fragrance | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| detected; Toys and children's products | State of Washington Department of Ecology | State of Washington |
| children; detected; Packaging (non-food contact) | State of Washington Department of Ecology | State of Washington |
| active_ingredient; Pesticides | State of California | State of California |
| consumer_product | P&G | Proctor & Gamble |
| Europe; Food contact items | Danish Environmental Protection Agency | Danish EPA |
| drinking_water; Europe; soil | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 6170 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| >100000 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 190000 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 428000 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| 450000 | nM | AC50/EC50/IC50 | - | - | NTP_ICE_endocrine |
| =3.8 | mg/kg bw/day | BMDL | oral | Rat | ToxValDB_MN_MDH_HHBW |
| ABoral=410 (adult); 58 (infant boys, age 29 days to 24 months); 20 (neonatal infant boys, age 0 to 28 days); Adultb: 4200 (intravenous); Infant boys, age 29 days to 24 monthsb: 600 (intravenous); Neonatal infant boys, age 0 to 28 daysb: 210 (intravenous); Adultb: oral=410; Infant boys, age 29 days to 24 monthsb: oral=58; Neonatal infant boys, age 0 to 28 daysb: oral=20 | ug/day | California Proposition 65 MADL | - | - | California Proposition 65 |
| ABoral=410 (adult); 58 (infant boys, age 29 days to 24 months); 20 (neonatal infant boys, age 0 to 28 days); Adultb: 4200 (intravenous); Infant boys, age 29 days to 24 monthsb: 600 (intravenous); Neonatal infant boys, age 0 to 28 daysb: 210 (intravenous); Adultb: oral=410; Infant boys, age 29 days to 24 monthsb: oral=58; Neonatal infant boys, age 0 to 28 daysb: oral=20 | ug/day | California Proposition 65 MADL | - | - | California Proposition 65 |
| ABoral=410 (adult); 58 (infant boys, age 29 days to 24 months); 20 (neonatal infant boys, age 0 to 28 days); Adultb: 4200 (intravenous); Infant boys, age 29 days to 24 monthsb: 600 (intravenous); Neonatal infant boys, age 0 to 28 daysb: 210 (intravenous); Adultb: oral=410; Infant boys, age 29 days to 24 monthsb: oral=58; Neonatal infant boys, age 0 to 28 daysb: oral=20 | ug/day | California Proposition 65 MADL | - | - | California Proposition 65 |
| SQE310 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQE310 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQE310 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABdevelopmental, male | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABdevelopmental, male | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABdevelopmental, male | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| 2.646 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| 10.73 | uL/min/10^6 cells | Clint | - | Rat | NTP_ICE_adme_parameters |
| =1.6 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| C42K0PH13C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C42K0PH13C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C42K0PH13C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C42K0PH13C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| 0.2152 | fraction | Fu | - | Rat | NTP_ICE_adme_parameters |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2 | unitless | IARC group | - | - | NTP_ICE_cancer |
| >20000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >25000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =30000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =0.05 | mg/kg bw/day | LEL | oral | rodent | ToxValDB_EPA_TSCA_8e |
| =32.5 | uL/L-day | LEL | oral | Rat | ToxValDB_EPA_TSCA_8e |
| =48 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_EPA_TSCA_8e |
| =100 | ppm | LEL | oral | Rat | ToxValDB_EPA_TSCA_8e |
| =100 | mg/kg bw/day | LEL | oral | rodent | ToxValDB_EPA_TSCA_8e |
| =288 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_EPA_TSCA_8e |
| =325 | uL/L-day | LEL | oral | Rat | ToxValDB_EPA_TSCA_8e |
| =357 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =357 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =500 | ppm | LEL | oral | Rat | ToxValDB_EPA_TSCA_8e |
| =500 | mg/kg bw/day | LEL | oral | Rabbit | ToxValDB_EPA_TSCA_8e |
| =591 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_EPA_TSCA_8e |
| =600 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =600 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =666 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =750 | mg/kg bw/day | LEL | oral | Rabbit | ToxValDB_EPA_TSCA_8e |
Showing 50 of 100 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Bis(2-ethylhexyl) phthalate | 204-211-0 | ECHA overview → |
EPA Toxic Release Inventory (TRI)
TRI hazard and reporting flags for the matched chemical.
SOURCE
EPA Toxics Release Inventory (TRI) chemical list
1 records
| Chemical | Category | Flags |
|---|---|---|
| Di(2-ethylhexyl) phthalate | - | - |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. These obligations are: 1. A person introducing this chemical must tell us in writing within 28 calendar days if any of the following circumstances have occurred in relation to their introduction (importation or manufacture): a. Additional information becoming available on the adverse health effects of DEHP. 2. A person who introduces this chemical must tell us in writing within 28 calendar days if they become aware of any of the following circumstances, namely, that since the assessment under the Industrial Chemicals (Notification and Assessment) Act 1989: a. the function or use of the chemical has changed, or is likely to change, significantly; b. the amount of the chemical being introduced has increased, or is likely to increase, significantly; c. in the case of a chemical not manufactured, or proposed to be manufactured, in Australia at the time of the assessment—it has begun to be manufactured in Australia; d. the method of manufacture of the chemical in Australia has changed, or is likely to change, in a way that may result in an increased risk of an adverse effect of the chemical on occupational health and safety, public health or the environment; e. additional information has become available to the person as to an adverse effect of the chemical on occupational health and safety, public health or the environment.
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
BIS(2-ETHYLHEXYL) PHTHALATE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
3
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: 50 mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Di(2-ethylhexyl) phthalate?
Di(2-ethylhexyl) phthalate has 100 NOAEL studies in the database. The lowest reported value is 0.03 % diet via oral in Mouse. Source: ToxValDB_EPA_TSCA_8e.
What regulatory lists include Di(2-ethylhexyl) phthalate?
Di(2-ethylhexyl) phthalate appears on 35 regulatory/inventory lists including banned; Europe; Personal care, detected; Europe; Vehicle - car interior, detected; emissions; Europe; Other indirect contact consumer goods; water, and 32 more. Source: EPA CPDat.
Is Di(2-ethylhexyl) phthalate a carcinogen according to IARC?
Di(2-ethylhexyl) phthalate is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 2011). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Di(2-ethylhexyl) phthalate on the California Proposition 65 list?
Yes, Di(2-ethylhexyl) phthalate is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Is Di(2-ethylhexyl) phthalate a Substance of Very High Concern (SVHC)?
Yes, Di(2-ethylhexyl) phthalate is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: Toxic for reproduction (Article 57c); Endocrine disrupting properties (Article 57(f) - environment); Endocrine disrupting properties (Article 57(f) - human health). Source: ECHA SVHC Candidate List.
What are the occupational exposure limits for Di(2-ethylhexyl) phthalate?
Occupational exposure limits for Di(2-ethylhexyl) phthalate are set by OSHA, NIOSH, ACGIH. 6 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Di(2-ethylhexyl) phthalate used in cosmetics?
Yes, Di(2-ethylhexyl) phthalate is also indexed as a cosmetic ingredient under the name Diethylhexyl Phthalate (DEHP). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Di(2-ethylhexyl) phthalate come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ECHA SVHC Candidate List, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Di(2-ethylhexyl) phthalate have different safety status in cosmetics vs industrial chemicals?
Di(2-ethylhexyl) phthalate is prohibited in EU cosmetics but has active industrial GHS classifications (H360FD).
Is Di(2-ethylhexyl) phthalate used outside industrial chemicals?
Di(2-ethylhexyl) phthalate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.