What is the NOAEL for Linalyl acetate?
Linalyl acetate has 31 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP ICE skin sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Linalyl acetate
Also known as: 1,6-Octadien-3-ol, 3,7-dimethyl-, acetate, 3,7-Dimethyl-1,6-octadien-3-ol acetate, EINECS 204-116-4, EINECS 254-806-4, FEMA No. 2636 (+4 more)
CAS 115-95-7
Linalyl acetate (CAS 115-95-7) is a chemical substance. Key regulatory status: REACH registered, 12 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
NOAEL studies
NOAEL studies
31
SOURCE
Chemical inventory jurisdictions
Regulatory lists
12
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
Linalyl acetate
CAS Number
115-95-7
DTXSID
DTXSID7026946
Molecular Formula
C12H20O2
InChI Key
UWKAYLJWKGQEPM-UHFFFAOYSA-N
Monoisotopic Mass
196.14633
Synonyms
1,6-Octadien-3-ol, 3,7-dimethyl-, acetate3,7-Dimethyl-1,6-octadien-3-ol acetateEINECS 204-116-4EINECS 254-806-4FEMA No. 2636Licareol acetateLinalol acetateLynalyl acetateUNII-5K47SSQ51G
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
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WHO/JECFA
1 records
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | Combustible liquid Causes eye irritation Toxic to aquatic life |
| Short-term Effects | The substance is mildly irritating to the eyes. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceDeodorizerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
12 records
| List | Keyword | Source |
|---|---|---|
| Cleaning products and household care - air freshener; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 31 of 31 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| <=0.5 | mg/kg | ADI | oral | Human | WHO/JECFA |
| 5.5 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 13 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 5 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| 10 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| =2.75 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 5K47SSQ51G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5K47SSQ51G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5K47SSQ51G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 5K47SSQ51G | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 3.846 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 9.091 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 6480 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 6750 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 7448 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 13500 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 3564 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 8775 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 3240 | ug/cm2 | Induction dose per skin area, one positive response | Dermal | Human | NTP ICE skin sensitization |
| - | unitless | Model Score | - | - | NTP ICE endocrine |
| 1.6 | % | Positive reaction | Dermal | Human | NTP ICE skin irritation |
| 2 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
| 43.15 | % | Viability | Dermal | - | NTP ICE skin irritation |
| 71.65 | % | Viability | Dermal | - | NTP ICE skin irritation |
| 90 | % | Viability | Dermal | - | NTP ICE skin irritation |
| 97.1 | % | Viability | Dermal | - | NTP ICE skin irritation |
| 97.8 | % | Viability | Dermal | - | NTP ICE skin irritation |
| 117.8 | % | Viability (18 hours) | Dermal | - | NTP ICE skin irritation |
| 52.5 | % | Viability (42 hours) | Dermal | - | NTP ICE skin irritation |
Showing 31 of 31 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Linalyl acetate | 204-116-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.001% (leave-on) / 0.01% (rinse-off) - declarable allergen under EU 2023/1545
Category
fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
LINALYL ACETATE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Linalyl acetate?
Linalyl acetate appears on 10 regulatory/inventory lists including Cleaning products and household care - air freshener; Europe, air; detected; emissions; Europe; Vehicle - car interior, detected; Europe; Vehicle - car interior, and 7 more. Source: EPA CPDat.
Is Linalyl acetate used in cosmetics?
Yes, Linalyl acetate is also indexed as a cosmetic ingredient under the name Linalyl Acetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Linalyl acetate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Linalyl acetate used outside industrial chemicals?
Linalyl acetate also appears in cosmetics, pharmaceutical, cannabis databases.