What is the NOAEL for Oleic acid?
Oleic acid has 14 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.
NOAEL Data
Cosmetic Ingredient
Oleic acid
Also known as: 9-Octadecenoic acid (9Z)-, Z-(9)-Octadecenoic acid, 9-Octadecenoic acid, EC No.: 204-007-1, 4-02-00-01641 (+15 more)
CAS 112-80-1
Oleic acid (CAS 112-80-1) is a chemical substance. Key regulatory status: 35 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ILO ICSC.
SOURCE
NOAEL studies
NOAEL studies
14
SOURCE
Chemical inventory jurisdictions
Regulatory lists
35
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Oleic acid
CAS Number
112-80-1
DTXSID
DTXSID1025809
Molecular Formula
C18H34O2
InChI Key
ZQPPMHVWECSIRJ-KTKRTIGZSA-N
Monoisotopic Mass
282.25588
Synonyms
9-Octadecenoic acid (9Z)-Z-(9)-Octadecenoic acid9-Octadecenoic acidEC No.: 204-007-14-02-00-01641BRN 1726542Caswell No. 619EINECS 204-007-1EPA Pesticide Chemical Code 031702FEMA No. 2815FEMA Number 2815Hy-phi 1055
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
WHO/JECFA
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is mildly irritating to the eyes and skin. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Surfactant (surface active agent)Lubricating agentSoftener and conditionerEmulsifierNo specific technical functionFragranceFlavouring and nutrientAnti-adhesive/cohesiveSolventpH regulating agentBinderCleaning agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
35 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Arts and crafts/Office supplies - home office - pens and markers; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 14 of 14 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 240 | min | Breakthrough Time | Dermal | - | NTP ICE skin irritation |
| 10.5 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 10.5 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 10.5 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 10.5 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 2UMI9U37CP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2UMI9U37CP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2UMI9U37CP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2UMI9U37CP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =0.09 | mM | LOEL | environmental | European Rabbit | ToxValDB ECOTOX |
| - | unitless | Model Score | - | - | NTP ICE endocrine |
| =0.9 | mM | NOEL | environmental | European Rabbit | ToxValDB ECOTOX |
| 10.6 | kiloohms | TER | Dermal | - | NTP ICE skin irritation |
| 18.5 | kiloohms | TER | Dermal | - | NTP ICE skin irritation |
Showing 14 of 14 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
emollient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
OLEIC ACID
ChEMBL Phase
2
Adverse Events
0
Bioactivity
26
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Frequently Asked Questions
What regulatory lists include Oleic acid?
Oleic acid appears on 14 regulatory/inventory lists including pharmaceutical, active_ingredient; Pesticides, inert_ingredient; Pesticides, and 11 more. Source: EPA CPDat.
Is Oleic acid used in cosmetics?
Yes, Oleic acid is also indexed as a cosmetic ingredient under the name Oleic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Oleic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Oleic acid used outside industrial chemicals?
Oleic acid also appears in cosmetics, pharmaceutical, food safety databases.