What is the NOAEL for 1-Dodecanol?
1-Dodecanol has 25 NOAEL studies in the database. The lowest reported value is 155 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1-Dodecanol
Also known as: Lauryl alcohol, C12 alcohol, 4-01-00-01844, BRN 1738860, Cachalot L-50 (+15 more)
CAS 112-53-8
1-Dodecanol (CAS 112-53-8) is a chemical substance. Key regulatory status: REACH registered, 28 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Cross-Vertical Regulatory Divergence
1-Dodecanol is classified GHS Danger (H319, H400, H410, H411, H320, H370, H412, H371) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
25
SOURCE
chemical inventory jurisdictions
Regulatory lists
28
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
1-Dodecanol
CAS Number
112-53-8
DTXSID
DTXSID5026918
Molecular Formula
C12H26O
InChI Key
LQZZUXJYWNFBMV-UHFFFAOYSA-N
Monoisotopic Mass
186.198365
Synonyms
Lauryl alcoholC12 alcohol4-01-00-01844BRN 1738860Cachalot L-50Cachalot L-90EINECS 203-982-0Fatty alcohol(C12)FEMA No. 2617FEMA Number 2617n-Lauryl alcohol, primaryUNII-178A96NLP2
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | Causes skin and eye irritation May cause respiratory irritation May be harmful if swallowed and enters airways Very toxic to aquatic life with long lasting effects |
| Short-term Effects | The substance is irritating to the skin, eyes and possibly the respiratory tract. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis. |
| Long-term Effects | See Notes. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation, through the skin and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
57 records
DefoamerStabilizing agentSoftener and conditionerEmulsifierViscosity modifierDegradant/impurityThickening agentFragranceSurfactant (surface active agent)Flavouring and nutrientPlasticizerSolventLubricating agentChemical reaction regulator
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
28 records
| List | Keyword | Source |
|---|---|---|
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Food contact items | Washington State Department of Ecology | State of Washington |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| Europe | European Commission | Fl@vis |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 25 of 25 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =155 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =313 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 178A96NLP2 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 178A96NLP2 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 178A96NLP2 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 178A96NLP2 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2592 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >0.7 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >1.5 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >2.05 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >21 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >71 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >12800 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >26530 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =100 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HPVIS |
| =300 | mg/kg bw/day | NOAEL | dermal | Mouse | ToxValDB_ECHA_IUCLID |
| =800 | mg/kg bw/day | NOAEL | dermal | Mouse | ToxValDB_ECHA_IUCLID |
| =2000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 3324 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| <100 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| - | % | Positive reaction | Dermal | Human | NTP_ICE_skin_irritation |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 25 of 25 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dodecan-1-ol | 203-982-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Emulsifier
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
DODECANOL
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 1-Dodecanol?
1-Dodecanol appears on 13 regulatory/inventory lists including Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe, SCIL (9/2019), Canada; pharmaceutical, and 10 more. Source: EPA CPDat.
Is 1-Dodecanol used in cosmetics?
Yes, 1-Dodecanol is also indexed as a cosmetic ingredient under the name Lauryl Alcohol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1-Dodecanol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 1-Dodecanol have different safety status in cosmetics vs industrial chemicals?
1-Dodecanol is classified GHS Danger (H319, H400, H410, H411, H320, H370, H412, H371) in the chemicals database but is allowed in EU cosmetics.
Is 1-Dodecanol used outside industrial chemicals?
1-Dodecanol also appears in cosmetics, pharmaceutical, cannabis databases.