What is the NOAEL for Dodecane?
Dodecane has 13 NOAEL studies in the database. The lowest reported value is 2 unitless via Ocular in Rabbit. Source: NTP_ICE_eye_irritation.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Dodecane
Also known as: Adakane 12, Cactus Normal Paraffin N 12D, Parafol 12-97, Parafol C12-97, n-Dodecane (+11 more)
CAS 112-40-3
Dodecane (CAS 112-40-3) is a chemical substance. Key regulatory status: REACH registered, 15 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Dodecane is classified GHS Danger (H304, H319, H227, H226, H410, H413) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
13
SOURCE
chemical inventory jurisdictions
Regulatory lists
15
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
22 fields
Name
Dodecane
CAS Number
112-40-3
DTXSID
DTXSID0026913
Molecular Formula
C12H26
InChI Key
SNRUBQQJIBEYMU-UHFFFAOYSA-N
Monoisotopic Mass
170.203451
Synonyms
Adakane 12Cactus Normal Paraffin N 12DParafol 12-97Parafol C12-97n-DodecaneC12-n-Alkane4-01-00-00498BRN 1697175EINECS 203-967-9n-DodecanUNII-11A386X1QHBihexyl
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
7 records
FragranceSolventFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
15 records
| List | Keyword | Source |
|---|---|---|
| detected; Other direct contact consumer goods; Other indirect contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - laundry and fabric treatment; detected; emissions | Elsevier | CPCat |
| air; Cleaning products and household care; detected; emissions | Elsevier | CPCat |
| air; Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 2 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 3 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 11A386X1QH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 11A386X1QH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 11A386X1QH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 11A386X1QH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.02 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| >0.9887 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >15000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =41801.4 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| >180 | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| - | % | Plateau level | Ocular | - | NTP_ICE_eye_irritation |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dodecane | 203-967-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Emollient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
DODECANE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Dodecane?
Dodecane appears on 12 regulatory/inventory lists including detected; Other direct contact consumer goods; Other indirect contact consumer goods, Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe, Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe, and 9 more. Source: EPA CPDat.
Is Dodecane used in cosmetics?
Yes, Dodecane is also indexed as a cosmetic ingredient under the name Dodecane. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dodecane come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Dodecane have different safety status in cosmetics vs industrial chemicals?
Dodecane is classified GHS Danger (H304, H319, H227, H226, H410, H413) in the chemicals database but is allowed in EU cosmetics.
Is Dodecane used outside industrial chemicals?
Dodecane also appears in cosmetics, pharmaceutical, cannabis databases.