Warning GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

2-(2-Butoxyethoxy)ethanol

Also known as: Diethylene glycol monobutyl ether, BRN 1739225, Butoxy diethylene glycol, Caswell No. 121B, Caswell No. 125H (+6 more)

CAS 112-34-5

2-(2-Butoxyethoxy)ethanol (CAS 112-34-5) is a chemical substance with GHS signal word Warning; key hazard signal: H319. Key regulatory status: REACH registered, 23 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH, ILO ICSC, OSHA.

View cosmetic safety profile for Butoxydiglycol →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 17 fields

Name

2-(2-Butoxyethoxy)ethanol

CAS Number

112-34-5

DTXSID

DTXSID8021519

Molecular Formula

C8H18O3

InChI Key

OAYXUHPQHDHDDZ-UHFFFAOYSA-N

Monoisotopic Mass

162.125594

Synonyms

Diethylene glycol monobutyl etherBRN 1739225Butoxy diethylene glycolCaswell No. 121BCaswell No. 125HDiethylene gylcol monobutyl etherEINECS 203-961-6EPA Pesticide Chemical Code 011502Glycol ether DBJeffersol DBUNII-9TB90IYC0E

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Eye Irrit. 2	H319	GHS07	Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	The substance is irritating to the eyes.
Long-term Effects	The substance defats the skin, which may cause dryness or cracking.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 1 records

Agency	Metric	Value	ppm	mg/m3	Skin
ACGIH	TWA	10 ppm (inhalable fraction and vapor) [2012]	10	-	N

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

SolventDeodorizerViscosity modifierFragranceCleaning agentDiluentProcessing aids not otherwise specifiedCoalescing agentNo specific technical functionStabilizing agent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 23 records

List	Keyword	Source
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe	Danish Environmental Protection Agency	Danish EPA
detected; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - home office - pens and markers; detected; Europe	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - fabric treatment and dye; detected	Danish Environmental Protection Agency	Danish EPA
artificial_saliva; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
Europe; Specialty occupational products	Danish Environmental Protection Agency	Danish EPA
Europe; Specialty occupational products	Danish Environmental Protection Agency	Danish EPA
Europe; Specialty occupational products	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Specialty occupational products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other indirect contact consumer goods	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - oven - oven cleaner; Europe	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - oven - oven cleaner; Europe	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - oven - oven cleaner; detected; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
Cleaning products and household care - oven - oven cleaner; Europe	Danish Environmental Protection Agency	Danish EPA
Cleaning products and household care - oven - oven cleaner; detected; Europe	Danish Environmental Protection Agency	Danish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; Europe	Danish Environmental Protection Agency	Danish EPA
SCIL (9/2019)	USEPA	Safer Chemical Ingredients List
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)
IFRA Transparency	IFRA	IFRA
Europe; Personal care; restricted	European Commission	CosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 86 studies

Value	Unit	Endpoint	Route	Species	Source
250	mg/kg bw/day	-	dermal	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
250	mg/kg bw/d	-	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
580	mg/kg bw/day	-	dermal	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
2000	mg/kg	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=0.32	mg/m3	BMCL (10 HEC)	inhalation	Rat	ToxValDB_PPRTV_(CPHEA)
=81	mg/kg bw/day	BMDL	oral	Rat	ToxValDB_PPRTV_(CPHEA)
=67.5	mg/m3	DNEL local	inhalation	Human	ToxValDB_GESTIS_DNEL
9TB90IYC0E	UNII	FDA UNII substance identifier	-	-	openFDA substances
9TB90IYC0E	UNII	FDA UNII substance identifier	-	-	openFDA substances
9TB90IYC0E	UNII	FDA UNII substance identifier	-	-	openFDA substances
9TB90IYC0E	UNII	FDA UNII substance identifier	-	-	openFDA substances
=4500	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
>5000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=5080	mg/kg bw	LD50	oral	Rat (Female)	NTP_ICE_acute_oral
=5660	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=6050	mg/kg bw	LD50	oral	Rat (Female)	NTP_ICE_acute_oral
=6530	mg/kg bw	LD50	oral	Rat (Male)	NTP_ICE_acute_oral
=6560	mg/kg bw	LD50	oral	Rat (Male)	NTP_ICE_acute_oral
=6600	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=7291	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=7292	mg/kg bw	LD50	oral	Rat (Male)	NTP_ICE_acute_oral
=7300	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=9623	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=56398.9	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
=250	mg/kg bw/day	LOAEC	oral	Rat	ToxValDB_ECHA_IUCLID
-	unitless	Model Score	-	-	NTP_ICE_endocrine
=500	mg/kg bw/day	NOAEC	oral	Rat	ToxValDB_ECHA_IUCLID
=2.6	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=2.6	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=2.6	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=2.6	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=50	%	NOAEL	oral	rat	SCCS_vision_codex
=50	%	NOAEL	oral	rat	SCCS_vision_codex
=50	%	NOAEL	oral	rat	SCCS_vision_codex
=50	%	NOAEL	oral	rat	SCCS_vision_codex
=51	mg/kg bw/day	NOAEL	oral	rat	SCCS_vision_codex
=51	mg/kg bw/day	NOAEL	oral	rat	SCCS_vision_codex
=51	mg/kg bw/day	NOAEL	oral	rat	SCCS_vision_codex
=51	mg/kg bw/day	NOAEL	oral	rat	SCCS_vision_codex
=250	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_HESS
=250	mg/kg bw/day	NOAEL	dermal	rat	SCCS_vision_codex
=250	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=250	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=250	mg/kg bw/day	NOAEL	dermal	rat	SCCS_vision_codex
=250	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=250	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=250	mg/kg bw/day	NOAEL	dermal	rat	SCCS_vision_codex
=250	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=250	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=250	mg/kg bw/day	NOAEL	dermal	rat	SCCS_vision_codex

Showing 50 of 86 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	2-(2-butoxyethoxy)ethanol	203-961-6	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCP/0991/06	19 December 2006	safe with restrictions	Various	Solvent; some renal effects at very high doses; acceptable at cosmetic concentrations

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1904721

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for 2-(2-Butoxyethoxy)ethanol?

2-(2-Butoxyethoxy)ethanol (CAS 112-34-5) is classified under EU CLP Annex VI as Eye Irrit. 2 with signal word Warning. Hazard statements: H319. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 2-(2-Butoxyethoxy)ethanol?

2-(2-Butoxyethoxy)ethanol has 86 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.

What regulatory lists include 2-(2-Butoxyethoxy)ethanol?

2-(2-Butoxyethoxy)ethanol appears on 17 regulatory/inventory lists including Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe, detected; Other direct contact consumer goods, Arts and crafts/Office supplies - home office - pens and markers; detected; Europe, and 14 more. Source: EPA CPDat.

What are the occupational exposure limits for 2-(2-Butoxyethoxy)ethanol?

Occupational exposure limits for 2-(2-Butoxyethoxy)ethanol are set by ACGIH. 1 limit value from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is 2-(2-Butoxyethoxy)ethanol used in cosmetics?

Yes, 2-(2-Butoxyethoxy)ethanol is also indexed as a cosmetic ingredient under the name Butoxydiglycol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-(2-Butoxyethoxy)ethanol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is 2-(2-Butoxyethoxy)ethanol used outside industrial chemicals?

2-(2-Butoxyethoxy)ethanol also appears in cosmetics, pharmaceutical databases.