NOAEL Data REACH Registered Cosmetic Ingredient

Hexadecyl trimethyl ammonium chloride

Also known as: Cetyl trimethyl ammonium chloride, 1-Hexadecanaminium, N,N,N-trimethyl-, chloride, Arquad 16/28, Caswell No. 167A, EINECS 203-928-6 (+6 more)

CAS 112-02-7

Hexadecyl trimethyl ammonium chloride (CAS 112-02-7) is a chemical substance. Key regulatory status: REACH registered, 10 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Cetrimonium Chloride →

Cross-Vertical Regulatory Divergence

Hexadecyl trimethyl ammonium chloride is classified GHS Danger (H302, H311, H314, H315, H318, H335, H400, H410) in the chemicals database but is allowed in EU cosmetics at max 0.5–3%.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

100

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 17 fields

Name

Hexadecyl trimethyl ammonium chloride

CAS Number

112-02-7

DTXSID

DTXSID6026901

Molecular Formula

C19H42N.ClH

InChI Key

WOWHHFRSBJGXCM-UHFFFAOYSA-M

Monoisotopic Mass

320.308403

Synonyms

Cetyl trimethyl ammonium chloride1-Hexadecanaminium, N,N,N-trimethyl-, chlorideArquad 16/28Caswell No. 167AEINECS 203-928-6EPA Pesticide Chemical Code 069133UNII-UC9PE95IBPCTACTrimethylhexadecylammonium chloridecetyl(trimethyl)ammonium chloridehexadecyl(trimethyl)ammonium chloride

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

Surfactant (surface active agent)Softener and conditionerAnti-caking agentBiocidePreservativeAnti-static agentEmulsifier

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 10 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
children; Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
inert_ingredient; non_food_use; Pesticides	EPA	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies

Value	Unit	Endpoint	Route	Species	Source
=0.052	mg/kg bw/day	-	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
3.3	-	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=10	mg/kg bw/day	-	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
54	-	-	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
UC9PE95IBP	UNII	FDA UNII substance identifier	-	-	openFDA substances
UC9PE95IBP	UNII	FDA UNII substance identifier	-	-	openFDA substances
UC9PE95IBP	UNII	FDA UNII substance identifier	-	-	openFDA substances
UC9PE95IBP	UNII	FDA UNII substance identifier	-	-	openFDA substances
=450	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=699	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=861	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=10	mg/kg bw/day	LOAEL	dermal	Rabbit	ToxValDB_ECHA_IUCLID
=400	mg/kg bw/day	LOEL	oral	Mouse	ToxValDB_ECOTOX
=600	mg/kg bw/day	LOEL	oral	Mouse	ToxValDB_ECOTOX
=0.052	mg/kg bw/day	NOAEL	oral	rat	SCCS_vision_codex
=0.052	mg/kg bw/day	NOAEL	oral	rat	SCCS_vision_codex
=0.052	mg/kg bw/day	NOAEL	oral	rat	SCCS_vision_codex
=0.052	mg/kg bw/day	NOAEL	oral	rat	SCCS_vision_codex
=0.8	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=0.8	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=0.8	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=0.8	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=2.5	%	NOAEL	dermal	rat	SCCS_vision_codex
=2.5	%	NOAEL	dermal	rat	SCCS_vision_codex
=2.5	%	NOAEL	dermal	rat	SCCS_vision_codex
=2.5	%	NOAEL	dermal	rat	SCCS_vision_codex
=3.3	-	NOAEL	-	-	SCCS_vision_codex
=3.3	-	NOAEL	-	-	SCCS_vision_codex
=3.3	-	NOAEL	-	-	SCCS_vision_codex
=3.3	-	NOAEL	-	-	SCCS_vision_codex
=9.9	%	NOAEL	dermal	-	SCCS_vision_codex
=9.9	%	NOAEL	dermal	-	SCCS_vision_codex
=9.9	%	NOAEL	dermal	-	SCCS_vision_codex
=9.9	%	NOAEL	dermal	-	SCCS_vision_codex
=10	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=10	mg/kg bw/day	NOAEL	oral	-	SCCS_vision_codex
=10	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=10	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=10	mg/kg bw/day	NOAEL	oral	-	SCCS_vision_codex
=10	mg/kg bw/day	NOAEL	oral	-	SCCS_vision_codex
=10	mg/kg	NOAEL	oral	rat	SCCS_vision_codex
=10	mg/kg bw/day	NOAEL	oral	-	SCCS_vision_codex
=12.5	mg/kg bw/day	NOAEL	dermal	rat	SCCS_vision_codex
=12.5	mg/kg bw/day	NOAEL	dermal	rat	SCCS_vision_codex
=12.5	mg/kg bw/day	NOAEL	dermal	rat	SCCS_vision_codex
=12.5	mg/kg bw/day	NOAEL	dermal	rat	SCCS_vision_codex
=24	%	NOAEL	dermal	rabbit	SCCS_vision_codex
=24	%	NOAEL	dermal	rabbit	SCCS_vision_codex
=24	%	NOAEL	dermal	rabbit	SCCS_vision_codex
=24	%	NOAEL	dermal	rabbit	SCCS_vision_codex

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Cetrimonium chloride	203-928-6	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

0.5–3%

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL HEXADECYLTRIMETHYLAMMONIUM CHLORIDE

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for Hexadecyl trimethyl ammonium chloride?

Hexadecyl trimethyl ammonium chloride has 100 NOAEL studies in the database. The lowest reported value is 0.052 mg/kg bw/day via oral in rat. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.

What regulatory lists include Hexadecyl trimethyl ammonium chloride?

Hexadecyl trimethyl ammonium chloride appears on 5 regulatory/inventory lists including Europe; Personal care; restricted, children; Europe; Personal care, Europe; Personal care, and 2 more. Source: EPA CPDat.

Is Hexadecyl trimethyl ammonium chloride used in cosmetics?

Yes, Hexadecyl trimethyl ammonium chloride is also indexed as a cosmetic ingredient under the name Cetrimonium Chloride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Hexadecyl trimethyl ammonium chloride come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Hexadecyl trimethyl ammonium chloride have different safety status in cosmetics vs industrial chemicals?

Hexadecyl trimethyl ammonium chloride is classified GHS Danger (H302, H311, H314, H315, H318, H335, H400, H410) in the chemicals database but is allowed in EU cosmetics at max 0.5–3%.

Is Hexadecyl trimethyl ammonium chloride used outside industrial chemicals?

Hexadecyl trimethyl ammonium chloride also appears in cosmetics, pharmaceutical databases.