What is the NOAEL for Dodecyltrimethylammonium chloride?
Dodecyltrimethylammonium chloride has 14 NOAEL studies in the database. The lowest reported value is 9.45635249707941 uM. Source: NTP_ICE_endocrine.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Dodecyltrimethylammonium chloride
Also known as: 1-Dodecanaminium, N,N,N-trimethyl-, chloride (Dodecyl trimethyl ammonium chloride), Arquad 12/50, EINECS 203-927-0, NSC 6931, Dodecyl trimethyl ammonium chloride (+1 more)
CAS 112-00-5
Dodecyltrimethylammonium chloride (CAS 112-00-5) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Dodecyltrimethylammonium chloride is classified GHS Danger (H302, H314, H315, H318, H319, H335, H400, H410) in the chemicals database but is restricted in EU cosmetics at max 0.1%.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
14
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
Dodecyltrimethylammonium chloride
CAS Number
112-00-5
DTXSID
DTXSID1026900
Molecular Formula
C15H34N.ClH
InChI Key
DDXLVDQZPFLQMZ-UHFFFAOYSA-M
Monoisotopic Mass
264.245803
Synonyms
1-Dodecanaminium, N,N,N-trimethyl-, chloride (Dodecyl trimethyl ammonium chloride)Arquad 12/50EINECS 203-927-0NSC 6931Dodecyl trimethyl ammonium chlorideUNII-A81MSI0FIC
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
32 records
Surfactant (surface active agent)Anti-static agentPreservativeEmulsifierSoftener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 14 of 14 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 17.7607465893395 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 9.45635249707941 | uM | ACC | - | - | NTP_ICE_endocrine |
| 16.2 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| A81MSI0FIC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A81MSI0FIC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A81MSI0FIC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A81MSI0FIC | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.0364 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| =300 | mg/kg bw/day | LOEL | oral | Mouse | ToxValDB_ECOTOX |
| =400 | mg/kg bw/day | LOEL | oral | Mouse | ToxValDB_ECOTOX |
| =500 | mg/kg bw/day | LOEL | oral | Mouse | ToxValDB_ECOTOX |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.261 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =200 | mg/kg bw/day | NOEL | oral | Mouse | ToxValDB_ECOTOX |
Showing 14 of 14 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dodecyltrimethylammonium chloride | 203-927-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.1%
Category
Preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1884887
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include Dodecyltrimethylammonium chloride?
Dodecyltrimethylammonium chloride appears on 2 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, children; Europe; Personal care. Source: EPA CPDat.
Is Dodecyltrimethylammonium chloride used in cosmetics?
Yes, Dodecyltrimethylammonium chloride is also indexed as a cosmetic ingredient under the name Laurtrimonium Chloride. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dodecyltrimethylammonium chloride come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Dodecyltrimethylammonium chloride have different safety status in cosmetics vs industrial chemicals?
Dodecyltrimethylammonium chloride is classified GHS Danger (H302, H314, H315, H318, H319, H335, H400, H410) in the chemicals database but is restricted in EU cosmetics at max 0.1%.
Is Dodecyltrimethylammonium chloride used outside industrial chemicals?
Dodecyltrimethylammonium chloride also appears in cosmetics, pharmaceutical databases.