What is the NOAEL for 1-Octanol?
1-Octanol has 28 NOAEL studies in the database. The lowest reported value is 41 unitless via Ocular in Rabbit. Source: NTP_ICE_eye_irritation.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1-Octanol
Also known as: 1-Hydroxyoctane, n-Caprylic alcohol, Caswell No. 611A, EINECS 203-917-6, EPA Pesticide Chemical Code 079037 (+15 more)
CAS 111-87-5
1-Octanol (CAS 111-87-5) is a chemical substance. Key regulatory status: REACH registered, 12 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Cross-Vertical Regulatory Divergence
1-Octanol is classified GHS Danger (H302, H312, H315, H319, H412, H227, H370, H371) in the chemicals database but is restricted in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
28
SOURCE
chemical inventory jurisdictions
Regulatory lists
12
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
1-Octanol
CAS Number
111-87-5
DTXSID
DTXSID7021940
Molecular Formula
C8H18O
InChI Key
KBPLFHHGFOOTCA-UHFFFAOYSA-N
Monoisotopic Mass
130.135765
Synonyms
1-Hydroxyoctanen-Caprylic alcoholCaswell No. 611AEINECS 203-917-6EPA Pesticide Chemical Code 079037Fatty alcohol(C8)FEMA No. 2800FEMA Number 2800Octyl alcohol, normal-primaryOctyl alcohol, primaryUNII-NV1779205D1-Oktanol
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes and respiratory tract. The substance is mildly irritating to the skin. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
28 records
Surfactant (surface active agent)DeodorizerFragranceViscosity modifierFlavouring and nutrientPlasticizerLubricating agentSolvent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
12 records
| List | Keyword | Source |
|---|---|---|
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Canada; pharmaceutical | DrugBank | DrugBank |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Europe | European Commission | Fl@vis |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 28 of 28 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =106 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =176 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 41 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| NV1779205D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| NV1779205D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| NV1779205D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| NV1779205D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.647 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| 2 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1296 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 0.16 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| >3200 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =130 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 10 | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| >400 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =130 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| ~210 | mg/kg bw/day | NOAEL | injection | Mouse | ToxValDB_ECHA_IUCLID |
| 650 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =1300 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 2564 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =10 | mmol/kg | NOEL | oral | Rat | ToxValDB_ECOTOX |
| 29 | % | Plateau level | Ocular | - | NTP_ICE_eye_irritation |
| 16.4 | % | Positive reaction | Dermal | Human | NTP_ICE_skin_irritation |
| 17.9 | % | Positive reaction | Dermal | Human | NTP_ICE_skin_irritation |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 28 of 28 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Octan-1-ol | 203-917-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
OCTANOL
ChEMBL Phase
2
Adverse Events
0
Bioactivity
2
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 1-Octanol?
1-Octanol appears on 10 regulatory/inventory lists including air; detected; emissions; Europe; Toys and children's products, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 7 more. Source: EPA CPDat.
Is 1-Octanol used in cosmetics?
Yes, 1-Octanol is also indexed as a cosmetic ingredient under the name Caprylyl Alcohol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1-Octanol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 1-Octanol have different safety status in cosmetics vs industrial chemicals?
1-Octanol is classified GHS Danger (H302, H312, H315, H319, H412, H227, H370, H371) in the chemicals database but is restricted in EU cosmetics.
Is 1-Octanol used outside industrial chemicals?
1-Octanol also appears in cosmetics, pharmaceutical, cannabis databases.