What is the NOAEL for Nonane?
Nonane has 19 NOAEL studies in the database. The lowest reported value is 3.936 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Nonane
Also known as: EINECS 203-913-4, Nonyl hydride, UNII-T9W3VH6G10, CH3-[CH2]7-CH3, Nonan
CAS 111-84-2
Nonane (CAS 111-84-2) is a chemical substance. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
Cross-Vertical Regulatory Divergence
Nonane is classified GHS Danger (H226, H304, H315, H319, H332, H336, H400, H410) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
19
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
Nonane
CAS Number
111-84-2
DTXSID
DTXSID9025796
Molecular Formula
C9H20
InChI Key
BKIMMITUMNQMOS-UHFFFAOYSA-N
Monoisotopic Mass
128.156501
Synonyms
EINECS 203-913-4Nonyl hydrideUNII-T9W3VH6G10CH3-[CH2]7-CH3Nonan
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Flammable liquid and vapour Harmful if inhaled May cause drowsiness or dizziness May be fatal if swallowed and enters airways May cause long lasting harmful effects to aquatic life |
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. Exposure to the vapour could cause lowering of consciousness. If swallowed the substance easily enters the airways and could result in aspiration pneumonitis. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour and by ingestion. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
3 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| NIOSH | TWA | 200 ppm (1050 mg/m³) | 200 | 1050 | N |
| ACGIH | TWA | 200 ppm [2011] | 200 | - | N |
| CAL/OSHA | TWA | 200 ppm (1050 mg/m³) | 200 | 1050 | N |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
FragranceSolvent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| detected; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 19 of 19 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 3.936 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| 3.936 | uL/min/10^6 cells | Clint | - | Rat | NTP_ICE_adme_parameters |
| =2035 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| T9W3VH6G10 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| T9W3VH6G10 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| T9W3VH6G10 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| T9W3VH6G10 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.08128 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| 0.1523 | fraction | Fu | - | Rat | NTP_ICE_adme_parameters |
| 16.776 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 17 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =100 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HESS |
| =3095.02 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_TX_TCEQ |
| =66.4 | mg/m3 | NOAEL (HEC) | inhalation | Rat | ToxValDB_PPRTV_(CPHEA) |
| =0.02 | mg/m3 | RfC (provisional) | inhalation | Human | ToxValDB_PPRTV_(CPHEA) |
| =0.2 | mg/m3 | RfC (provisional) | inhalation | Human | ToxValDB_PPRTV_(CPHEA) |
| =0.0003 | mg/kg bw/day | RfD | oral | Human | ToxValDB_RSL |
| =0.003 | mg/kg bw/day | RfD (provisional) | oral | Human | ToxValDB_PPRTV_(CPHEA) |
Showing 19 of 19 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Nonane | 203-913-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
NONANE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Nonane?
Nonane appears on 7 regulatory/inventory lists including detected; Other direct contact consumer goods, consumer_product; detected; Europe, air; detected; emissions; Europe; Vehicle - car interior, and 4 more. Source: EPA CPDat.
What are the occupational exposure limits for Nonane?
Occupational exposure limits for Nonane are set by NIOSH, ACGIH, CAL/OSHA. 3 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Nonane used in cosmetics?
Yes, Nonane is also indexed as a cosmetic ingredient under the name NONANE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Nonane come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Nonane have different safety status in cosmetics vs industrial chemicals?
Nonane is classified GHS Danger (H226, H304, H315, H319, H332, H336, H400, H410) in the chemicals database but is allowed in EU cosmetics.
Is Nonane used outside industrial chemicals?
Nonane also appears in cosmetics, pharmaceutical, cannabis databases.