What is the NOAEL for N-(2-Hydroxyethyl)oleamide?
N-(2-Hydroxyethyl)oleamide has 4 NOAEL studies in the database. The lowest reported value is 1HI5J9N8E6 UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
N-(2-Hydroxyethyl)oleamide
Also known as: 9-Octadecenamide, N-(2-hydroxyethyl)-, (9Z)-, (9Z)-N-(2-Hydroxyethyl)octadec-9-enamide, N-Oleoylethanolamine, 9-Octadecenamide, N-(2-hydroxyethyl)-, (Z)-, EINECS 203-884-8 (+12 more)
CAS 111-58-0
N-(2-Hydroxyethyl)oleamide (CAS 111-58-0) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
N-(2-Hydroxyethyl)oleamide is classified GHS Danger (H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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NOAEL studies
NOAEL studies
4
SOURCE
Chemical inventory jurisdictions
Regulatory lists
0
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
23 fields
Name
N-(2-Hydroxyethyl)oleamide
CAS Number
111-58-0
DTXSID
DTXSID1044516
Molecular Formula
C20H39NO2
InChI Key
BOWVQLFMWHZBEF-KTKRTIGZSA-N
Monoisotopic Mass
325.29808
Synonyms
9-Octadecenamide, N-(2-hydroxyethyl)-, (9Z)-(9Z)-N-(2-Hydroxyethyl)octadec-9-enamideN-Oleoylethanolamine9-Octadecenamide, N-(2-hydroxyethyl)-, (Z)-EINECS 203-884-8UNII-1HI5J9N8E6N-(2-Hydroxyethyl)-9-octadecenamideN-(9Z-octadecenoyl) ethanolamineN-(9Z-octadecenoyl)-ethanolamineN-(cis-9-octadecenoyl) ethanolamineN-(hydroxyethyl)oleamideN-Oleoyl ethanolamine, Oleoyl monoethanolamide, Oleoylethanolamide
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
Anti-static agentViscosity modifierFoamant
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 1HI5J9N8E6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1HI5J9N8E6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1HI5J9N8E6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1HI5J9N8E6 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | N-(2-hydroxyethyl)oleamide | 203-884-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Surfactant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
OLEOYLETHANOLAMIDE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
7
Frequently Asked Questions
Is N-(2-Hydroxyethyl)oleamide used in cosmetics?
Yes, N-(2-Hydroxyethyl)oleamide is also indexed as a cosmetic ingredient under the name OLEAMIDE MEA. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for N-(2-Hydroxyethyl)oleamide come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does N-(2-Hydroxyethyl)oleamide have different safety status in cosmetics vs industrial chemicals?
N-(2-Hydroxyethyl)oleamide is classified GHS Danger (H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Is N-(2-Hydroxyethyl)oleamide used outside industrial chemicals?
N-(2-Hydroxyethyl)oleamide also appears in cosmetics, pharmaceutical databases.