What is the GHS hazard classification for Diethylene glycol?
Diethylene glycol (CAS 111-46-6) is classified under EU CLP Annex VI as Acute Tox. 4 * with signal word Warning. Hazard statements: H302. Source: EU CLP Annex VI (ECHA).
Warning
GHS07
NOAEL Data
REACH Registered
Cosmetic Ingredient
Diethylene glycol
Also known as: Ethanol, 2,2'-oxybis-, 2-Hydroxyethyl ether, 2,2'-0xydiethanol, 4-01-00-02390, Bis(beta-hydroxyethyl) ether (+10 more)
CAS 111-46-6
Diethylene glycol (CAS 111-46-6) is a chemical substance with GHS signal word Warning; key hazard signal: H302. Key regulatory status: REACH registered, 29 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
71
SOURCE
chemical inventory jurisdictions
Regulatory lists
29
SOURCE
eu clp annex vi
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
21 fields
Name
Diethylene glycol
CAS Number
111-46-6
DTXSID
DTXSID8020462
Molecular Formula
C4H10O3
InChI Key
MTHSVFCYNBDYFN-UHFFFAOYSA-N
Monoisotopic Mass
106.062994
Synonyms
Ethanol, 2,2'-oxybis-2-Hydroxyethyl ether2,2'-0xydiethanol4-01-00-02390Bis(beta-hydroxyethyl) etherBRN 0969209Caswell No. 338AEINECS 203-872-2EPA Pesticide Chemical Code 338200Ethanol, 2,2'-oxydi-Glycol etherGlycol ethyl ether
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 * | H302 | GHS07 | Warning |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Harmful if swallowed Causes damage to kidneys if swallowed May cause drowsiness and dizziness |
| Short-term Effects | The substance may cause effects on the kidneys. This may result in kidney impairment. Ingestion could cause effects on the central nervous system and liver. Ingestion could cause death. |
| Routes of Exposure | The substance can be absorbed into the body by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
EmulsifierSolventDeodorizerFragranceViscosity modifierBinderLubricating agentMonomersNo specific technical functionProcessing aids not otherwise specified
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
29 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care; restricted | European Commission | CosIng |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| artificial_saliva; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe | Danish Environmental Protection Agency | Danish EPA |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Arts and crafts/Office supplies - home office - pens and markers; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - home office - pens and markers; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| fracking; water | NY Department of Conservation | CPCat |
| Arts and crafts/Office supplies - fabric treatment and dye; Arts and crafts/Office supplies - home office - pens and markers; detected | Danish Environmental Protection Agency | Danish EPA |
| banned; Europe; Personal care | European Commission | CosIng |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 71 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 1.6 | mg/kg bw/day | - | dermal | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 10 | - | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 50 | mg/kg bw/day | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 200 | mg/kg/day | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| =0.5 | mg/kg bw/day | ADI (group) | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =0.5 | mg/kg bw/day | ADI (group) | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =60 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =44 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 61BR964293 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 61BR964293 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 61BR964293 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 61BR964293 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.97 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| =12565 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =12570 | mg/kg bw | LD50 | oral | Rat (Female) | NTP_ICE_acute_oral |
| =15600 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =15650 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =16547 | mg/kg bw | LD50 | oral | Rat (Male/Female) | NTP_ICE_acute_oral |
| =16600 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =20760 | mg/kg bw | LD50 | oral | Rat (Male) | NTP_ICE_acute_oral |
| =28733 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =30186 | mg/kg bw | LD50 | oral | Rat (Male) | NTP_ICE_acute_oral |
| =69445.6 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| 100 | mg/kg bw/day | LOAEL | oral | rat | COSMOS_DB |
| 2795 | mg/kg bw/day | LOEL | Oral | Mouse | NTP_ICE_dart |
| 4472 | mg/kg bw/day | LOEL | Oral | Rat | NTP_ICE_dart |
| 4472 | mg/kg bw/day | LOEL | Oral | Rat | NTP_ICE_dart |
| 4472 | mg/kg bw/day | LOEL | Oral | Rat | NTP_ICE_dart |
| 11180 | mg/kg bw/day | LOEL | Oral | Mouse | NTP_ICE_dart |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =1.6 | mg/kg bw/day | NOAEL | dermal | - | SCCS_vision_codex |
| =1.6 | mg/kg bw/day | NOAEL | dermal | - | SCCS_vision_codex |
| =1.6 | mg/kg bw/day | NOAEL | dermal | - | SCCS_vision_codex |
| =1.6 | mg/kg bw/day | NOAEL | dermal | - | SCCS_vision_codex |
| =10 | - | NOAEL | - | rat | SCCS_vision_codex |
| =10 | - | NOAEL | - | rat | SCCS_vision_codex |
| =10 | - | NOAEL | - | rat | SCCS_vision_codex |
| =10 | - | NOAEL | - | rat | SCCS_vision_codex |
| 50 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =50 | mg/kg bw/day | NOAEL | oral | rat | SCCS_vision_codex |
| =50 | mg/kg bw/day | NOAEL | oral | rat | SCCS_vision_codex |
| =50 | mg/kg bw/day | NOAEL | oral | rat | SCCS_vision_codex |
| =50 | mg/kg bw/day | NOAEL | oral | rat | SCCS_vision_codex |
| =200 | mg/kg/day | NOAEL | - | rat | SCCS_vision_codex |
| =200 | mg/kg bw/day | NOAEL | - | rat | SCCS_vision_codex |
| =200 | mg/kg/day | NOAEL | - | rat | SCCS_vision_codex |
| =200 | mg/kg bw/day | NOAEL | - | rat | SCCS_vision_codex |
| =200 | mg/kg/day | NOAEL | - | rat | SCCS_vision_codex |
| =200 | mg/kg bw/day | NOAEL | - | rat | SCCS_vision_codex |
| =200 | mg/kg/day | NOAEL | - | rat | SCCS_vision_codex |
Showing 50 of 71 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,2'-oxydiethanol | 203-872-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCP/1156/08 | 24 June 2008 | not safe | Not safe as cosmetic ingredient | Renal toxicity; metabolised to toxic oxalic acid; not suitable for use in cosmetics |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
Subject to Annex III concentration and purity conditions
Category
Solvents
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
DI(HYDROXYETHYL)ETHER
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Diethylene glycol?
Diethylene glycol has 71 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.
What regulatory lists include Diethylene glycol?
Diethylene glycol appears on 14 regulatory/inventory lists including Europe; Personal care; restricted, detected; Europe; Toys and children's products, artificial_saliva; detected; emissions; Europe; Toys and children's products, and 11 more. Source: EPA CPDat.
Is Diethylene glycol used in cosmetics?
Yes, Diethylene glycol is also indexed as a cosmetic ingredient under the name Diethylene Glycol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Diethylene glycol come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Diethylene glycol used outside industrial chemicals?
Diethylene glycol also appears in cosmetics, pharmaceutical, cannabis databases.