Danger GHS06GHS05GHS08GHS09 NOAEL Data SVHC REACH Registered Cosmetic Ingredient

Glutaraldehyde

Also known as: Glutaric dialdehyde, Pentanedial, 4-01-00-03659, Aldesen, Alhydex (+12 more)

CAS 111-30-8

Glutaraldehyde (CAS 111-30-8) is a chemical substance with GHS signal word Danger; key hazard signal: H330; H301; H335; H314; H334; H317; H400; H411. Key regulatory status: SVHC Candidate List, REACH registered, 44 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ECHA SVHC, ILO ICSC, OSHA.

View cosmetic safety profile for Glutaral →

Cross-Vertical Regulatory Divergence

Glutaraldehyde is classified GHS Danger (H330, H301, H335, H314, H334, H317, H400, H411) in the chemicals database but is restricted in EU cosmetics at max 0.1%.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

100

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 23 fields

Name

Glutaraldehyde

CAS Number

111-30-8

DTXSID

DTXSID6025355

Molecular Formula

C5H8O2

InChI Key

SXRSQZLOMIGNAQ-UHFFFAOYSA-N

Monoisotopic Mass

100.052429

Synonyms

Glutaric dialdehydePentanedial4-01-00-03659AldesenAlhydexBRN 0605390Caswell No. 4681,3-DiformylpropaneEINECS 203-856-5EPA Pesticide Chemical Code 043901Glutaric aldehydeGlutarol

Substance of Very High Concern (SVHC)

Candidate List status and reason under the ECHA REACH SVHC program.

SOURCE ECHA 1 records

Substance	Reason	Included
glutaral	Respiratory sensitising properties (Article 57(f) - human health)	08-Jul-2021

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Acute Tox. 2; Acute Tox. 3; STOT SE 3; Skin Corr. 1B; Resp. Sens. 1; Skin Sens. 1A; Aquatic Acute 1; Aquatic Chronic 2	H330; H301; H335; H314; H334; H317; H400; H411	GHS06; GHS05; GHS08; GHS09	Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE WHO/JECFA 2 records

Field	Value
GHS Signal Word	DANGER
GHS Hazard Statements	Toxic if swallowed, in contact with skin or if inhaled Causes skin and eye irritation May cause an allergic skin reaction May cause allergy or asthma symptoms or breathing difficulties if inhaled May cause respiratory irritation Very toxic to aquatic life
Short-term Effects	The substance is irritating to the eyes, skin and respiratory tract.
Long-term Effects	Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. See Notes.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 6 records

Agency	Metric	Value	ppm	mg/m3	Skin
NIOSH	CEILING	0.2 ppm (0.8 mg/m³)	0.2	0.8	Y
ACGIH	CEILING	0.05 ppm [1998]	0.05	-	Y
CAL/OSHA	CEILING	0.05 ppm (0.2 mg/m³)	0.05	0.2	N
AIHA	ERPG-1	0.2 ppm	0.2	-	-
AIHA	ERPG-2	1 ppm	1	-	-
AIHA	ERPG-3	5 ppm	5	-	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

PreservativeBiocideFragranceFlavouring and nutrientProcessing aids not otherwise specifiedOxidizing agent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 44 records

List	Keyword	Source
pharmaceutical	US International Trade Commission	CPCat
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
Europe; Other direct contact consumer goods; residue	Danish Environmental Protection Agency	Danish EPA
Canada; pharmaceutical	DrugBank	DrugBank
Cleaning products and household care - dishwasher and dishes - automatic dishwashing detergent; Europe	Danish EPA	Danish EPA
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	State of California	State of California
active_ingredient; Pesticides	California Department of Pesticide Regulation	State of California
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; animal_products; Europe; pharmaceutical; residue	EU	CPCat
Europe	European Commission	Fl@vis
fracking	FracFocus	FracFocus
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies

Value	Unit	Endpoint	Route	Species	Source
1.32366462832733	uM	AC50	-	-	NTP ICE endocrine
0.849729331848536	uM	ACC	-	-	NTP ICE endocrine
=0.0839431	mg/m3	BMC (05)	inhalation	Mouse	ToxValDB Cal OEHHA REL derivations
=0.000327583	mg/m3	BMCL (10 HEC)	inhalation	Mouse	ToxValDB ATSDR MRLs
=0.0139223	mg/m3	BMCL (10)	inhalation	Mouse	ToxValDB ATSDR MRLs
2.7	ug/mL	CD54, EC200	Dermal	-	NTP ICE skin sensitization
0.2	ug/mL	CD86, EC150	Dermal	-	NTP ICE skin sensitization
2.78	ug/mL	CD86, EC150	Dermal	-	NTP ICE skin sensitization
83	ug/mL	CD86, EC150	Dermal	-	NTP ICE skin sensitization
>200	ug/mL	CV70	Dermal	-	NTP ICE skin sensitization
5.3	ug/mL	CV75	Dermal	-	NTP ICE skin sensitization
1.071	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP ICE skin sensitization
0.7143	%	Concentration, one positive response	Dermal	Human	NTP ICE skin sensitization
25.2	%	Depletion Cys	Dermal	-	NTP ICE skin sensitization
30.2	%	Depletion Cys	Dermal	-	NTP ICE skin sensitization
84.2	%	Depletion Lys	Dermal	-	NTP ICE skin sensitization
85.4	%	Depletion Lys	Dermal	-	NTP ICE skin sensitization
55	%	Depletion Lys + Cys	Dermal	-	NTP ICE skin sensitization
57.8	%	Depletion Lys + Cys	Dermal	-	NTP ICE skin sensitization
24.259	uM	EC1.5	Dermal	-	NTP ICE skin sensitization
<45.05	uM	EC1.5	Dermal	-	NTP ICE skin sensitization
0.04	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
0.04	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
0.04	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
0.04	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
0.07	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
0.07	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
0.07	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
0.07	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
0.09	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
0.09	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
0.09	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
0.09	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
0.1	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
0.1	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
0.1	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
0.1	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
2.1	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
2.1	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
2.1	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
2.1	%	EC3	Dermal	Mouse	NTP ICE skin sensitization
69.43	uM	EC3	Dermal	-	NTP ICE skin sensitization
1	unitless	EPA Classification	Ocular	Rabbit	NTP ICE eye irritation
3	unitless	EPA Classification	Inhalation	-	NTP ICE acute inhalation
=2	Unitless	EPA classification	oral	Rat	NTP ICE acute oral
3	unitless	EPA classification	Dermal	Rat	NTP ICE acute dermal
=3	Unitless	EPA classification	oral	Rat (Female)	NTP ICE acute oral
3	unitless	EPA classification	Dermal	Rabbit	NTP ICE skin irritation
T3C89M417N	UNII	FDA UNII substance identifier	-	-	openFDA substances
T3C89M417N	UNII	FDA UNII substance identifier	-	-	openFDA substances

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	Glutaral	203-856-5	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed_with_terms

Conditions

Specific information requirements: Obligations to provide information apply. These obligations are: 1. If the assessment report about the chemical recommends secondary notification of the chemical in particular circumstances and any of the circumstances occur in relation to the introduction (importation or manufacture) of the chemical by a person, then the person introducing this chemical must tell us in writing within 28 calendar days that the circumstances have occurred. 2. A person who introduces this chemical must tell us in writing within 28 calendar days if they become aware of any of the following circumstances, namely, that since the assessment under the Industrial Chemicals (Notification and Assessment) Act 1989: a. the function or use of the chemical has changed, or is likely to change, significantly; b. the amount of the chemical being introduced has increased, or is likely to increase, significantly; c. in the case of a chemical not manufactured, or proposed to be manufactured, in Australia at the time of the assessment—it has begun to be manufactured in Australia; d. the method of manufacture of the chemical in Australia has changed, or is likely to change, in a way that may result in an increased risk of an adverse effect of the chemical on occupational health and safety, public health or the environment; e. additional information has become available to the person as to an adverse effect of the chemical on occupational health and safety, public health or the environment.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

0.1%

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed GLUTARAL

ChEMBL Phase

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA 1 records

1 food-safety record found.

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Glutaraldehyde?

Glutaraldehyde (CAS 111-30-8) is classified under EU CLP Annex VI as Acute Tox. 2; Acute Tox. 3; STOT SE 3; Skin Corr. 1B; Resp. Sens. 1; Skin Sens. 1A; Aquatic Acute 1; Aquatic Chronic 2 with signal word Danger. Hazard statements: H330; H301; H335; H314; H334; H317; H400; H411. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Glutaraldehyde?

Glutaraldehyde has 100 NOAEL studies in the database. The lowest reported value is 0.000327583 mg/m3 via inhalation in Mouse. Source: ToxValDB ATSDR MRLs.

What regulatory lists include Glutaraldehyde?

Glutaraldehyde appears on 14 regulatory/inventory lists including pharmaceutical, active_ingredient; Europe; Pesticides, Europe; Other direct contact consumer goods; residue, and 11 more. Source: EPA CPDat.

Is Glutaraldehyde a Substance of Very High Concern (SVHC)?

Yes, Glutaraldehyde is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: Respiratory sensitising properties (Article 57(f) - human health). Source: ECHA SVHC Candidate List.

What are the occupational exposure limits for Glutaraldehyde?

Occupational exposure limits for Glutaraldehyde are set by NIOSH, ACGIH, CAL/OSHA. 6 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Glutaraldehyde used in cosmetics?

Yes, Glutaraldehyde is also indexed as a cosmetic ingredient under the name Glutaral. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Glutaraldehyde come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ECHA SVHC Candidate List, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Glutaraldehyde have different safety status in cosmetics vs industrial chemicals?

Glutaraldehyde is classified GHS Danger (H330, H301, H335, H314, H334, H317, H400, H411) in the chemicals database but is restricted in EU cosmetics at max 0.1%.

Is Glutaraldehyde used outside industrial chemicals?

Glutaraldehyde also appears in cosmetics, pharmaceutical, food safety, cannabis databases.