Warning GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

1-Hexanol

Also known as: hexyl alcohol, 4-01-00-01694, BRN 0969167, Caswell No. 482E, EINECS 203-852-3 (+15 more)

CAS 111-27-3

1-Hexanol (CAS 111-27-3) is a chemical substance with GHS signal word Warning; key hazard signal: H302. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Hexyl Alcohol →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

1-Hexanol

CAS Number

111-27-3

DTXSID

DTXSID8021931

Molecular Formula

C6H14O

InChI Key

ZSIAUFGUXNUGDI-UHFFFAOYSA-N

Monoisotopic Mass

102.104465

Synonyms

hexyl alcohol4-01-00-01694BRN 0969167Caswell No. 482EEINECS 203-852-3EPA Pesticide Chemical Code 079047FEMA No. 2567FEMA Number 2567UNII-6CP2QER8GSAlcohol(C6)BHLC6 alcohol

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Acute Tox. 4 *	H302	GHS07	Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	The substance is irritating to the respiratory tract and skin. The substance is severely irritating to the eyes. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis.
Long-term Effects	The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure	The substance can be absorbed into the body by inhalation and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 33 records

SolventSurfactant (surface active agent)Solubility enhancerFragranceDefoamerNo specific technical functionFlavouring and nutrientPlasticizer

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 7 records

List	Keyword	Source
inert_ingredient; Pesticides	EPA	CPCat
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
Europe	European Commission	Fl@vis
Australia; Food and drug - smoking-related products	New Zealand ESR	CPCat
IFRA Transparency	IFRA	IFRA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
consumer_product	P&G	Proctor & Gamble

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 58 studies

Value	Unit	Endpoint	Route	Species	Source
=210	mg/m3	DNEL local	inhalation	Human	ToxValDB_GESTIS_DNEL
=99	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
64.8	unitless	Draize rabbit irritation score	Ocular	Rabbit	NTP_ICE_eye_irritation
64.8	unitless	Draize rabbit irritation score	Ocular	Rabbit	NTP_ICE_eye_irritation
64.8	unitless	Draize rabbit irritation score	Ocular	Rabbit	NTP_ICE_eye_irritation
64.8	unitless	Draize rabbit irritation score	Ocular	Rabbit	NTP_ICE_eye_irritation
2	unitless	EPA Classification	Ocular	Rabbit	NTP_ICE_eye_irritation
2	unitless	EPA Classification	Ocular	Rabbit	NTP_ICE_eye_irritation
2	unitless	EPA Classification	Ocular	Rabbit	NTP_ICE_eye_irritation
2	unitless	EPA Classification	Ocular	Rabbit	NTP_ICE_eye_irritation
6CP2QER8GS	UNII	FDA UNII substance identifier	-	-	openFDA substances
6CP2QER8GS	UNII	FDA UNII substance identifier	-	-	openFDA substances
6CP2QER8GS	UNII	FDA UNII substance identifier	-	-	openFDA substances
6CP2QER8GS	UNII	FDA UNII substance identifier	-	-	openFDA substances
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
648	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
0.33	%/sec	Intensity	Ocular	-	NTP_ICE_eye_irritation
0.33	%/sec	Intensity	Ocular	-	NTP_ICE_eye_irritation
0.33	%/sec	Intensity	Ocular	-	NTP_ICE_eye_irritation
0.33	%/sec	Intensity	Ocular	-	NTP_ICE_eye_irritation
=720	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=3210	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=4420	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=4590	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=4870	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
>1500	mg/m3	LEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
=3000	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ECHA_IUCLID
=50148.5	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
=1	% diet	LOAEL	oral	Dog	ToxValDB_HPVIS
=1000	mg/kg bw/day	LOAEL	oral	Dog	ToxValDB_ECHA_IUCLID
-	s	Lag time	Ocular	-	NTP_ICE_eye_irritation
-	s	Lag time	Ocular	-	NTP_ICE_eye_irritation
-	s	Lag time	Ocular	-	NTP_ICE_eye_irritation
-	s	Lag time	Ocular	-	NTP_ICE_eye_irritation
-	unitless	Model Score	-	-	NTP_ICE_endocrine
=3500	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
>=158000	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
>0.5	% diet	NOAEL	oral	Dog	ToxValDB_HPVIS
=130	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=200	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
>370	mg/kg bw/day	NOAEL	oral	Dog	ToxValDB_ECHA_IUCLID
<435	mg/kg bw/day	NOAEL	oral	Dog	ToxValDB_ECHA_IUCLID
1000	mg/kg bw/day	NOAEL	oral	dog	COSMOS_DB
=1000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
1022	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
1127	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
=1127	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=1243	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
>3500	mg/m3	NOAEL	inhalation	Rat	ToxValDB_HPVIS
59	%	Plateau level	Ocular	-	NTP_ICE_eye_irritation

Showing 50 of 58 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Hexan-1-ol	203-852-3	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL 1-HEXANOL

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for 1-Hexanol?

1-Hexanol (CAS 111-27-3) is classified under EU CLP Annex VI as Acute Tox. 4 * with signal word Warning. Hazard statements: H302. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 1-Hexanol?

1-Hexanol has 58 NOAEL studies in the database. The lowest reported value is 0 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.

What regulatory lists include 1-Hexanol?

1-Hexanol appears on 7 regulatory/inventory lists including inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, Europe, and 4 more. Source: EPA CPDat.

Is 1-Hexanol used in cosmetics?

Yes, 1-Hexanol is also indexed as a cosmetic ingredient under the name Hexyl Alcohol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1-Hexanol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is 1-Hexanol used outside industrial chemicals?

1-Hexanol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.