What is the NOAEL for 2-Octanone?
2-Octanone has 13 NOAEL studies in the database. The lowest reported value is 1580 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Octanone
Also known as: 2-Oxooctane, Hexyl methyl ketone, Methyl hexyl ketone, 4-01-00-03339, BRN 0635843 (+5 more)
CAS 111-13-7
2-Octanone (CAS 111-13-7) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
13
SOURCE
chemical inventory jurisdictions
Regulatory lists
7
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
2-Octanone
CAS Number
111-13-7
DTXSID
DTXSID4021927
Molecular Formula
C8H16O
InChI Key
ZPVFWPFBNIEHGJ-UHFFFAOYSA-N
Monoisotopic Mass
128.120115
Synonyms
2-OxooctaneHexyl methyl ketoneMethyl hexyl ketone4-01-00-03339BRN 0635843EINECS 203-837-1FEMA No. 2802FEMA Number 2802UNII-J2G84H29AFFEMA 2802
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
40 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| artificial_sweat; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| artificial_sweat; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
| Europe | European Commission | Fl@vis |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1580 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =21100 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| J2G84H29AF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| J2G84H29AF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| J2G84H29AF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| J2G84H29AF | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2592 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >11.1732 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =9 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =3089 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Octan-2-one | 203-837-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL18549
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2-Octanone?
2-Octanone appears on 6 regulatory/inventory lists including air; detected; emissions; Europe; Toys and children's products, artificial_sweat; detected; emissions; Europe; Toys and children's products, IFRA Transparency, and 3 more. Source: EPA CPDat.
Is 2-Octanone used in cosmetics?
Yes, 2-Octanone is also indexed as a cosmetic ingredient under the name Hexyl Methyl Ketone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Octanone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 2-Octanone used outside industrial chemicals?
2-Octanone also appears in cosmetics, pharmaceutical, food safety, cannabis databases.