What is the NOAEL for Squalane?
Squalane has 7 NOAEL studies in the database. The lowest reported value is GW89575KF9 UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Squalane
Also known as: 4-01-00-00593, BRN 0776019, Caswell No. 482A, EINECS 203-825-6, EPA Pesticide Chemical Code 045503 (+3 more)
CAS 111-01-3
Squalane (CAS 111-01-3) is a chemical substance. Key regulatory status: REACH registered, 11 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
11
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
Squalane
CAS Number
111-01-3
DTXSID
DTXSID0046513
Molecular Formula
C30H62
InChI Key
PRAKJMSDJKAYCZ-UHFFFAOYSA-N
Monoisotopic Mass
422.485152
Synonyms
4-01-00-00593BRN 0776019Caswell No. 482AEINECS 203-825-6EPA Pesticide Chemical Code 045503Hexamethyl tetracosaneHexamethyltetracosaneUNII-GW89575KF9
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
31 records
Softener and conditionerBiocideHumectant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
11 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| GW89575KF9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GW89575KF9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GW89575KF9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GW89575KF9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >1000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| ~10000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| ~1000 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,6,10,15,19,23-hexamethyltetracosane | 203-825-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
emollient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
SQUALANE
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include Squalane?
Squalane appears on 6 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, children; Europe; Personal care, children; Europe; Personal care - general moisturizing - hand/body lotion, and 3 more. Source: EPA CPDat.
Is Squalane used in cosmetics?
Yes, Squalane is also indexed as a cosmetic ingredient under the name Squalane. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Squalane come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Squalane used outside industrial chemicals?
Squalane also appears in cosmetics, pharmaceutical databases.