NOAEL Data Cosmetic Ingredient

5-Amino-4-chloro-o-cresol hydrochloride

Also known as: 2-Methyl-4-chloro-5-aminophenol hydrochloride, Phenol, 5-amino-4-chloro-2-methyl-, hydrochloride (1:1), UNII-31J4UQW59L

CAS 110102-85-7

5-Amino-4-chloro-o-cresol hydrochloride (CAS 110102-85-7) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, SCCS.

View cosmetic safety profile for 5-Amino-4-Chloro-o-Cresol HCl →

SOURCE noael studies public
NOAEL studies
36
SOURCE chemical inventory jurisdictions
Regulatory lists
1
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 9 fields
Name
5-Amino-4-chloro-o-cresol hydrochloride
CAS Number
110102-85-7
DTXSID
DTXSID001021269
Molecular Formula
C7H8ClNO.ClH
InChI Key
KPBXDJZVHWRFLV-UHFFFAOYSA-N
Monoisotopic Mass
193.006119
Synonyms
2-Methyl-4-chloro-5-aminophenol hydrochloridePhenol, 5-amino-4-chloro-2-methyl-, hydrochloride (1:1)UNII-31J4UQW59L

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records
ListKeywordSource
Europe; Personal care; restrictedEuropean CommissionCosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 36 of 36 studies
ValueUnitEndpointRouteSpeciesSource
31J4UQW59LUNIIFDA UNII substance identifier--openFDA substances
31J4UQW59LUNIIFDA UNII substance identifier--openFDA substances
31J4UQW59LUNIIFDA UNII substance identifier--openFDA substances
31J4UQW59LUNIIFDA UNII substance identifier--openFDA substances
=0.19mg/kgNOAELoralratSCCS_vision_codex
=0.19mg/kgNOAELoralratSCCS_vision_codex
=0.19mg/kgNOAELoralratSCCS_vision_codex
=0.19mg/kgNOAELoralratSCCS_vision_codex
180mg/kg bw/dayNOAELoralratCOSMOS_DB
=180mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=180mg/kg bwNOAELoralratSCCS_vision_codex
=180mg/kg bw/dayNOAELdermalrabbitSCCNFP_vision_codex
=180mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=180mg/kg bwNOAELoralratSCCS_vision_codex
=180mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=180mg/kg bwNOAELoralratSCCS_vision_codex
=180mg/kg bw/dayNOAELdermalrabbitSCCNFP_vision_codex
=180mg/kg bw/dayNOAELdermalrabbitSCCNFP_vision_codex
=180mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=180mg/kg bwNOAELoralratSCCS_vision_codex
=180mg/kg bw/dayNOAELdermalrabbitSCCNFP_vision_codex
=500mg/kg bw/dayNOAELoralhumanSCCS_vision_codex
=500mg/kg bw/dayNOAELoralhumanSCCS_vision_codex
=500mg/kg bw/dayNOAELoralhumanSCCS_vision_codex
=500mg/kg bw/dayNOAELoralhumanSCCS_vision_codex
=0.19mg/kgdermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=180mg/kg bwdermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=180mg/kg bwdermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
500mg/kg bw/daydevelopmental toxicityoralhumanUnifiedCodex:SCCS_SHADOW:beta.noael_studies
180mg/kg bw/daygenotoxicity-ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
180mg/kg bw/daygenotoxicity-ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
180mg/kg bw/dayirritation-ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
180mg/kg bw/dayirritation-ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
180mg/kg bw/dayirritation-ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
180mg/kg bw/dayrepeated dose toxicitydermalrabbitUnifiedCodex:SCCNFP:beta.noael_studies
180mg/kg bw/dayrepeated dose toxicity-ratUnifiedCodex:SCCNFP:beta.noael_studies

Showing 36 of 36 studies

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 3 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1483/1211 December 2012safe with restrictions1.0% oxidative / 0.5% non-oxidativesensitisation potential cannot be excluded
SCCS/1387/108 December 2009safe with restrictions1.0% oxidative / 0.5% non-oxidativesensitisation not excluded; purity specifications required
SCCP/1111/0718 December 2007insufficient data-genotoxicity in vitro positive; further in vivo data required

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
1.5%
Category
Colorant
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for 5-Amino-4-chloro-o-cresol hydrochloride?

5-Amino-4-chloro-o-cresol hydrochloride has 36 NOAEL studies in the database. The lowest reported value is 31J4UQW59L UNII. Source: openFDA substances.

What regulatory lists include 5-Amino-4-chloro-o-cresol hydrochloride?

5-Amino-4-chloro-o-cresol hydrochloride appears on 1 regulatory/inventory list including Europe; Personal care; restricted. Source: EPA CPDat.

Is 5-Amino-4-chloro-o-cresol hydrochloride used in cosmetics?

Yes, 5-Amino-4-chloro-o-cresol hydrochloride is also indexed as a cosmetic ingredient under the name 5-Amino-4-Chloro-o-Cresol HCl. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 5-Amino-4-chloro-o-cresol hydrochloride come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is 5-Amino-4-chloro-o-cresol hydrochloride used outside industrial chemicals?

5-Amino-4-chloro-o-cresol hydrochloride also appears in cosmetics databases.