Also known as: 4-27-00-00015, BRN 0102549, Caswell No. 584, EINECS 203-815-1, EPA Pesticide Chemical Code 054701 (+2 more)
CAS 110-91-8
Morpholine (CAS 110-91-8) is a chemical substance with GHS signal word Danger; key hazard signal: H226; H332; H312; H302; H314. Key regulatory status: REACH registered, 14 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC, OSHA.
Morpholine is classified GHS Danger (H226, H332, H312, H302, H314) in the chemicals database but is restricted in EU cosmetics at max II/344.
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1998 | 47, 71 |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 3; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1B | H226; H332; H312; H302; H314 | GHS02; GHS07; GHS05 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. See Notes. |
| Long-term Effects | The substance may have effects on the liver and kidneys. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation, through the skin and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 20 ppm (70 mg/m³) | 20 | 70 | Y |
| NIOSH | TWA | 20 ppm (70 mg/m³) | 20 | 70 | Y |
| NIOSH | STEL | 30 ppm (105 mg/m³) | 30 | 105 | Y |
| ACGIH | TWA | 20 ppm [1992] | 20 | - | Y |
| CAL/OSHA | TWA | 20 ppm (70 mg/m³) | 20 | 70 | Y |
| CAL/OSHA | STEL | 30 ppm (105 mg/m³) | 30 | 105 | Y |
| NIOSH | IDLH | 1400 ppm | 1400 | - | - |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| banned; Europe; Personal care | European Commission | CosIng |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =36 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 8B2ZCK305O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8B2ZCK305O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8B2ZCK305O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8B2ZCK305O | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| 28.4884 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =1050 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >1420 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| <1440 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1450 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1600 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >1610 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| <1630 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1913 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =49886.1 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =36 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_EU_SCOEL |
| 50 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 90 | mg/kg bw/day | NOAEL | oral | guinea pig | COSMOS_DB |
| =90 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_EU_SCOEL |
| =90 | mg/m3 | NOAEL | - | Rat | INCHEM_WHO_ehc_ehc_ehc179 |
| =90 | mg/m3 | NOAEL | - | Rat | INCHEM_WHO_ehc_ehc_ehc179 |
| 120 | mg/kg bw/day | NOAEL | oral | hamster | COSMOS_DB |
| 160 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 6316 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
Showing 29 of 29 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Morpholine | 203-815-1 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS food additive, ADI, and GRAS records where available.
1 food-safety record found.
View full food safety profile →Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Morpholine (CAS 110-91-8) is classified under EU CLP Annex VI as Flam. Liq. 3; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1B with signal word Danger. Hazard statements: H226; H332; H312; H302; H314. Source: EU CLP Annex VI (ECHA).
Morpholine has 29 NOAEL studies in the database. The lowest reported value is 36 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
Morpholine appears on 6 regulatory/inventory lists including active_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, active_ingredient; Europe; Pesticides, and 3 more. Source: EPA CPDat.
Morpholine is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Occupational exposure limits for Morpholine are set by OSHA, NIOSH, ACGIH. 7 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Morpholine is also indexed as a cosmetic ingredient under the name MORPHOLINE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Morpholine is classified GHS Danger (H226, H332, H312, H302, H314) in the chemicals database but is restricted in EU cosmetics at max II/344.
Morpholine also appears in cosmetics, pharmaceutical, food safety, cannabis databases.