NOAEL Data REACH Registered Cosmetic Ingredient

1,4-Butanediol

Also known as: 4-01-00-02515, Agrisynth B1D, BRN 1633445, EINECS 203-786-5, UNII-7XOO2LE6G3 (+3 more)

CAS 110-63-4

1,4-Butanediol (CAS 110-63-4) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for 1,4-Butanediol →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 14 fields

Name

1,4-Butanediol

CAS Number

110-63-4

DTXSID

DTXSID2024666

Molecular Formula

C4H10O2

InChI Key

WERYXYBDKMZEQL-UHFFFAOYSA-N

Monoisotopic Mass

90.06808

Synonyms

4-01-00-02515Agrisynth B1DBRN 1633445EINECS 203-786-5UNII-7XOO2LE6G31,4-BDHO(CH2)4OHHOCH2CH2CH2CH2OH

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	The substance may cause effects on the central nervous system. This may result in narcosis.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 14 records

SolventBinderProcessing aids not otherwise specifiedPlasticizer

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 7 records

List	Keyword	Source
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
detected; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
detected; Toys and children's products	Journal of Medical Toxicology	Published Articles
Canada; pharmaceutical	DrugBank	DrugBank
CEDI	FDA	United States Food and Drug Administration (FDA)
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)
inert_ingredient; non_food_use; Pesticides	EPA	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 22 of 22 studies

Value	Unit	Endpoint	Route	Species	Source
>=0.1	mg/kg bw/day	ADI	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
>=0.1	mg/kg bw/day	ADI	-	Consumers	EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx
=136	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
7XOO2LE6G3	UNII	FDA UNII substance identifier	-	-	openFDA substances
7XOO2LE6G3	UNII	FDA UNII substance identifier	-	-	openFDA substances
7XOO2LE6G3	UNII	FDA UNII substance identifier	-	-	openFDA substances
7XOO2LE6G3	UNII	FDA UNII substance identifier	-	-	openFDA substances
>5.1	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
>15	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=4600	mg/m3	LEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
=71876.8	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
=500	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=5000	mg/m3	LOEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=5200	mg/m3	LOEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
-	unitless	Model Score	-	-	NTP_ICE_endocrine
=50	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=400	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=800	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=1000	mg/m3	NOEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=1100	mg/m3	NOEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
<200	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID
=400	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID

Showing 22 of 22 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Butane-1,4-diol	203-786-5	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL 1,4-BUTANEDIOL

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for 1,4-Butanediol?

1,4-Butanediol has 22 NOAEL studies in the database. The lowest reported value is 0.1 mg/kg bw/day in Consumers. Source: EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx.

What regulatory lists include 1,4-Butanediol?

1,4-Butanediol appears on 6 regulatory/inventory lists including detected; Europe; Toys and children's products, detected; Toys and children's products, Canada; pharmaceutical, and 3 more. Source: EPA CPDat.

Is 1,4-Butanediol used in cosmetics?

Yes, 1,4-Butanediol is also indexed as a cosmetic ingredient under the name 1,4-Butanediol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1,4-Butanediol come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is 1,4-Butanediol used outside industrial chemicals?

1,4-Butanediol also appears in cosmetics, pharmaceutical, cannabis databases.