Also known as: Dipropyl, EINECS 203-777-6, Gettysolve-B, NCI-C60571, Hexanen (+3 more)
CAS 110-54-3
N-Hexane (CAS 110-54-3) is a chemical substance with GHS signal word Danger; key hazard signal: H225; H361f ***; H304; H336; H372 (nervous system); H315; H411. Key regulatory status: SVHC Candidate List, California Proposition 65, REACH registered, 18 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ECHA SVHC, CA Prop 65, ILO ICSC, OSHA, EPA TRI.
N-Hexane is prohibited in EU cosmetics but has active industrial GHS classifications (H225, H361f, H304, H336, H372, H315, H411).
CAS, identifiers, formula, and alternate names for the matched substance record.
Candidate List status and reason under the ECHA REACH SVHC program.
| Substance | Reason | Included |
|---|---|---|
| n-hexane | Specific target organ toxicity after repeated exposure (Article 57(f) - human health) | 04-Feb-2026 |
California OEHHA listing status and toxicity category.
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | male | No | No | - |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 2; Repr. 2; Asp. Tox. 1; STOT SE 3; STOT RE 1; Skin Irrit. 2; Aquatic Chronic 2 | H225; H361f ***; H304; H336; H372 (nervous system); H315; H411 | GHS02; GHS08; GHS07; GHS09 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Flammable liquid and vapour Causes skin irritation May cause drowsiness or dizziness Causes damage to the nervous system through prolonged or repeated exposure May damage fertility or the unborn child if inhaled May be fatal if swallowed and enters airways Toxic to aquatic life with long lasting effects |
| Short-term Effects | The substance is irritating to the skin. The substance is mildly irritating to the eyes and respiratory tract. Exposure to high concentrations of vapour could cause unconsciousness. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. See Notes. |
| Long-term Effects | Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the central nervous system and peripheral nervous system. This may result in polyneuropathy. Animal tests show that this substance possibly causes toxic effects upon human reproduction. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 500 ppm (1800 mg/m³) | 500 | 1800 | N |
| NIOSH | TWA | 50 ppm (180 mg/m³) | 50 | 180 | N |
| ACGIH | TWA | 50 ppm [1996] | 50 | - | Y |
| CAL/OSHA | TWA | 50 ppm (176 mg/m³) | 50 | 176 | Y |
| NIOSH | IDLH | 1100 ppm | 1100 | - | - |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| air; Arts and crafts/Office supplies - home office - pens and markers; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Personal care | Elsevier | CPCat |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Home maintenance - caulk/sealant | Danish Environmental Protection Agency | Danish EPA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| banned; Europe; Personal care | European Commission | CosIng |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Cons electronics mech appliances and machinery; Europe | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; detected | Elsevier | CPCat |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| IFRA Transparency | IFRA | IFRA |
| Europe; Food contact items | Danish Environmental Protection Agency | Danish EPA |
| banned; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =550 | mg/m3 | BMC | inhalation | Rat | ToxValDB_IRIS |
| =430 | mg/m3 | BMCL | inhalation | Rat | ToxValDB_IRIS |
| =215 | mg/m3 | BMCL (ADJ) | inhalation | Rat | ToxValDB_IRIS |
| =215 | mg/m^3 | BMCL (HEC) | inhalation | - | EPA_IRIS_iris_rfc_systems.csv |
| >200 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| >603.246 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 62.5 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 1666.7 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| SQEinhalation=20000; oral=28000 | ug/day | California Proposition 65 MADL | - | - | California Proposition 65 |
| SQEinhalation=20000; oral=28000 | ug/day | California Proposition 65 MADL | - | - | California Proposition 65 |
| SQEinhalation=20000; oral=28000 | ug/day | California Proposition 65 MADL | - | - | California Proposition 65 |
| SQEinhalation=20000; oral=28000 | ug/day | California Proposition 65 MADL | - | - | California Proposition 65 |
| SQEmale | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEmale | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEmale | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEmale | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| 5.557 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| 30.13 | uL/min/10^6 cells | Clint | - | Rat | NTP_ICE_adme_parameters |
| =75 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| -0.9 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| -0.4 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| -5.1 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 2.6 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 0.85 | % | Depletion Lys + Cys | Dermal | - | NTP_ICE_skin_sensitization |
| - | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 562 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| >2000 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 1S70G88A39 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1S70G88A39 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1S70G88A39 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1S70G88A39 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2DDG612ED8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2DDG612ED8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2DDG612ED8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2DDG612ED8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.1931 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| 0.2909 | fraction | Fu | - | Rat | NTP_ICE_adme_parameters |
| >2000 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| >2400 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 1.14 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.226 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| 1.51 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 62070 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 0.01 | %/sec | Intensity | Ocular | - | NTP_ICE_eye_irritation |
| >17.6123 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >31.86 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 169.0786 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| 270.8779 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
Showing 50 of 82 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | n-hexane | 203-777-6 | ECHA overview → |
TRI hazard and reporting flags for the matched chemical.
| Chemical | Category | Flags |
|---|---|---|
| n-Hexane (Hexane) | - | - |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS food additive, ADI, and GRAS records where available.
1 food-safety record found.
View full food safety profile →Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →N-Hexane (CAS 110-54-3) is classified under EU CLP Annex VI as Flam. Liq. 2; Repr. 2; Asp. Tox. 1; STOT SE 3; STOT RE 1; Skin Irrit. 2; Aquatic Chronic 2 with signal word Danger. Hazard statements: H225; H361f ***; H304; H336; H372 (nervous system); H315; H411. Source: EU CLP Annex VI (ECHA).
N-Hexane has 82 NOAEL studies in the database. The lowest reported value is 62.5 ug/mL via Dermal. Source: NTP_ICE_skin_sensitization.
N-Hexane appears on 18 regulatory/inventory lists including air; Arts and crafts/Office supplies - home office - pens and markers; detected; emissions; Europe, air; detected; emissions; Personal care, air; detected; emissions; Europe; Vehicle - car interior, and 15 more. Source: EPA CPDat.
Yes, N-Hexane is listed under California Proposition 65 for male. Source: California OEHHA Proposition 65.
Yes, N-Hexane is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: Specific target organ toxicity after repeated exposure (Article 57(f) - human health). Source: ECHA SVHC Candidate List.
Occupational exposure limits for N-Hexane are set by OSHA, NIOSH, ACGIH. 5 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, N-Hexane is also indexed as a cosmetic ingredient under the name Hexane. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ECHA SVHC Candidate List, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
N-Hexane is prohibited in EU cosmetics but has active industrial GHS classifications (H225, H361f, H304, H336, H372, H315, H411).
N-Hexane also appears in cosmetics, pharmaceutical, food safety, cannabis databases.