Warning GHS02GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

2-Heptanone

Also known as: 1-Methylhexanal, 2-Oxoheptane, Amyl methyl ketone, Butylacetone, Methyl amyl ketone (+12 more)

CAS 110-43-0

2-Heptanone (CAS 110-43-0) is a chemical substance with GHS signal word Warning; key hazard signal: H226; H332; H302. Key regulatory status: REACH registered, 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.

View cosmetic safety profile for Methyl Amyl Ketone →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 23 fields

Name

2-Heptanone

CAS Number

110-43-0

DTXSID

DTXSID5021916

Molecular Formula

C7H14O

InChI Key

CATSNJVOTSVZJV-UHFFFAOYSA-N

Monoisotopic Mass

114.104465

Synonyms

1-Methylhexanal2-OxoheptaneAmyl methyl ketoneButylacetoneMethyl amyl ketoneMethyl n-amyl ketoneMethyl pentyl ketonePentyl methyl ketone4-01-00-03318BRN 1699063EINECS 203-767-1FEMA Number 2544

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Flam. Liq. 3; Acute Tox. 4 ; Acute Tox. 4	H226; H332; H302	GHS02; GHS07	Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause lowering of consciousness.
Long-term Effects	The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its vapour.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 5 records

Agency	Metric	Value	ppm	mg/m3	Skin
OSHA	TWA	100 ppm (465 mg/m³)	100	465	N
NIOSH	TWA	100 ppm (465 mg/m³)	100	465	N
ACGIH	TWA	50 ppm [1978]	50	-	N
CAL/OSHA	TWA	50 ppm (235 mg/m³)	50	235	N
NIOSH	IDLH	800 ppm	800	-	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 8 records

FragranceFlavouring and nutrientSolvent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 9 records

List	Keyword	Source
artificial_sweat; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
artificial_sweat; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
air; detected; emissions; Europe; Other direct contact consumer goods	Danish Environmental Protection Agency	Danish EPA
IFRA Transparency	IFRA	IFRA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
consumer_product	P&G	Proctor & Gamble
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
Europe	European Commission	Fl@vis

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 27 of 27 studies

Value	Unit	Endpoint	Route	Species	Source
=394.25	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
3	unitless	EPA Classification	Ocular	Rabbit	NTP_ICE_eye_irritation
89VVP1B008	UNII	FDA UNII substance identifier	-	-	openFDA substances
89VVP1B008	UNII	FDA UNII substance identifier	-	-	openFDA substances
89VVP1B008	UNII	FDA UNII substance identifier	-	-	openFDA substances
89VVP1B008	UNII	FDA UNII substance identifier	-	-	openFDA substances
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
2592	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
0.2	%/sec	Intensity	Ocular	-	NTP_ICE_eye_irritation
range9	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
>16.7	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=1670	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=18681.2	mg/m3	LEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
=51373.2	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
50	s	Lag time	Ocular	-	NTP_ICE_eye_irritation
-	unitless	Model Score	-	-	NTP_ICE_endocrine
=5604.35	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=20	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=20	mg/kg bw/day	NOAEL	oral: gavage	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=20	mg/kg bw/day	NOAEL	oral: gavage	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=32	ppm	NOAEL	vapor	Human	ToxValDB_TX_TCEQ
100	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
=1000	ppm	NOAEL	oral or inhalation	Rat	ToxValDB_EU_SCOEL
=4787.05	mg/m3	NOAEL	inhalation	Monkey	ToxValDB_TX_TCEQ
=4670.29	mg/m3	NOEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
9	%	Plateau level	Ocular	-	NTP_ICE_eye_irritation
3	unitless	Relative reliability score	Dermal	Human	NTP_ICE_skin_sensitization

Showing 27 of 27 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Heptan-2-one	203-767-1	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL18893

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for 2-Heptanone?

2-Heptanone (CAS 110-43-0) is classified under EU CLP Annex VI as Flam. Liq. 3; Acute Tox. 4 *; Acute Tox. 4 * with signal word Warning. Hazard statements: H226; H332; H302. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 2-Heptanone?

2-Heptanone has 27 NOAEL studies in the database. The lowest reported value is 3 unitless via Ocular in Rabbit. Source: NTP_ICE_eye_irritation.

What regulatory lists include 2-Heptanone?

2-Heptanone appears on 8 regulatory/inventory lists including artificial_sweat; detected; emissions; Europe; Toys and children's products, air; detected; emissions; Europe; Toys and children's products, air; detected; emissions; Europe; Other direct contact consumer goods, and 5 more. Source: EPA CPDat.

What are the occupational exposure limits for 2-Heptanone?

Occupational exposure limits for 2-Heptanone are set by OSHA, NIOSH, ACGIH. 5 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is 2-Heptanone used in cosmetics?

Yes, 2-Heptanone is also indexed as a cosmetic ingredient under the name Methyl Amyl Ketone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Heptanone come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is 2-Heptanone used outside industrial chemicals?

2-Heptanone also appears in cosmetics, pharmaceutical, cannabis databases.