What is the NOAEL for Oleyl sarcosine?
Oleyl sarcosine has 11 NOAEL studies in the database. The lowest reported value is 23.5363574220131 uM. Source: NTP ICE endocrine.
NOAEL Data
Cosmetic Ingredient
Oleyl sarcosine
Also known as: Glycine, N-methyl-N-[(9Z)-1-oxo-9-octadecen-1-yl]-, N-Methyl-N-oleoylglycine, EINECS 203-749-3, Hamposyl O, Maprosyl O (+9 more)
CAS 110-25-8
Oleyl sarcosine (CAS 110-25-8) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
Cross-Vertical Regulatory Divergence
Oleyl sarcosine is classified GHS Danger (H314, H319, H332, H315, H318, H400, H410, H412) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
11
SOURCE
Chemical inventory jurisdictions
Regulatory lists
3
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
20 fields
Name
Oleyl sarcosine
CAS Number
110-25-8
DTXSID
DTXSID5042243
Molecular Formula
C21H39NO3
InChI Key
DIOYAVUHUXAUPX-KHPPLWFESA-N
Monoisotopic Mass
353.292994
Synonyms
Glycine, N-methyl-N-[(9Z)-1-oxo-9-octadecen-1-yl]-N-Methyl-N-oleoylglycineEINECS 203-749-3Hamposyl OMaprosyl OMedialanic acidNSC 96995Oleic sarcosineOleoyl SarcosineOleoylsarcosineN-OleoylsarcosineSarkosyl O
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
Surfactant (surface active agent)Anti-static agentCleaning agentSoftener and conditionerWetting agent (non-aqueous)
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 25.4331779720626 | uM | AC50 | - | - | NTP ICE endocrine |
| 23.5363574220131 | uM | ACC | - | - | NTP ICE endocrine |
| 41.7 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| 4011K1S96Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4011K1S96Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4011K1S96Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4011K1S96Y | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3.54e-8 | fraction | Fu | - | Human | NTP ICE adme parameters |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| - | unitless | Model Score | - | - | NTP ICE endocrine |
| 0.018 | unitless | Model Score | - | - | NTP ICE endocrine |
Showing 11 of 11 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Surfactant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL3183932
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Oleyl sarcosine?
Oleyl sarcosine appears on 3 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, CEDI, Indirect additives food contact (10/2018). Source: EPA CPDat.
Is Oleyl sarcosine used in cosmetics?
Yes, Oleyl sarcosine is also indexed as a cosmetic ingredient under the name OLEOYL SARCOSINE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Oleyl sarcosine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Oleyl sarcosine have different safety status in cosmetics vs industrial chemicals?
Oleyl sarcosine is classified GHS Danger (H314, H319, H332, H315, H318, H400, H410, H412) in the chemicals database but is allowed in EU cosmetics.
Is Oleyl sarcosine used outside industrial chemicals?
Oleyl sarcosine also appears in cosmetics, pharmaceutical databases.