What is the NOAEL for Dimethoxymethane?
Dimethoxymethane has 8 NOAEL studies in the database. The lowest reported value is 126.6 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Dimethoxymethane
Also known as: Methylal, Methane, dimethoxy-, 2,4-Dioxapentane, Bis(methoxy)methane, Dimethoxy methane (+9 more)
CAS 109-87-5
Dimethoxymethane (CAS 109-87-5) is a chemical substance. Key regulatory status: REACH registered, 10 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
Cross-Vertical Regulatory Divergence
Dimethoxymethane is classified GHS Danger (H225, H315, H319, H335, H336) in the chemicals database but is restricted in EU cosmetics at max 0.1%.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
10
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
20 fields
Name
Dimethoxymethane
CAS Number
109-87-5
DTXSID
DTXSID1025564
Molecular Formula
C3H8O2
InChI Key
NKDDWNXOKDWJAK-UHFFFAOYSA-N
Monoisotopic Mass
76.052429
Synonyms
MethylalMethane, dimethoxy-2,4-DioxapentaneBis(methoxy)methaneDimethoxy methaneFORMALDEHYDE DIMETHYL ACETALMethane, dimethoxyUN 1234EINECS 203-714-2MetylalUNII-7H1M4G2NUEbis(methyloxy)methane
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Highly flammable liquid and vapour Causes eye irritation May cause drowsiness or dizziness |
| Short-term Effects | The substance is irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause unconsciousness. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
5 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 1000 ppm (3100 mg/m³) | 1000 | 3100 | N |
| NIOSH | TWA | 1000 ppm (3100 mg/m³) | 1000 | 3100 | N |
| ACGIH | TWA | 1000 ppm [1970] | 1000 | - | N |
| CAL/OSHA | TWA | 1000 ppm (3100 mg/m³) | 1000 | 3100 | N |
| NIOSH | IDLH | 2200 ppm | 2200 | - | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
SolventFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
10 records
| List | Keyword | Source |
|---|---|---|
| air; Arts and crafts/Office supplies - fabric treatment and dye; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| Europe; Pesticides | Danish EPA | Danish EPA |
| detected; Europe; Pesticides | Danish EPA | Danish EPA |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts adhesive; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe | European Commission | Fl@vis |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =126.6 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 7H1M4G2NUE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7H1M4G2NUE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7H1M4G2NUE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7H1M4G2NUE | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 46.655 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =6423 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =68470.3 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dimethoxymethane | 203-714-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.1%
Category
Solvent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
DIMETHOXYMETHANE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Dimethoxymethane?
Dimethoxymethane appears on 9 regulatory/inventory lists including air; Arts and crafts/Office supplies - fabric treatment and dye; detected; emissions; Europe, air; detected; emissions; Europe; Vehicle - car interior, detected; Europe; Vehicle - car interior, and 6 more. Source: EPA CPDat.
What are the occupational exposure limits for Dimethoxymethane?
Occupational exposure limits for Dimethoxymethane are set by OSHA, NIOSH, ACGIH. 5 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Dimethoxymethane used in cosmetics?
Yes, Dimethoxymethane is also indexed as a cosmetic ingredient under the name Methylal. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dimethoxymethane come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Dimethoxymethane have different safety status in cosmetics vs industrial chemicals?
Dimethoxymethane is classified GHS Danger (H225, H315, H319, H335, H336) in the chemicals database but is restricted in EU cosmetics at max 0.1%.
Is Dimethoxymethane used outside industrial chemicals?
Dimethoxymethane also appears in cosmetics, pharmaceutical, cannabis databases.