Also known as: Ethylene glycol monomethyl ether, UN 1188 (DOT), EGME, Methyl cellosolve, Hisolve MC (+15 more)
CAS 109-86-4
2-Methoxyethanol (CAS 109-86-4) is a chemical substance with GHS signal word Danger; key hazard signal: H226; H360FD; H332; H312; H302. Key regulatory status: SVHC Candidate List, California Proposition 65, REACH registered, 23 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ECHA SVHC, CA Prop 65, ILO ICSC, OSHA, EPA TRI.
2-Methoxyethanol is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H360FD, H332, H312, H302).
CAS, identifiers, formula, and alternate names for the matched substance record.
Candidate List status and reason under the ECHA REACH SVHC program.
| Substance | Reason | Included |
|---|---|---|
| 2-methoxyethanol | Toxic for reproduction (Article 57c) | 15-Dec-2010 |
California OEHHA listing status and toxicity category.
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | developmental, male | No | Yes | - |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 3; Repr. 1B; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 * | H226; H360FD; H332; H312; H302 | GHS02; GHS08; GHS07 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is mildly irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system, blood, bone marrow, kidneys and liver. Exposure at high levels could cause unconsciousness. Medical observation is indicated. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the blood and bone marrow. This may result in anaemia and lesions of blood cells. May cause toxicity to human reproduction or development. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation, through the skin and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 25 ppm (80 mg/m³) | 25 | 80 | Y |
| NIOSH | TWA | 0.1 ppm (0.3 mg/m³) | 0.1 | 0.3 | Y |
| ACGIH | TWA | 0.1 ppm [2005] | 0.1 | - | Y |
| CAL/OSHA | TWA | 5 ppm (16 mg/m³) | 5 | 16 | Y |
| NIOSH | IDLH | 200 ppm | 200 | - | - |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Cons electronics mech appliances and machinery; Europe | Danish Environmental Protection Agency | Danish EPA |
| artificial_saliva; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA | State of Minnesota |
| children; WA Children's Safe Product Act (4/2020) | State of Washington Department of Ecology | State of Washington |
| Canada; pharmaceutical | DrugBank | DrugBank |
| children | Vermont Department of Health | State of Vermont |
| children | Oregon Health Authority | State of Oregon |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| Pesticides | California Department of Pesticide Regulation | State of California |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
| banned; Europe; Personal care | European Commission | CosIng |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v48je14 |
| =5 | mg/kg bw/day | ADI | - | - | INCHEM_WHO_jecfa_jecmono_v48je14 |
| =0.73 | mg/m3 | BMCL (10 HEC) | inhalation | Rabbit | ToxValDB_PPRTV_(CPHEA) |
| =1.64 | mg/kg bw/day | BMDL (05) | oral | Monkey | ToxValDB_PPRTV_(CPHEA) |
| =25 | mg/kg bw/day | BMDL (10) | oral | Rat | ToxValDB_ECHA_IUCLID |
| SQEoral=63 | ug/day | California Proposition 65 MADL | - | - | California Proposition 65 |
| SQEoral=63 | ug/day | California Proposition 65 MADL | - | - | California Proposition 65 |
| SQEoral=63 | ug/day | California Proposition 65 MADL | - | - | California Proposition 65 |
| SQEoral=63 | ug/day | California Proposition 65 MADL | - | - | California Proposition 65 |
| SQEdevelopmental, male | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEdevelopmental, male | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEdevelopmental, male | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| SQEdevelopmental, male | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| =0.31 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| EK1L6XWI56 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EK1L6XWI56 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EK1L6XWI56 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| EK1L6XWI56 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4.6655 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| range12 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| >15.8 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =2257 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =2370 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =2460 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =3400 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =3930 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =71 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =71 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =135 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ToxRefDB |
| =135 | mg/kg bw/day | LEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =295 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =295 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =492 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB_ToxRefDB |
| =492 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| ~950 | mg/m3 | LEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =56021.1 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| =311.229 | mg/m3 | LOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =933.686 | mg/m3 | LOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =25 | mg/kg bw/day | LOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =100 | ppm | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =114 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =165 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ToxRefDB |
| =165 | mg/kg bw/day | LOAEL | oral | rat (fischer; Fischer 344) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =311 | mg/m3 | LOAEL | inhalation | Rabbit | ToxValDB_IRIS |
| =529 | mg/kg bw/day | LOAEL | oral | Mouse | ToxValDB_ToxRefDB |
| =529 | mg/kg bw/day | LOAEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =902 | mg/kg bw/day | LOAEL | oral | Mouse | ToxValDB_ToxRefDB |
| =902 | mg/kg bw/day | LOAEL | oral | mouse (b6c3f1; B6C3F1) | ToxRefDB_ToxRefDB_v3_pod.csv |
| =933.686 | mg/m3 | LOAEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | LOAEL | dermal | Rat | ToxValDB_ECHA_IUCLID |
Showing 50 of 100 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-methoxyethanol | 203-713-7 | ECHA overview → |
TRI hazard and reporting flags for the matched chemical.
| Chemical | Category | Flags |
|---|---|---|
| 2-Methoxyethanol | - | - |
| 2-Methoxyethanol (EGME) | N230 - Certain Glycol Ethers | - |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
2-Methoxyethanol (CAS 109-86-4) is classified under EU CLP Annex VI as Flam. Liq. 3; Repr. 1B; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 * with signal word Danger. Hazard statements: H226; H360FD; H332; H312; H302. Source: EU CLP Annex VI (ECHA).
2-Methoxyethanol has 100 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.
2-Methoxyethanol appears on 12 regulatory/inventory lists including Cons electronics mech appliances and machinery; Europe, artificial_saliva; detected; emissions; Europe; Toys and children's products, detected; drinking_water; MN Chemical Screening, and 9 more. Source: EPA CPDat.
Yes, 2-Methoxyethanol is listed under California Proposition 65 for developmental, male. Source: California OEHHA Proposition 65.
Yes, 2-Methoxyethanol is listed on the ECHA REACH Candidate List as a Substance of Very High Concern. Reason: Toxic for reproduction (Article 57c). Source: ECHA SVHC Candidate List.
Occupational exposure limits for 2-Methoxyethanol are set by OSHA, NIOSH, ACGIH. 5 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, 2-Methoxyethanol is also indexed as a cosmetic ingredient under the name Methoxyethanol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ECHA SVHC Candidate List, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
2-Methoxyethanol is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H360FD, H332, H312, H302).
2-Methoxyethanol also appears in cosmetics, pharmaceutical databases.