What is the GHS hazard classification for Pentanoic acid?
Pentanoic acid (CAS 109-52-4) is classified under EU CLP Annex VI as Skin Corr. 1B; Aquatic Chronic 3 with signal word Danger. Hazard statements: H314; H412. Source: EU CLP Annex VI (ECHA).
Danger
GHS05
NOAEL Data
REACH Registered
Cosmetic Ingredient
Pentanoic acid
Also known as: Valeric acid, 4-02-00-00868, BRN 0969454, EINECS 203-677-2, FEMA No. 3101 (+15 more)
CAS 109-52-4
Pentanoic acid (CAS 109-52-4) is a chemical substance with GHS signal word Danger; key hazard signal: H314; H412. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Cross-Vertical Regulatory Divergence
Pentanoic acid is classified GHS Danger (H314, H412) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
18
SOURCE
Chemical inventory jurisdictions
Regulatory lists
6
SOURCE
EU CLP Annex VI
GHS signal
Danger
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Pentanoic acid
CAS Number
109-52-4
DTXSID
DTXSID7021655
Molecular Formula
C5H10O2
InChI Key
NQPDZGIKBAWPEJ-UHFFFAOYSA-N
Monoisotopic Mass
102.06808
Synonyms
Valeric acid4-02-00-00868BRN 0969454EINECS 203-677-2FEMA No. 3101Valerianic acidVALERIC ACID, N-UNII-GZK92PJM7B1-Butanecarboxylate1-Pentanoate1-Pentanoic acidButanecarboxylate
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Skin Corr. 1B; Aquatic Chronic 3 | H314; H412 | GHS05 | Danger |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
WHO/JECFA
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| artificial_saliva; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 18 of 18 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| GZK92PJM7B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GZK92PJM7B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GZK92PJM7B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GZK92PJM7B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1055 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =1720 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =1844 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =4600 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =66835.8 | mg/m3 | LEL | inhalation | Human | ToxValDB DOE Protective Action Criteria |
| =750 | mg/kg bw/day | LOAEL | oral | Rat | ECHA |
| =0.1 | mM | LOEL | environmental | European Rabbit | ToxValDB ECOTOX |
| =25 | mg | LOEL | dermal | Mouse | ToxValDB ECOTOX |
| - | unitless | Model Score | - | - | NTP ICE endocrine |
| 50 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| 75 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 750 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| =50 | mg/kg bw/day | NOEL | oral | Rat | ECHA |
Showing 18 of 18 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Valeric acid | 203-677-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
VALERIC ACID
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Pentanoic acid?
Pentanoic acid has 18 NOAEL studies in the database. The lowest reported value is GZK92PJM7B UNII. Source: openFDA substances.
What regulatory lists include Pentanoic acid?
Pentanoic acid appears on 6 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Canada; pharmaceutical, artificial_saliva; detected; emissions; Europe; Toys and children's products, and 3 more. Source: EPA CPDat.
Is Pentanoic acid used in cosmetics?
Yes, Pentanoic acid is also indexed as a cosmetic ingredient under the name Valeric Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Pentanoic acid come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Pentanoic acid have different safety status in cosmetics vs industrial chemicals?
Pentanoic acid is classified GHS Danger (H314, H412) in the chemicals database but is allowed in EU cosmetics.
Is Pentanoic acid used outside industrial chemicals?
Pentanoic acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.