What is the GHS hazard classification for Diisobutyl ketone?
Diisobutyl ketone (CAS 108-83-8) is classified under EU CLP Annex VI as Flam. Liq. 3; STOT SE 3 with signal word Warning. Hazard statements: H226; H335. Source: EU CLP Annex VI (ECHA).
Warning
GHS02GHS07
NOAEL Data
REACH Registered
Cosmetic Ingredient
Diisobutyl ketone
Also known as: Diisobutylketone (4-Heptanone, 2,6-dimethyl-), 4-01-00-03360, BRN 1743163, Caswell No. 355B, sec-Diisopropyl acetone (+11 more)
CAS 108-83-8
Diisobutyl ketone (CAS 108-83-8) is a chemical substance with GHS signal word Warning; key hazard signal: H226; H335. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
SOURCE
noael studies public
NOAEL studies
14
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
22 fields
Name
Diisobutyl ketone
CAS Number
108-83-8
DTXSID
DTXSID4025080
Molecular Formula
C9H18O
InChI Key
PTTPXKJBFFKCEK-UHFFFAOYSA-N
Monoisotopic Mass
142.135765
Synonyms
Diisobutylketone (4-Heptanone, 2,6-dimethyl-)4-01-00-03360BRN 1743163Caswell No. 355Bsec-Diisopropyl acetonesym-Diisopropylacetone2,6-DimethylheptanoneEINECS 203-620-1FEMA No. 3537Valerone2,6-Dimethyl-heptan-4-on2,6-Dimetil-eptan-4-one
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Flam. Liq. 3; STOT SE 3 | H226; H335 | GHS02; GHS07 | Warning |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. Exposure to high concentrations could cause lowering of consciousness. |
| Long-term Effects | Repeated or prolonged contact with skin may cause dermatitis. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour and by ingestion. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
5 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 50 ppm (290 mg/m³) | 50 | 290 | N |
| NIOSH | TWA | 25 ppm (150 mg/m³) | 25 | 150 | N |
| ACGIH | TWA | 25 ppm [1979] | 25 | - | N |
| CAL/OSHA | TWA | 25 ppm (150 mg/m³) | 25 | 150 | N |
| NIOSH | IDLH | 500 ppm | 500 | - | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
20 records
FragranceSolventFlavouring and nutrientBinderFilm former
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Arts and crafts/Office supplies - general arts and crafts supplies; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Specialty occupational products | Danish Environmental Protection Agency | Danish EPA |
| Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 14 of 14 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =53 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 0.7 | unitless | Draize rabbit irritation score | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 4 | unitless | EPA Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| V52W30H1BU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| V52W30H1BU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| V52W30H1BU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| V52W30H1BU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >14.5 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =46541.6 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| >180 | s | Lag time | Ocular | - | NTP_ICE_eye_irritation |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 714 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1429 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| - | % | Plateau level | Ocular | - | NTP_ICE_eye_irritation |
Showing 14 of 14 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,6-dimethylheptan-4-one | 203-620-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3182186
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What is the NOAEL for Diisobutyl ketone?
Diisobutyl ketone has 14 NOAEL studies in the database. The lowest reported value is 0.7 unitless via Ocular in Rabbit. Source: NTP_ICE_eye_irritation.
What regulatory lists include Diisobutyl ketone?
Diisobutyl ketone appears on 7 regulatory/inventory lists including IFRA Transparency, Europe, inert_ingredient; non_food_use; Pesticides, and 4 more. Source: EPA CPDat.
What are the occupational exposure limits for Diisobutyl ketone?
Occupational exposure limits for Diisobutyl ketone are set by OSHA, NIOSH, ACGIH. 5 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Diisobutyl ketone used in cosmetics?
Yes, Diisobutyl ketone is also indexed as a cosmetic ingredient under the name 2,6-Dimethyl-4-heptanone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Diisobutyl ketone come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Diisobutyl ketone used outside industrial chemicals?
Diisobutyl ketone also appears in cosmetics, pharmaceutical databases.