Warning GHS02GHS07GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

1,3,5-Trimethylbenzene

Also known as: EINECS 203-604-4, Fleet-X, UNII-887L18KQ6X, s-trimethylbenzene

CAS 108-67-8

1,3,5-Trimethylbenzene (CAS 108-67-8) is a chemical substance with GHS signal word Warning; key hazard signal: H226; H335; H411. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Mesitylene →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 10 fields

Name

1,3,5-Trimethylbenzene

CAS Number

108-67-8

DTXSID

DTXSID6026797

Molecular Formula

C9H12

InChI Key

AUHZEENZYGFFBQ-UHFFFAOYSA-N

Monoisotopic Mass

120.0939

Synonyms

EINECS 203-604-4Fleet-XUNII-887L18KQ6Xs-trimethylbenzene

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications

Hazard Class	H-Statements	Pictograms	Signal
Flam. Liq. 3; STOT SE 3; Aquatic Chronic 2	H226; H335; H411	GHS02; GHS07; GHS09	Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	The substance is irritating to the eyes, skin and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. The substance may cause effects on the central nervous system.
Long-term Effects	The substance defats the skin, which may cause dryness or cracking. Repeated or prolonged inhalation may cause effects on the lungs. This may result in chronic bronchitis. The substance may have effects on the central nervous system and blood. See Notes.
Routes of Exposure	The substance can be absorbed into the body by inhalation.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 7 records

SolventDegradant/impurityFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 6 records

List	Keyword	Source
detected; ground_water; MN Chemical Screening	Minnesota Pollution Control Agency	State of Minnesota
detected; drinking_water; MN Chemical Screening	USGS	State of Minnesota
detected; drinking_water; MN Chemical Screening	USGS	State of Minnesota
IFRA Transparency	IFRA	IFRA
air; detected; emissions; Europe; Toys and children's products	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - general arts and crafts supplies; Europe	Danish Environmental Protection Agency	Danish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 38 of 38 studies

Value	Unit	Endpoint	Route	Species	Source
=18.15	mg/m3	BMCL (1SD HEC)	inhalation	Rat	ToxValDB_IRIS
=18.15	mg/m^3	BMCL 1SD (HEC)	inhalation	-	EPA_IRIS_iris_rfc_systems.csv
=3.5	mg/kg bw/day	BMDL (1SD HED)	oral	Rat	ToxValDB_IRIS
=3.5	mg/kg/day	BMDL 1SD (HED)	oral	-	EPA_IRIS_iris_rfd_systems.csv
=100	mg/m3	DNEL local	inhalation	Human	ToxValDB_GESTIS_DNEL
887L18KQ6X	UNII	FDA UNII substance identifier	-	-	openFDA substances
887L18KQ6X	UNII	FDA UNII substance identifier	-	-	openFDA substances
887L18KQ6X	UNII	FDA UNII substance identifier	-	-	openFDA substances
887L18KQ6X	UNII	FDA UNII substance identifier	-	-	openFDA substances
24	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=2551.39	mg/m3	LEL	inhalation	Mouse	ToxValDB_ECHA_IUCLID
300	ppm	LOEL	Inhalation	Rat	NTP_ICE_dart
300	ppm	LOEL	Inhalation	Rat	NTP_ICE_dart
600	ppm	LOEL	Inhalation	Rat	NTP_ICE_dart
-	unitless	Model Score	-	-	NTP_ICE_endocrine
=491.598	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=1228.99	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=5900	mg/m3	NOAEC	inhalation	Rat	ToxValDB_ECHA_IUCLID
=143	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_Cal_OEHHA
=600	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=0.007	mg/m3	RfC	inhalation	Human	ToxValDB_Alaska_DEC
=0.007	mg/m3	RfC	inhalation	Human	ToxValDB_Alaska_DEC
=0.06	mg/m3	RfC	inhalation	Human	ToxValDB_IRIS
=0.06	mg/m^3	RfC	inhalation	-	EPA_IRIS_iris_rfc_systems.csv
=0.2	mg/m3	RfC	inhalation	Human	ToxValDB_IRIS
=0.2	mg/m^3	RfC	inhalation	-	EPA_IRIS_iris_substances.csv
=0.2	mg/m^3	RfC	inhalation	-	EPA_IRIS_iris_rfc_systems.csv
=0.00171	mg/kg bw/day	RfD	inhalation	Human	ToxValDB_Alaska_DEC
=0.00171	mg/kg bw/day	RfD	inhalation	Human	ToxValDB_Alaska_DEC
=0.01	mg/kg bw/day	RfD	oral	Human	ToxValDB_IRIS
=0.01	mg/kg/day	RfD	oral	-	EPA_IRIS_iris_rfd_systems.csv
=0.04	mg/kg bw/day	RfD	dermal	Human	ToxValDB_Alaska_DEC
=0.04	mg/kg bw/day	RfD	dermal	Human	ToxValDB_Alaska_DEC
=0.04	mg/kg bw/day	RfD	oral	Human	ToxValDB_IRIS
=0.04	mg/kg/day	RfD	oral	-	EPA_IRIS_iris_rfd_systems.csv
=0.04	mg/kg/day	RfD	oral	-	EPA_IRIS_iris_substances.csv
=0.05	mg/kg bw/day	RfD	oral	Human	ToxValDB_Alaska_DEC
=0.05	mg/kg bw/day	RfD	oral	Human	ToxValDB_Alaska_DEC

Showing 38 of 38 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Mesitylene	203-604-4	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1797281

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for 1,3,5-Trimethylbenzene?

1,3,5-Trimethylbenzene (CAS 108-67-8) is classified under EU CLP Annex VI as Flam. Liq. 3; STOT SE 3; Aquatic Chronic 2 with signal word Warning. Hazard statements: H226; H335; H411. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 1,3,5-Trimethylbenzene?

1,3,5-Trimethylbenzene has 38 NOAEL studies in the database. The lowest reported value is 3.5 mg/kg bw/day via oral in Rat. Source: ToxValDB_IRIS.

What regulatory lists include 1,3,5-Trimethylbenzene?

1,3,5-Trimethylbenzene appears on 5 regulatory/inventory lists including detected; ground_water; MN Chemical Screening, detected; drinking_water; MN Chemical Screening, IFRA Transparency, and 2 more. Source: EPA CPDat.

Is 1,3,5-Trimethylbenzene used in cosmetics?

Yes, 1,3,5-Trimethylbenzene is also indexed as a cosmetic ingredient under the name Mesitylene. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1,3,5-Trimethylbenzene come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is 1,3,5-Trimethylbenzene used outside industrial chemicals?

1,3,5-Trimethylbenzene also appears in cosmetics, pharmaceutical databases.