What is the NOAEL for 2,6-Dimethylpyrazine?
2,6-Dimethylpyrazine has 5 NOAEL studies in the database. The lowest reported value is N77Q72C9I3 UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
2,6-Dimethylpyrazine
Also known as: 2,6-Dimethyl-1,4-diazine, 2,6-Dimethylparadiazine, 2,6-Dimethylpiazine, EINECS 203-589-4, FEMA No. 3273 (+3 more)
CAS 108-50-9
2,6-Dimethylpyrazine (CAS 108-50-9) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
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NOAEL studies
NOAEL studies
5
SOURCE
Chemical inventory jurisdictions
Regulatory lists
3
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EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
14 fields
Name
2,6-Dimethylpyrazine
CAS Number
108-50-9
DTXSID
DTXSID5047619
Molecular Formula
C6H8N2
InChI Key
HJFZAYHYIWGLNL-UHFFFAOYSA-N
Monoisotopic Mass
108.068748
Synonyms
2,6-Dimethyl-1,4-diazine2,6-Dimethylparadiazine2,6-DimethylpiazineEINECS 203-589-4FEMA No. 3273UNII-N77Q72C9I32,6-Dimethyl-PyrazineFEMA 3273
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
4 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| N77Q72C9I3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N77Q72C9I3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N77Q72C9I3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N77Q72C9I3 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =880 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
Showing 5 of 5 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
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EFSA
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
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Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2,6-Dimethylpyrazine?
2,6-Dimethylpyrazine appears on 3 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is 2,6-Dimethylpyrazine used in cosmetics?
Yes, 2,6-Dimethylpyrazine is also indexed as a cosmetic ingredient under the name 2,6-Dimethylpyrazine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2,6-Dimethylpyrazine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 2,6-Dimethylpyrazine used outside industrial chemicals?
2,6-Dimethylpyrazine also appears in cosmetics, food safety, cannabis databases.