Also known as: 1,3-Benzenediol, 4-06-00-05658, Benzene, m-dihydroxy-, Benzene, 1,3-dihydroxy-, BRN 0906905 (+15 more)
CAS 108-46-3
Resorcinol (CAS 108-46-3) is a chemical substance with GHS signal word Danger; key hazard signal: H302; H370 (nervous system); H315; H319; H317; H400. Key regulatory status: REACH registered, 28 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, IARC, ECHA REACH, ILO ICSC, OSHA.
Resorcinol is classified GHS Danger (H302, H370, H315, H319, H317, H400) in the chemicals database but is restricted in EU cosmetics at max 1.25% in oxidative hair dye formulations.
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1998 | 15, Sup 7, 71 |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4; STOT SE 1; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1B; Aquatic Acute 1 | H302; H370 (nervous system); H315; H319; H317; H400 | GHS07; GHS08; GHS09 | Danger |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization in rare cases. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. |
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| NIOSH | TWA | 10 ppm (45 mg/m³) | 10 | 45 | N |
| NIOSH | STEL | 20 ppm (90 mg/m³) | 20 | 90 | N |
| ACGIH | TWA | 10 ppm [1992] | 10 | - | N |
| ACGIH | STEL | 20 ppm [1992] | 20 | - | N |
| CAL/OSHA | TWA | 10 ppm (45 mg/m³) | 10 | 45 | N |
| CAL/OSHA | STEL | 20 ppm (90 mg/m³) | 20 | 90 | N |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care; restricted | European Commission | CosIng |
| Europe | European Commission | Fl@vis |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring - hair color - permanent | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring - hair color - permanent | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring - hair color - professional | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring - hair color - professional | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring - hair color - professional | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| - | Regulatory Toxicology and Pharmacology | Published Articles |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| - | Danish Environmental Protection Agency | Danish EPA |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| - | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 2 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 80 | mg/kg bw/day | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 80 | - | - | oral | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 101 | mg/kg bw/d | - | - | human | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 101 | mg/kg/d | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 101 | mg/kg bw/d | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 101 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 112 | mg/kg bw | - | oral | mouse | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 112 | mg/kg bw | - | oral | mouse | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 130 | mg/kg/day | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 130 | mg/kg bw/d | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 130 | mg/kg bw/d | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 173 | mg/kg/d | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 173 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 173 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 173 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 177 | mg/kg/d | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 177 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 177 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 177 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 177 | mg/kg/d | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 177 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 177 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 177 | - | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| ~186 | mg/kg bw/day | - | oral | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| ~186 | mg/kg bw/day | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| ~233 | mg/kg bw/day | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| ~233 | mg/kg bw/day | - | - | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 304 | mg/kg bw/d | - | oral | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 304 | mg/kg bw/d | - | oral | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 520 | - | - | oral | - | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 1992 | - | - | - | rat | UnifiedCodex:SCCS_SHADOW:beta.noael_studies |
| 32.084017601991 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 28.6225831546908 | uM | ACC | - | - | NTP_ICE_endocrine |
| =0.12 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| =0.12 | mg/kg bw/day | ADI | - | Consumers | EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx |
| 201 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 201.5 | ug/mL | CD54, EC200 | Dermal | - | NTP_ICE_skin_sensitization |
| 4.75 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 29.603 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 172.97 | ug/mL | CV70 | Dermal | - | NTP_ICE_skin_sensitization |
| 613.4 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 14.48 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =132.8 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =5.6 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| -1 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| 1.6 | % | Depletion Cys | Dermal | - | NTP_ICE_skin_sensitization |
| -0.8 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
| 13.1 | % | Depletion Lys | Dermal | - | NTP_ICE_skin_sensitization |
Showing 50 of 100 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | resorcinol; 1,3-benzenediol | 203-585-2 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
EU Scientific Committee opinions tied to the matched substance.
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1619/20 | 30-31 March 2021 | safe with restrictions | 1.25% hair/eyelashes; 0.5% lotions/shampoos | moderate skin sensitiser; potential endocrine disrupting properties |
| SCCS/1390/10 | 23 March 2010 | safe with restrictions | 1.25% | sensitising potential; use with caution in persons with thyroid conditions |
| SCCP/1117/07 | 15 April 2008 | safe with restrictions | 1.25% | sensitising potential; thyroid effects at high doses |
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
Same-CAS food additive, ADI, and GRAS records where available.
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Same-CAS cannabis compliance and lab records where available.
1 cannabis record found in efsa substances.
View full cannabis profile →Resorcinol (CAS 108-46-3) is classified under EU CLP Annex VI as Acute Tox. 4; STOT SE 1; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1B; Aquatic Acute 1 with signal word Danger. Hazard statements: H302; H370 (nervous system); H315; H319; H317; H400. Source: EU CLP Annex VI (ECHA).
Resorcinol has 100 NOAEL studies in the database. The lowest reported value is -1 % via Dermal. Source: NTP_ICE_skin_sensitization.
Resorcinol appears on 13 regulatory/inventory lists including Europe; Personal care; restricted, Europe, inert_ingredient; non_food_use; Pesticides, and 10 more. Source: EPA CPDat.
Resorcinol is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Occupational exposure limits for Resorcinol are set by NIOSH, ACGIH, CAL/OSHA. 6 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Yes, Resorcinol is also indexed as a cosmetic ingredient under the name Resorcinol Cosmetic. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Resorcinol is classified GHS Danger (H302, H370, H315, H319, H317, H400) in the chemicals database but is restricted in EU cosmetics at max 1.25% in oxidative hair dye formulations.
Resorcinol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.