Danger GHS08GHS06GHS09 NOAEL Data IARC Group 3 REACH Registered Cosmetic Ingredient

1,3-Benzenediamine

Also known as: m-Phenylenediamine, 4-13-00-00079, meta-Aminoaniline, Benzene, 1,3-diamino-, meta-Benzenediamine (+9 more)

CAS 108-45-2

1,3-Benzenediamine (CAS 108-45-2) is a chemical substance with GHS signal word Danger; key hazard signal: H341; H331; H311; H301; H319; H317; H400; H410. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for m-Phenylenediamine →

SOURCE noael studies public
NOAEL studies
59
SOURCE chemical inventory jurisdictions
Regulatory lists
6
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 20 fields
Name
1,3-Benzenediamine
CAS Number
108-45-2
DTXSID
DTXSID4021137
Molecular Formula
C6H8N2
InChI Key
WZCQRUWWHSTZEM-UHFFFAOYSA-N
Monoisotopic Mass
108.068748
Synonyms
m-Phenylenediamine4-13-00-00079meta-AminoanilineBenzene, 1,3-diamino-meta-BenzenediamineBRN 0471357CI Developer 11Developer 11meta-DiaminobenzeneEINECS 203-584-7m-FenylendiaminUNII-OE624J2447

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records
GroupMeaningEvaluatedVolume
Group 3Not classifiable198716, Sup 7

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Muta. 2; Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; Eye Irrit. 2; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1H341; H331; H311; H301; H319; H317; H400; H410GHS08; GHS06; GHS09Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
Short-term EffectsThe substance is irritating to the eyes and skin. The substance may cause effects on the kidneys and blood. This may result in renal failure and the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated.
Long-term EffectsRepeated or prolonged contact may cause skin sensitization. The substance may have effects on the kidneys. This may result in renal failure.
Routes of ExposureThe substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 1 records
AgencyMetricValueppmmg/m3Skin
ACGIHTWA0.1 mg/m³ [1988]-0.1N

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 3 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 6 records
ListKeywordSource
CEDIFDAUnited States Food and Drug Administration (FDA)
Indirect additives food contact (10/2018)FDAUnited States Food and Drug Administration (FDA)
Europe; Food contact items; Toys and children's productsDanish EPADanish EPA
banned; Europe; Personal careEuropean CommissionCosIng
drinking_water; Europe; manufacturing; plastic_additiveBelgaquaCPCat
banned; Europe; Personal careEuropean CommissionCosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 59 studies
ValueUnitEndpointRouteSpeciesSource
-uL/min/10^6 cellsClint-HumanNTP_ICE_adme_parameters
=0.24mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
0.49%EC3DermalMouseNTP_ICE_skin_sensitization
0.49%EC3DermalMouseNTP_ICE_skin_sensitization
0.49%EC3DermalMouseNTP_ICE_skin_sensitization
0.49%EC3DermalMouseNTP_ICE_skin_sensitization
OE624J2447UNIIFDA UNII substance identifier--openFDA substances
OE624J2447UNIIFDA UNII substance identifier--openFDA substances
OE624J2447UNIIFDA UNII substance identifier--openFDA substances
OE624J2447UNIIFDA UNII substance identifier--openFDA substances
1unitlessGHS ClassificationOcularRabbitNTP_ICE_eye_irritation
3IARC groupIARC carcinogenicity classification--IARC Monographs
3IARC groupIARC carcinogenicity classification--IARC Monographs
3IARC groupIARC carcinogenicity classification--IARC Monographs
3unitlessIARC group--NTP_ICE_cancer
0.35%/secIntensityOcular-NTP_ICE_eye_irritation
=280mg/kg bwLD50oralRatNTP_ICE_acute_oral
=650mg/kg bwLD50oralRatNTP_ICE_acute_oral
=25mg/kg bw/dayLELoralCatToxValDB_ECHA_IUCLID
>100mg/kg bw/dayLELoralRatToxValDB_ECHA_IUCLID
>=200mg/kg bw/dayLELinjectionCatToxValDB_ECHA_IUCLID
=370mg/kg bw/dayLELinjectionRabbitToxValDB_ECHA_IUCLID
=400mg/kg bw/dayLELinjectionMouseToxValDB_ECHA_IUCLID
<=435mg/kg bw/dayLELinjectionCatToxValDB_ECHA_IUCLID
<=440mg/kg bw/dayLELinjectionRabbitToxValDB_ECHA_IUCLID
=450mg/kg bw/dayLELoralRatToxValDB_ECHA_IUCLID
=460mg/kg bw/dayLELinjectionRatToxValDB_ECHA_IUCLID
=720mg/m3LELinhalationRatToxValDB_ECHA_IUCLID
=1000mg/kg bw/dayLELoralRatToxValDB_ECHA_IUCLID
=18mg/kg bw/dayLOAELoralRatToxValDB_IRIS
10sLag timeOcular-NTP_ICE_eye_irritation
-unitlessModel Score--NTP_ICE_endocrine
=5mg/kgNOAEL-ratCIR_vision_codex
=5mg/kgNOAEL-ratCIR_vision_codex
=5mg/kgNOAEL-ratCIR_vision_codex
=5mg/kgNOAEL-ratCIR_vision_codex
=6mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=6mg/kgNOAELdermalratCIR_vision_codex
=6mg/kgNOAELdermalratCIR_vision_codex
=6mg/kgNOAELdermalratCIR_vision_codex
=6mg/kgNOAELdermalratCIR_vision_codex
=20mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=30mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=38.2mg/kg bw/dayNOAELoralMouseToxValDB_ECHA_IUCLID
=41.8mg/kg bw/dayNOAELoralMouseToxValDB_ECHA_IUCLID
=134mg/kg/dayNOAELoralratCIR_vision_codex
=134mg/kg/dayNOAELoralratCIR_vision_codex
=134mg/kg/dayNOAELoralratCIR_vision_codex
=134mg/kg/dayNOAELoralratCIR_vision_codex
>=300mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID

Showing 50 of 59 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registeredm-phenylenediamine203-584-7ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records
ChemicalCategoryFlags
1,3-Phenylenediamine--

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Colorant
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1595914
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for 1,3-Benzenediamine?

1,3-Benzenediamine (CAS 108-45-2) is classified under EU CLP Annex VI as Muta. 2; Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; Eye Irrit. 2; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H341; H331; H311; H301; H319; H317; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 1,3-Benzenediamine?

1,3-Benzenediamine has 59 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.

What regulatory lists include 1,3-Benzenediamine?

1,3-Benzenediamine appears on 5 regulatory/inventory lists including CEDI, Indirect additives food contact (10/2018), Europe; Food contact items; Toys and children's products, and 2 more. Source: EPA CPDat.

Is 1,3-Benzenediamine a carcinogen according to IARC?

1,3-Benzenediamine is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1987). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

What are the occupational exposure limits for 1,3-Benzenediamine?

Occupational exposure limits for 1,3-Benzenediamine are set by ACGIH. 1 limit value from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is 1,3-Benzenediamine used in cosmetics?

Yes, 1,3-Benzenediamine is also indexed as a cosmetic ingredient under the name m-Phenylenediamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1,3-Benzenediamine come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 1,3-Benzenediamine have different safety status in cosmetics vs industrial chemicals?

1,3-Benzenediamine is prohibited in EU cosmetics but has active industrial GHS classifications (H341, H331, H311, H301, H319, H317, H400, H410).

Is 1,3-Benzenediamine used outside industrial chemicals?

1,3-Benzenediamine also appears in cosmetics, pharmaceutical databases.