What is the NOAEL for Isopropyl acetate?
Isopropyl acetate has 21 NOAEL studies in the database. The lowest reported value is 39.6993783454885 uM. Source: NTP_ICE_endocrine.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Isopropyl acetate
Also known as: Acetic acid, 1-methylethyl ester, 4-02-00-00141, BRN 1740761, EINECS 203-561-1, FEMA No. 2926 (+6 more)
CAS 108-21-4
Isopropyl acetate (CAS 108-21-4) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
Cross-Vertical Regulatory Divergence
Isopropyl acetate is classified GHS Danger (H225, H319, H336, H303, H305, H315, H320, H335) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
21
SOURCE
chemical inventory jurisdictions
Regulatory lists
7
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
Isopropyl acetate
CAS Number
108-21-4
DTXSID
DTXSID2025478
Molecular Formula
C5H10O2
InChI Key
JMMWKPVZQRWMSS-UHFFFAOYSA-N
Monoisotopic Mass
102.06808
Synonyms
Acetic acid, 1-methylethyl ester4-02-00-00141BRN 1740761EINECS 203-561-1FEMA No. 2926ParacetatIsopropyl (acetate d')IsopropylacetaatIsopropyle (acetate d')Isopropylester kyseliny octoveUNII-1Y67AFK870
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Highly flammable liquid and vapour May cause drowsiness or dizziness Harmful to aquatic life |
| Short-term Effects | The substance may be irritating to the eyes, skin and respiratory tract. Exposure far above the OEL could cause lowering of consciousness. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour and by ingestion. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
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OSHA / NIOSH / ACGIH occupational exposure limits
6 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 250 ppm (950 mg/m³) | 250 | 950 | N |
| ACGIH | TWA | 100 ppm [2017] | 100 | - | N |
| ACGIH | STEL | 150 ppm [2017] | 150 | - | N |
| CAL/OSHA | TWA | 250 ppm (950 mg/m³) | 250 | 950 | N |
| CAL/OSHA | STEL | 310 ppm (1185 mg/m³) | 310 | 1185 | N |
| NIOSH | IDLH | 1800 ppm | 1800 | - | - |
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
10 records
SolventFragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
7 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 21 of 21 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 39.6993783454885 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 42.1445699661997 | uM | ACC | - | - | NTP_ICE_endocrine |
| =227 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =275 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 1Y67AFK870 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1Y67AFK870 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1Y67AFK870 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1Y67AFK870 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 50.6 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =3000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =6750 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =3064 | mg/kg bw/day | LEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =75190.3 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| =1462.03 | mg/m3 | LOEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0152 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =2088.62 | mg/m3 | NOAEC | inhalation | Mouse | ToxValDB_ECHA_IUCLID |
| =2113.68 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| ~14662.1 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =596 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =700 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 21 of 21 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Isopropyl acetate | 203-561-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1608674
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Frequently Asked Questions
What regulatory lists include Isopropyl acetate?
Isopropyl acetate appears on 6 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, consumer_product; Europe, consumer_product; detected; Europe, and 3 more. Source: EPA CPDat.
What are the occupational exposure limits for Isopropyl acetate?
Occupational exposure limits for Isopropyl acetate are set by OSHA, ACGIH, CAL/OSHA. 6 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Isopropyl acetate used in cosmetics?
Yes, Isopropyl acetate is also indexed as a cosmetic ingredient under the name Isopropyl Acetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Isopropyl acetate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Does Isopropyl acetate have different safety status in cosmetics vs industrial chemicals?
Isopropyl acetate is classified GHS Danger (H225, H319, H336, H303, H305, H315, H320, H335) in the chemicals database but is allowed in EU cosmetics.
Is Isopropyl acetate used outside industrial chemicals?
Isopropyl acetate also appears in cosmetics, pharmaceutical, food safety databases.