Danger GHS02GHS08GHS07 NOAEL Data IARC Group 2B Prop 65 REACH Registered Cosmetic Ingredient

Vinyl acetate

Also known as: Acetic acid ethenyl ester, Acetic acid, ethylene ether, EINECS 203-545-4, Ethanoic acid, ethenyl ester, Vinyl acetate H.Q. (+12 more)

CAS 108-05-4

Vinyl acetate (CAS 108-05-4) is a chemical substance with GHS signal word Danger; key hazard signal: H225; H351; H332; H335. Key regulatory status: California Proposition 65, REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, CA Prop 65, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for Vinyl Acetate →

SOURCE noael studies public
NOAEL studies
77
SOURCE chemical inventory jurisdictions
Regulatory lists
8
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 23 fields
Name
Vinyl acetate
CAS Number
108-05-4
DTXSID
DTXSID3021431
Molecular Formula
C4H6O2
InChI Key
XTXRWKRVRITETP-UHFFFAOYSA-N
Monoisotopic Mass
86.036779
Synonyms
Acetic acid ethenyl esterAcetic acid, ethylene etherEINECS 203-545-4Ethanoic acid, ethenyl esterVinyl acetate H.Q.VinylacetateZeset TOctan winyluVinylacetaatVinylester kyseliny octoveUNII-L9MK238N77Essigsaeurevinylester

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records
GroupMeaningEvaluatedVolume
Group 2BPossibly carcinogenic1995Sup 7, 63

California Proposition 65

California OEHHA listing status and toxicity category.

SOURCE California OEHHA Proposition 65 List 1 records
ChemicalToxicity TypeCancerDevelopmentalListed
-cancerYesNo-

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Flam. Liq. 2; Carc. 2; Acute Tox. 4; STOT SE 3H225; H351; H332; H335GHS02; GHS08; GHS07Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
GHS Signal WordDANGER
GHS Hazard StatementsHighly flammable liquid and vapour Toxic if inhaled May be harmful if swallowed or in contact with skin Suspected of causing cancer May cause respiratory irritation Harmful to aquatic life
Short-term EffectsThe substance is irritating to the respiratory tract. The substance is mildly irritating to the eyes and skin.
Long-term EffectsRepeated or prolonged contact with skin may cause dryness and cracking. This substance is possibly carcinogenic to humans.
Routes of ExposureThe substance can be absorbed into the body by inhalation, through the skin and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 8 records
AgencyMetricValueppmmg/m3Skin
NIOSHCEILING4 ppm (15 mg/m³), [15 minutes]415N
ACGIHTWA10 ppm [1992]10-N
ACGIHSTEL15 ppm [1992]15-N
CAL/OSHATWA10 ppm (30 mg/m³)1030N
CAL/OSHASTEL15 ppm (45 mg/m³)1545N
AIHAERPG-15 ppm5--
AIHAERPG-275 ppm75--
AIHAERPG-3500 ppm500--

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 51 records
Film formerBinderDegradant/impurityAdhesion/cohesion promoterMonomersAnti-adhesive/cohesiveLubricating agentSurface modifierSolventFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 8 records
ListKeywordSource
inert_ingredient; non_food_use; PesticidesEPACPCat
drinking_water; Europe; manufacturing; plastic_additiveBelgaquaCPCat
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
Australia; Food and drug - smoking-related productsNew Zealand ESRCPCat
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
banned; Europe; Personal careEuropean CommissionCosIng
Europe; Food contact items; Toys and children's productsDanish EPADanish EPA
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; EuropeDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 77 studies
ValueUnitEndpointRouteSpeciesSource
=440mg/kg bw/dayBMDL (10)oralMouseToxValDB_EFSA
=477mg/kg bw/dayBMDL (10)oralRatToxValDB_ECHA_IUCLID
SQEcancerlisting typeCalifornia Proposition 65 listing--California Proposition 65
SQEcancerlisting typeCalifornia Proposition 65 listing--California Proposition 65
SQEcancerlisting typeCalifornia Proposition 65 listing--California Proposition 65
SQEcancerlisting typeCalifornia Proposition 65 listing--California Proposition 65
=17.6mg/m3DNEL localinhalationHumanToxValDB_GESTIS_DNEL
L9MK238N77UNIIFDA UNII substance identifier--openFDA substances
L9MK238N77UNIIFDA UNII substance identifier--openFDA substances
L9MK238N77UNIIFDA UNII substance identifier--openFDA substances
L9MK238N77UNIIFDA UNII substance identifier--openFDA substances
2BIARC groupIARC carcinogenicity classification--IARC Monographs
2BIARC groupIARC carcinogenicity classification--IARC Monographs
2BIARC groupIARC carcinogenicity classification--IARC Monographs
2unitlessIARC group--NTP_ICE_cancer
11.3941mg/LLC50Inhalation-NTP_ICE_acute_inhalation
11.4mg/LLC50Inhalation-NTP_ICE_acute_inhalation
12.9495mg/LLC50Inhalation-NTP_ICE_acute_inhalation
=250mg/kg bw/dayLELoralRabbitToxValDB_EPA_TSCA_8e
=500mg/kg bw/dayLELoralRabbitToxValDB_EPA_TSCA_8e
=14084.3mg/m3LELinhalationRatToxValDB_ECHA_IUCLID
=91548.1mg/m3LELinhalationHumanToxValDB_DOE_Protective_Action_Criteria
=70.4216mg/m3LOAELinhalationHumanToxValDB_TX_TCEQ
=704mg/m3LOAELinhalationRatToxValDB_IRIS
=3521.08mg/m3LOAELinhalationRatToxValDB_ECHA_IUCLID
=126mg/m3LOAEL (ADJ)inhalationRatToxValDB_IRIS
=19mg/m3LOAEL (HEC)inhalationRatToxValDB_IRIS
=1.05632mg/m3MRLinhalationHumanToxValDB_ATSDR_MRLs
=2.46476mg/m3MRLinhalationHumanToxValDB_ATSDR_MRLs
=3.52108mg/m3MRLinhalationHumanToxValDB_ATSDR_MRLs
=176.054mg/m3NOAECinhalationRatToxValDB_ECHA_IUCLID
=528.162mg/m3NOAECinhalationRatToxValDB_ECHA_IUCLID
=704.216mg/m3NOAECinhalationRatToxValDB_ECHA_IUCLID
=29.9996mg/m3NOAELinhalationRat (Crl:CD(SD)BR Sprague-Dawley; M/F)ATSDR_toxval_ATSDR_MRLs.xlsx
=35.2108mg/m3NOAELinhalationHumanToxValDB_EU_SCOEL
=76.0554mg/m3NOAELinhalationRat (Sprague-Dawley (Crl:CD BR); M)ATSDR_toxval_ATSDR_MRLs.xlsx
=98mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
>=100mg/kg bw/dayNOAELoralRabbitToxValDB_ECHA_IUCLID
=102.463mg/m3NOAELinhalationRat (Sprague-Dawley (Crl:CD BR); M)ATSDR_toxval_ATSDR_MRLs.xlsx
=146mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=173.941mg/m3NOAELinhalationRatToxValDB_ATSDR_MRLs
=173.941mg/m3NOAELinhalationRat (Crl:CD(SD)BR Sprague-Dawley; M/F)ATSDR_toxval_ATSDR_MRLs.xlsx
=176mg/m3NOAELinhalationRatToxValDB_IRIS
=176.054mg/m3NOAELinhalationRatToxValDB_Cal_OEHHA_REL_derivations
=202mg/kg bw/dayNOAELoralMouseToxValDB_ECHA_IUCLID
=223mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=281mg/kg bw/dayNOAELoralMouseToxValDB_ECHA_IUCLID
=285mg/kg bw/dayNOAELoralMouseToxValDB_ECHA_IUCLID
=301mg/kg bw/dayNOAELoralMouseToxValDB_ECHA_IUCLID
=684mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID

Showing 50 of 77 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredVinyl acetate203-545-4ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records
ChemicalCategoryFlags
Vinyl acetate--

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1470323
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

1 food-safety record found.

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Vinyl acetate?

Vinyl acetate (CAS 108-05-4) is classified under EU CLP Annex VI as Flam. Liq. 2; Carc. 2; Acute Tox. 4; STOT SE 3 with signal word Danger. Hazard statements: H225; H351; H332; H335. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Vinyl acetate?

Vinyl acetate has 77 NOAEL studies in the database. The lowest reported value is 0.0571 mg/kg bw/day via inhalation in Human. Source: ToxValDB_Alaska_DEC.

What regulatory lists include Vinyl acetate?

Vinyl acetate appears on 8 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, drinking_water; Europe; manufacturing; plastic_additive, active_ingredient; Europe; Pesticides, and 5 more. Source: EPA CPDat.

Is Vinyl acetate a carcinogen according to IARC?

Vinyl acetate is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 1995). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is Vinyl acetate on the California Proposition 65 list?

Yes, Vinyl acetate is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.

What are the occupational exposure limits for Vinyl acetate?

Occupational exposure limits for Vinyl acetate are set by NIOSH, ACGIH, CAL/OSHA. 8 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Vinyl acetate used in cosmetics?

Yes, Vinyl acetate is also indexed as a cosmetic ingredient under the name Vinyl Acetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Vinyl acetate come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Vinyl acetate have different safety status in cosmetics vs industrial chemicals?

Vinyl acetate is classified GHS Danger (H225, H351, H332, H335) in the chemicals database but is allowed in EU cosmetics.

Is Vinyl acetate used outside industrial chemicals?

Vinyl acetate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.