Danger GHS02GHS07GHS05 NOAEL Data REACH Registered Cosmetic Ingredient

Dimethylaminoethanol

Also known as: 2-Dimethylaminoethanol (Deanol) (Dimethylaminoethanol) (Ethanol, 2-(dimethylamino)-), BRN 1209235, beta-Dimethylaminoethyl alcohol, N,N-Dimethyl-N-(beta-hydroxyethyl)amine, EINECS 203-542-8 (+13 more)

CAS 108-01-0

Dimethylaminoethanol (CAS 108-01-0) is a chemical substance with GHS signal word Danger; key hazard signal: H226; H332; H312; H302; H314. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for DMAE (Dimethylaminoethanol) →

SOURCE noael studies public
NOAEL studies
32
SOURCE chemical inventory jurisdictions
Regulatory lists
4
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 24 fields
Name
Dimethylaminoethanol
CAS Number
108-01-0
DTXSID
DTXSID2020505
Molecular Formula
C4H11NO
InChI Key
UEEJHVSXFDXPFK-UHFFFAOYSA-N
Monoisotopic Mass
89.084064
Synonyms
2-Dimethylaminoethanol (Deanol) (Dimethylaminoethanol) (Ethanol, 2-(dimethylamino)-)BRN 1209235beta-Dimethylaminoethyl alcoholN,N-Dimethyl-N-(beta-hydroxyethyl)amineEINECS 203-542-8Varesal2-DwumetyloaminoetanoluDimethylaethanolaminUNII-2N6K9DRA242-(Dimethylamino)-1-ethanolDMAEDMEA

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Flam. Liq. 3; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1BH226; H332; H312; H302; H314GHS02; GHS07; GHS05Danger

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
Short-term EffectsThe substance is severely irritating to the respiratory tract. The substance is corrosive to the eyes and skin. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. See Notes. The effects may be delayed. Medical observation is indicated.
Routes of ExposureThe substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 20 records
pH regulating agentDegradant/impurityPreservativeProcessing aids not otherwise specifiedCatalyst

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 4 records
ListKeywordSource
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; EuropeDanish Environmental Protection AgencyDanish EPA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
inert_ingredient; non_food_use; PesticidesEPACPCat
Canada; pharmaceuticalDrugBankDrugBank

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 32 of 32 studies
ValueUnitEndpointRouteSpeciesSource
=1.76mg/m3DNEL localinhalationHumanToxValDB_GESTIS_DNEL
2N6K9DRA24UNIIFDA UNII substance identifier--openFDA substances
2N6K9DRA24UNIIFDA UNII substance identifier--openFDA substances
2N6K9DRA24UNIIFDA UNII substance identifier--openFDA substances
2N6K9DRA24UNIIFDA UNII substance identifier--openFDA substances
5.9789mg/LLC50Inhalation-NTP_ICE_acute_inhalation
=1182mg/kg bwLD50oralRatNTP_ICE_acute_oral
=1203mg/kg bwLD50oralRatNTP_ICE_acute_oral
=1220mg/kg bwLD50oralRatNTP_ICE_acute_oral
=2000mg/kg bwLD50oralRatNTP_ICE_acute_oral
=2083mg/kg bwLD50oralRatNTP_ICE_acute_oral
=2140mg/kg bwLD50oralRatNTP_ICE_acute_oral
>1280ppmLELoralRatToxValDB_ECHA_IUCLID
=5000ppmLELoralRatToxValDB_EPA_TSCA_8e
=58331.9mg/m3LELinhalationHumanToxValDB_DOE_Protective_Action_Criteria
=200ppmLOAELoralRatToxValDB_ECHA_IUCLID
=600mg/kg bw/dayLOAELoralRatToxValDB_ECHA_IUCLID
-unitlessModel Score--NTP_ICE_endocrine
>7mg/kg bw/dayNOAELoralMouseToxValDB_ECHA_IUCLID
=36.4574mg/m3NOAELinhalationRatToxValDB_ECHA_IUCLID
=50mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=100mg/kg bw/dayNOAELoralRabbitToxValDB_ECHA_IUCLID
=150mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
>240mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=250mg/kg bw/dayNOAELoralRabbitToxValDB_ECHA_IUCLID
=300mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
>=364.574mg/m3NOAELinhalationRatToxValDB_ECHA_IUCLID
=1000ppmNOAELoralRatToxValDB_ECHA_IUCLID
=2500ppmNOAELoralRatToxValDB_ECHA_IUCLID
=5000ppmNOAELoralRatToxValDB_ECHA_IUCLID
=87.4979mg/m3NOECinhalationRatToxValDB_ECHA_IUCLID
=87.5mg/m3NOECinhalationRatToxValDB_ECHA_IUCLID

Showing 32 of 32 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered2-dimethylaminoethanol203-542-8ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
2.5%
Category
active
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL DIMETHYLAMINOETHANOL
ChEMBL Phase
2
Adverse Events
0
Bioactivity
5
View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

1 food-safety record found.

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for Dimethylaminoethanol?

Dimethylaminoethanol (CAS 108-01-0) is classified under EU CLP Annex VI as Flam. Liq. 3; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1B with signal word Danger. Hazard statements: H226; H332; H312; H302; H314. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Dimethylaminoethanol?

Dimethylaminoethanol has 32 NOAEL studies in the database. The lowest reported value is 1.76 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include Dimethylaminoethanol?

Dimethylaminoethanol appears on 4 regulatory/inventory lists including Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), inert_ingredient; non_food_use; Pesticides, and 1 more. Source: EPA CPDat.

Is Dimethylaminoethanol used in cosmetics?

Yes, Dimethylaminoethanol is also indexed as a cosmetic ingredient under the name DMAE (Dimethylaminoethanol). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Dimethylaminoethanol come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Dimethylaminoethanol have different safety status in cosmetics vs industrial chemicals?

Dimethylaminoethanol is classified GHS Danger (H226, H332, H312, H302, H314) in the chemicals database but is allowed in EU cosmetics at max 2.5%.

Is Dimethylaminoethanol used outside industrial chemicals?

Dimethylaminoethanol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.